TY - JOUR
T1 - Human granulocytic ehrlichiosis in Northern California
T2 - Two case descriptions with genetic analysis of the ehrlichiae
AU - Foley, Janet E
AU - Crawford-Miksza, Leta
AU - Dumler, J. Stephen
AU - Glaser, Carol
AU - Chae, Joon Seok
AU - Yeh, Elaine
AU - Schnurr, David
AU - Hood, Ron
AU - Hunter, Willard
AU - Madigan, John E
PY - 1999
Y1 - 1999
N2 - We report two cases of human granulocytic ehrlichiosis (HGE) that occurred in northern California in summer 1998. Patients had fever, malaise, and myalgia, reported tick bites, had moderate thrombocytopenia, and had normal or slightly elevated liver enzyme activities. Ehrlichial inclusions were observed in the blood of one patient, and HGE-agent DNA was amplified by PCR from both patients. Genetically, the strains resembled horse isolates from northern California. The close spatial and temporal proximity of the two new cases may be due to a nidus of infection in the area or heightened surveillance by local physicians.
AB - We report two cases of human granulocytic ehrlichiosis (HGE) that occurred in northern California in summer 1998. Patients had fever, malaise, and myalgia, reported tick bites, had moderate thrombocytopenia, and had normal or slightly elevated liver enzyme activities. Ehrlichial inclusions were observed in the blood of one patient, and HGE-agent DNA was amplified by PCR from both patients. Genetically, the strains resembled horse isolates from northern California. The close spatial and temporal proximity of the two new cases may be due to a nidus of infection in the area or heightened surveillance by local physicians.
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M3 - Article
C2 - 10476747
AN - SCOPUS:0032770843
VL - 29
SP - 388
EP - 392
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 2
ER -