Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice

William J Murphy, Scott K. Durum, Dan L. Longo

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Growth hormone (GH) has previously been implicated in T-cell development, and here we test its efficacy in promoting T-lymphocyte engraftment in mice with severe combined immune deficiency (SCID). SCID mice receiving syngeneic thymocytes and treated with recombinant human GH(rhGH) had significantly better T-cell engraftment in their lymph nodes. Human T-cell engraftment was also strongly promoted by rhGH in SCID recipients receiving human peripheral blood lymphocytes. Additionally, although mature human cells have not been thought to enter the murine thymus, human T cells were detected in the SCID thymus after rhGH treatment. Thus, rhGH can be used to optimize long-term peripheral T-cell engraftment in these human-mouse chimeras and may also be useful clinically in treating T-cell deficiencies.

Original languageEnglish (US)
Pages (from-to)4481-4485
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number10
StatePublished - 1992
Externally publishedYes

Keywords

  • AIDS animal model
  • Immune reconstitution
  • Neuroendocrine immune effects

ASJC Scopus subject areas

  • Genetics
  • General

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