Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences

V. Colonna, Q. Ayub, Y. Chen, L. Pagani, P. Luisi, M. Pybus, E. Garrison, Y. Xue, C. Tyler-Smith, G. R. Abecasis, A. Auton, L. D. Brooks, M. A. Depristo, R. M. Durbin, R. E. Handsaker, H. M. Kang, G. T. Marth, Ga McVean, D. M. Altshuler, R. M. DurbinG. R. Abecasis, D. R. Bentley, A. Chakravarti, A. G. Clark, P. Donnelly, E. E. Eichler, P. Flicek, S. B. Gabriel, R. A. Gibbs, E. D. Green, M. E. Hurles, B. M. Knoppers, J. O. Korbel, E. S. Lander, C. Lee, H. Lehrach, E. R. Mardis, G. T. Marth, G. A. McVean, D. A. Nickerson, J. P. Schmidt, S. T. Sherry, J. Wang, R. K. Wilson, R. A. Gibbs, H. Dinh, C. Kovar, S. Lee, L. Lewis, D. Muzny, J. Reid, M. Wang, J. Wang, X. Fang, X. Guo, M. Jian, H. Jiang, X. Jin, G. Li, J. Li, Y. Li, Z. Li, X. Liu, Y. Lu, X. Ma, Z. Su, S. Tai, M. Tang, B. Wang, G. Wang, H. Wu, R. Wu, Y. Yin, W. Zhang, J. Zhao, M. Zhao, X. Zheng, Y. Zhou, E. S. Lander, D. M. Altshuler, S. B. Gabriel, N. Gupta, P. Flicek, L. Clarke, R. Leinonen, R. E. Smith, X. Zheng-Bradley, D. R. Bentley, R. Grocock, S. Humphray, T. James, Z. Kingsbury, H. Lehrach, R. Sudbrak, M. W. Albrecht, V. S. Amstislavskiy, T. A. Borodina, M. Lienhard, F. Mertes, M. Sultan, B. Timmermann, M. L. Yaspo, S. T. Sherry, G. A. McVean, E. R. Mardis, R. K. Wilson, L. Fulton, R. Fulton, G. M. Weinstock, R. M. Durbin, S. Balasubramaniam, J. Burton, P. Danecek, T. M. Keane, A. Kolb-Kokocinski, S. McCarthy, J. Stalker, M. Quail, J. P. Schmidt, C. J. Davies, J. Gollub, T. Webster, B. Wong, Y. Zhan, A. Auton, R. A. Gibbs, F. Yu, M. Bainbridge, D. Challis, U. S. Evani, J. Lu, D. Muzny, U. Nagaswamy, J. Reid, A. Sabo, Y. Wang, J. Yu, J. Wang, L. J. Coin, L. Fang, X. Guo, X. Jin, G. Li, Q. Li, Y. Li, Z. Li, H. Lin, B. Liu, R. Luo, N. Qin, H. Shao, B. Wang, Y. Xie, C. Ye, C. Yu, F. Zhang, H. Zheng, H. Zhu, G. T. Marth, E. P. Garrison, D. Kural, W. P. Lee, W. F. Leong, A. N. Ward, J. Wu, M. Zhang, C. Lee, L. Griffin, C. H. Hsieh, R. E. Mills, X. Shi, M. von Grotthuss, C. Zhang, M. J. Daly, M. A. Depristo, D. M. Altshuler, E. Banks, G. Bhatia, M. O. Carneiro, G. Del Angel, S. B. Gabriel, G. Genovese, N. Gupta, R. E. Handsaker, C. Hartl, E. S. Lander, S. A. McCarroll, J. C. Nemesh, R. E. Poplin, S. F. Schaffner, K. Shakir, S. C. Yoon, J. Lihm, V. Makarov, H. Jin, W. Kim, K. C. Kim, J. O. Korbel, T. Rausch, P. Flicek, K. Beal, L. Clarke, F. Cunningham, J. Herrero, W. M. McLaren, G. R. Ritchie, R. E. Smith, X. Zheng-Bradley, A. G. Clark, S. Gottipati, A. Keinan, J. L. Rodriguez-Flores, P. C. Sabeti, S. R. Grossman, S. Tabrizi, R. Tariyal, D. N. Cooper, E. V. Ball, P. D. Stenson, D. R. Bentley, B. Barnes, M. Bauer, R. Cheetham, T. Cox, M. Eberle, S. Humphray, S. Kahn, L. Murray, J. Peden, R. Shaw, K. Ye, M. A. Batzer, M. K. Konkel, J. A. Walker, D. G. Macarthur, M. Lek, R. Sudbrak, V. S. Amstislavskiy, R. Herwig, M. D. Shriver, C. D. Bustamante, J. K. Byrnes, F. M. De La Vega, S. Gravel, E. E. Kenny, J. M. Kidd, P. Lacroute, B. K. Maples, A. Moreno-Estrada, F. Zakharia, E. Halperin, Y. Baran, D. W. Craig, A. Christoforides, N. Homer, T. Izatt, A. A. Kurdoglu, S. A. Sinari, K. Squire, S. T. Sherry, C. Xiao, J. Sebat, V. Bafna, K. Ye, E. G. Burchard, R. D. Hernandez, C. R. Gignoux, D. Haussler, Fereydoun Hormozdiari, W. J. Kent, B. Howie, A. Ruiz-Linares, E. T. Dermitzakis, T. Lappalainen, S. E. Devine, X. Liu, A. Maroo, L. J. Tallon, J. A. Rosenfeld, L. P. Michelson, P. Anderson, A. Angius, A. Bigham, T. Blackwell, F. Busonero, Francesco Cucca, C. Fuchsberger, C. Jones, Y. Li, R. Lyons, A. Maschio, E. Porcu, F. Reinier, S. Sanna, D. Schlessinger, C. Sidore, A. Tan, M. K. Trost, P. Awadalla, A. Hodgkinson, G. Lunter, G. A. McVean, J. L. Marchini, S. Myers, C. Churchhouse, O. Delaneau, A. Gupta-Hinch, Z. Iqbal, I. Mathieson, A. Rimmer, D. K. Xifara, T. K. Oleksyk, Y. Fu, X. Liu, M. Xiong, L. Jorde, D. Witherspoon, J. Xing, B. L. Browning, C. Alkan, I. Hajirasouliha, F. Hormozdiari, A. Ko, P. H. Sudmant, E. R. Mardis, K. Chen, A. Chinwalla, L. Ding, D. Dooling, D. C. Koboldt, M. D. McLellan, J. W. Wallis, M. C. Wendl, Q. Zhang, R. M. Durbin, M. E. Hurles, C. Tyler-Smith, C. A. Albers, Q. Ayub, S. Balasubramaniam, Y. Chen, A. J. Coffey, V. Colonna, P. Danecek, N. Huang, L. Jostins, T. M. Keane, H. Li, S. McCarthy, A. Scally, J. Stalker, K. Walter, Y. Xue, Y. Zhang, M. B. Gerstein, A. Abyzov, S. Balasubramanian, J. Chen, D. Clarke, Y. Fu, L. Habegger, A. O. Harmanci, M. Jin, E. Khurana, X. J. Mu, C. Sisu, Y. Li, R. Luo, H. Zhu, C. Lee, L. Griffin, C. H. Hsieh, R. E. Mills, X. Shi, M. von Grotthuss, C. Zhang, G. T. Marth, E. P. Garrison, D. Kural, W. P. Lee, A. N. Ward, J. Wu, M. Zhang, S. A. McCarroll, D. M. Altshuler, E. Banks, G. Del Angel, G. Genovese, R. E. Handsaker, C. Hartl, J. C. Nemesh, K. Shakir, S. C. Yoon, J. Lihm, V. Makarov, J. Degenhardt, P. Flicek, L. Clarke, R. E. Smith, X. Zheng-Bradley, J. O. Korbel, T. Rausch, A. M. Stütz, D. R. Bentley, B. Barnes, R. Cheetham, M. Eberle, S. Humphray, S. Kahn, L. Murray, R. Shaw, K. Ye, M. A. Batzer, M. K. Konkel, J. A. Walker, P. Lacroute, D. W. Craig, N. Homer, D. Church, C. Xiao, J. Sebat, V. Bafna, J. J. Michaelson, K. Ye, S. E. Devine, X. Liu, A. Maroo, L. J. Tallon, G. Lunter, G. A. McVean, Z. Iqbal, D. Witherspoon, J. Xing, E. E. Eichler, C. Alkan, I. Hajirasouliha, F. Hormozdiari, A. Ko, P. H. Sudmant, K. Chen, A. Chinwalla, L. Ding, M. D. McLellan, J. W. Wallis, M. E. Hurles, B. Blackburne, H. Li, S. J. Lindsay, Z. Ning, A. Scally, K. Walter, Y. Zhang, M. B. Gerstein, A. Abyzov, J. Chen, D. Clarke, E. Khurana, X. J. Mu, C. Sisu, R. A. Gibbs, F. Yu, M. Bainbridge, D. Challis, U. S. Evani, C. Kovar, L. Lewis, J. Lu, D. Muzny, U. Nagaswamy, J. Reid, A. Sabo, J. Yu, X. Guo, Y. Li, R. Wu, G. T. Marth, E. P. Garrison, W. F. Leong, A. N. Ward, G. Del Angel, M. A. Depristo, S. B. Gabriel, N. Gupta, C. Hartl, R. E. Poplin, A. G. Clark, J. L. Rodriguez-Flores, P. Flicek, L. Clarke, R. E. Smith, X. Zheng-Bradley, D. G. Macarthur, C. D. Bustamante, S. Gravel, D. W. Craig, A. Christoforides, N. Homer, T. Izatt, S. T. Sherry, C. Xiao, E. Dermitzakis, G. R. Abecasis, H. M. Kang, G. A. McVean, E. R. Mardis, D. Dooling, L. Fulton, R. Fulton, D. C. Koboldt, R. M. Durbin, S. Balasubramaniam, T. M. Keane, S. McCarthy, J. Stalker, M. B. Gerstein, S. Balasubramanian, L. Habegger, E. P. Garrison, R. A. Gibbs, M. Bainbridge, D. Muzny, F. Yu, J. Yu, G. Del Angel, R. E. Handsaker, V. Makarov, J. L. Rodriguez-Flores, H. Jin, W. Kim, K. C. Kim, P. Flicek, K. Beal, L. Clarke, F. Cunningham, J. Herrero, W. M. McLaren, G. R. Ritchie, X. Zheng-Bradley, S. Tabrizi, D. G. Macarthur, M. Lek, C. D. Bustamante, F. M. De La Vega, D. W. Craig, A. A. Kurdoglu, T. Lappalainen, J. A. Rosenfeld, L. P. Michelson, P. Awadalla, A. Hodgkinson, G. A. McVean, K. Chen, C. Tyler-Smith, Y. Chen, V. Colonna, A. Frankish, J. Harrow, Y. Xue, M. B. Gerstein, A. Abyzov, S. Balasubramanian, J. Chen, D. Clarke, Y. Fu, A. O. Harmanci, M. Jin, E. Khurana, X. J. Mu, C. Sisu, R. A. Gibbs, C. Kovar, D. Kalra, W. Hale, G. Fowler, D. Muzny, J. Reid, J. Wang, X. Guo, G. Li, Y. Li, X. Zheng, D. M. Altshuler, P. Flicek, L. Clarke, J. Barker, G. Kelman, E. Kulesha, R. Leinonen, W. M. McLaren, R. Radhakrishnan, A. Roa, D. Smirnov, R. E. Smith, I. Streeter, I. Toneva, B. Vaughan, X. Zheng-Bradley, D. R. Bentley, T. Cox, S. Humphray, S. Kahn, R. Sudbrak, M. W. Albrecht, M. Lienhard, D. W. Craig, T. Izatt, A. A. Kurdoglu, S. T. Sherry, V. Ananiev, Z. Belaia, D. Beloslyudtsev, N. Bouk, C. Chen, D. Church, R. Cohen, C. Cook, J. Garner, T. Hefferon, M. Kimelman, C. Liu, J. Lopez, P. Meric, C. O'sullivan, Y. Ostapchuk, S. Ponomarov, V. Schneider, E. Shekhtman, K. Sirotkin, D. Slotta, C. Xiao, H. Zhang, D. Haussler, G. R. Abecasis, G. A. McVean, C. Alkan, A. Ko, D. Dooling, R. M. Durbin, S. Balasubramaniam, T. M. Keane, S. McCarthy, J. Stalker, A. Chakravarti, G. R. Abecasis, K. C. Barnes, C. Beiswanger, E. Burchard, C. D. Bustamante, H. Cai, H. Cao, R. M. Durbin, N. Gharani, R. A. Gibbs, C. R. Gignoux, S. Gravel, B. Henn, D. Jones, L. Jorde, J. S. Kaye, A. Keinan, A. Kent, A. Kerasidou, Y. Li, R. Mathias, G. McVean, A. Moreno-Estrada, P. N. Ossorio, M. Parker, D. Reich, C. N. Rotimi, C. D. Royal, K. Sandoval, Y. Su, R. Sudbrak, Z. Tian, B. Timmermann, S. Tishkoff, L. H. Toji, C. Tyler-Smith, M. Via, Y. Wang, H. Yang, L. Yang, J. Zhu, W. Bodmer, G. Bedoya, A. Ruiz-Linares, C. Z. Ming, G. Yang, C. J. You, L. Peltonen, A. Garcia-Montero, A. Orfao, J. Dutil, J. C. Martinez-Cruzado, T. K. Oleksyk, L. D. Brooks, A. L. Felsenfeld, J. E. McEwen, N. C. Clemm, A. Duncanson, M. Dunn, E. D. Green, M. S. Guyer, J. L. Peterson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we extend this dataset to include additional variants, survey sites with low levels of differentiation, and evaluate the extent to which highly differentiated sites are likely to result from selective or other processes. Results: We demonstrate that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high population differentiation are enriched for positive selection events and that one half may be the result of classic selective sweeps. Among these, we rediscover known examples, where we actually identify the established functional SNP, and discover novel examples including the genes ABCA12, CALD1 and ZNF804, which we speculate may be linked to adaptations in skin, calcium metabolism and defense, respectively. Conclusions: We identify known and many novel candidate regions for geographically restricted positive selection, and suggest several directions for further research.

Original languageEnglish (US)
Article numberR88
JournalGenome Biology
Volume15
Issue number6
DOIs
StatePublished - Jun 30 2014
Externally publishedYes

Fingerprint

genomics
genome
Genome
loci
skin (animal)
human population
Population
calcium
genetic variation
metabolism
Single Nucleotide Polymorphism
site selection
genetic differentiation
Calcium
skin
Skin
genes
Research
sampling
Genes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences. / Colonna, V.; Ayub, Q.; Chen, Y.; Pagani, L.; Luisi, P.; Pybus, M.; Garrison, E.; Xue, Y.; Tyler-Smith, C.; Abecasis, G. R.; Auton, A.; Brooks, L. D.; Depristo, M. A.; Durbin, R. M.; Handsaker, R. E.; Kang, H. M.; Marth, G. T.; McVean, Ga; Altshuler, D. M.; Durbin, R. M.; Abecasis, G. R.; Bentley, D. R.; Chakravarti, A.; Clark, A. G.; Donnelly, P.; Eichler, E. E.; Flicek, P.; Gabriel, S. B.; Gibbs, R. A.; Green, E. D.; Hurles, M. E.; Knoppers, B. M.; Korbel, J. O.; Lander, E. S.; Lee, C.; Lehrach, H.; Mardis, E. R.; Marth, G. T.; McVean, G. A.; Nickerson, D. A.; Schmidt, J. P.; Sherry, S. T.; Wang, J.; Wilson, R. K.; Gibbs, R. A.; Dinh, H.; Kovar, C.; Lee, S.; Lewis, L.; Muzny, D.; Reid, J.; Wang, M.; Wang, J.; Fang, X.; Guo, X.; Jian, M.; Jiang, H.; Jin, X.; Li, G.; Li, J.; Li, Y.; Li, Z.; Liu, X.; Lu, Y.; Ma, X.; Su, Z.; Tai, S.; Tang, M.; Wang, B.; Wang, G.; Wu, H.; Wu, R.; Yin, Y.; Zhang, W.; Zhao, J.; Zhao, M.; Zheng, X.; Zhou, Y.; Lander, E. S.; Altshuler, D. M.; Gabriel, S. B.; Gupta, N.; Flicek, P.; Clarke, L.; Leinonen, R.; Smith, R. E.; Zheng-Bradley, X.; Bentley, D. R.; Grocock, R.; Humphray, S.; James, T.; Kingsbury, Z.; Lehrach, H.; Sudbrak, R.; Albrecht, M. W.; Amstislavskiy, V. S.; Borodina, T. A.; Lienhard, M.; Mertes, F.; Sultan, M.; Timmermann, B.; Yaspo, M. L.; Sherry, S. T.; McVean, G. A.; Mardis, E. R.; Wilson, R. K.; Fulton, L.; Fulton, R.; Weinstock, G. M.; Durbin, R. M.; Balasubramaniam, S.; Burton, J.; Danecek, P.; Keane, T. M.; Kolb-Kokocinski, A.; McCarthy, S.; Stalker, J.; Quail, M.; Schmidt, J. P.; Davies, C. J.; Gollub, J.; Webster, T.; Wong, B.; Zhan, Y.; Auton, A.; Gibbs, R. A.; Yu, F.; Bainbridge, M.; Challis, D.; Evani, U. S.; Lu, J.; Muzny, D.; Nagaswamy, U.; Reid, J.; Sabo, A.; Wang, Y.; Yu, J.; Wang, J.; Coin, L. J.; Fang, L.; Guo, X.; Jin, X.; Li, G.; Li, Q.; Li, Y.; Li, Z.; Lin, H.; Liu, B.; Luo, R.; Qin, N.; Shao, H.; Wang, B.; Xie, Y.; Ye, C.; Yu, C.; Zhang, F.; Zheng, H.; Zhu, H.; Marth, G. T.; Garrison, E. P.; Kural, D.; Lee, W. P.; Leong, W. F.; Ward, A. N.; Wu, J.; Zhang, M.; Lee, C.; Griffin, L.; Hsieh, C. H.; Mills, R. E.; Shi, X.; von Grotthuss, M.; Zhang, C.; Daly, M. J.; Depristo, M. A.; Altshuler, D. M.; Banks, E.; Bhatia, G.; Carneiro, M. O.; Del Angel, G.; Gabriel, S. B.; Genovese, G.; Gupta, N.; Handsaker, R. E.; Hartl, C.; Lander, E. S.; McCarroll, S. A.; Nemesh, J. C.; Poplin, R. E.; Schaffner, S. F.; Shakir, K.; Yoon, S. C.; Lihm, J.; Makarov, V.; Jin, H.; Kim, W.; Kim, K. C.; Korbel, J. O.; Rausch, T.; Flicek, P.; Beal, K.; Clarke, L.; Cunningham, F.; Herrero, J.; McLaren, W. M.; Ritchie, G. R.; Smith, R. E.; Zheng-Bradley, X.; Clark, A. G.; Gottipati, S.; Keinan, A.; Rodriguez-Flores, J. L.; Sabeti, P. C.; Grossman, S. R.; Tabrizi, S.; Tariyal, R.; Cooper, D. N.; Ball, E. V.; Stenson, P. D.; Bentley, D. R.; Barnes, B.; Bauer, M.; Cheetham, R.; Cox, T.; Eberle, M.; Humphray, S.; Kahn, S.; Murray, L.; Peden, J.; Shaw, R.; Ye, K.; Batzer, M. A.; Konkel, M. K.; Walker, J. A.; Macarthur, D. G.; Lek, M.; Sudbrak, R.; Amstislavskiy, V. S.; Herwig, R.; Shriver, M. D.; Bustamante, C. D.; Byrnes, J. K.; De La Vega, F. M.; Gravel, S.; Kenny, E. E.; Kidd, J. M.; Lacroute, P.; Maples, B. K.; Moreno-Estrada, A.; Zakharia, F.; Halperin, E.; Baran, Y.; Craig, D. W.; Christoforides, A.; Homer, N.; Izatt, T.; Kurdoglu, A. A.; Sinari, S. A.; Squire, K.; Sherry, S. T.; Xiao, C.; Sebat, J.; Bafna, V.; Ye, K.; Burchard, E. G.; Hernandez, R. D.; Gignoux, C. R.; Haussler, D.; Hormozdiari, Fereydoun; Kent, W. J.; Howie, B.; Ruiz-Linares, A.; Dermitzakis, E. T.; Lappalainen, T.; Devine, S. E.; Liu, X.; Maroo, A.; Tallon, L. J.; Rosenfeld, J. A.; Michelson, L. P.; Anderson, P.; Angius, A.; Bigham, A.; Blackwell, T.; Busonero, F.; Cucca, Francesco; Fuchsberger, C.; Jones, C.; Li, Y.; Lyons, R.; Maschio, A.; Porcu, E.; Reinier, F.; Sanna, S.; Schlessinger, D.; Sidore, C.; Tan, A.; Trost, M. K.; Awadalla, P.; Hodgkinson, A.; Lunter, G.; McVean, G. A.; Marchini, J. L.; Myers, S.; Churchhouse, C.; Delaneau, O.; Gupta-Hinch, A.; Iqbal, Z.; Mathieson, I.; Rimmer, A.; Xifara, D. K.; Oleksyk, T. K.; Fu, Y.; Liu, X.; Xiong, M.; Jorde, L.; Witherspoon, D.; Xing, J.; Browning, B. L.; Alkan, C.; Hajirasouliha, I.; Hormozdiari, F.; Ko, A.; Sudmant, P. H.; Mardis, E. R.; Chen, K.; Chinwalla, A.; Ding, L.; Dooling, D.; Koboldt, D. C.; McLellan, M. D.; Wallis, J. W.; Wendl, M. C.; Zhang, Q.; Durbin, R. M.; Hurles, M. E.; Tyler-Smith, C.; Albers, C. A.; Ayub, Q.; Balasubramaniam, S.; Chen, Y.; Coffey, A. J.; Colonna, V.; Danecek, P.; Huang, N.; Jostins, L.; Keane, T. M.; Li, H.; McCarthy, S.; Scally, A.; Stalker, J.; Walter, K.; Xue, Y.; Zhang, Y.; Gerstein, M. B.; Abyzov, A.; Balasubramanian, S.; Chen, J.; Clarke, D.; Fu, Y.; Habegger, L.; Harmanci, A. O.; Jin, M.; Khurana, E.; Mu, X. J.; Sisu, C.; Li, Y.; Luo, R.; Zhu, H.; Lee, C.; Griffin, L.; Hsieh, C. H.; Mills, R. E.; Shi, X.; von Grotthuss, M.; Zhang, C.; Marth, G. T.; Garrison, E. P.; Kural, D.; Lee, W. P.; Ward, A. N.; Wu, J.; Zhang, M.; McCarroll, S. A.; Altshuler, D. M.; Banks, E.; Del Angel, G.; Genovese, G.; Handsaker, R. E.; Hartl, C.; Nemesh, J. C.; Shakir, K.; Yoon, S. C.; Lihm, J.; Makarov, V.; Degenhardt, J.; Flicek, P.; Clarke, L.; Smith, R. E.; Zheng-Bradley, X.; Korbel, J. O.; Rausch, T.; Stütz, A. M.; Bentley, D. R.; Barnes, B.; Cheetham, R.; Eberle, M.; Humphray, S.; Kahn, S.; Murray, L.; Shaw, R.; Ye, K.; Batzer, M. A.; Konkel, M. K.; Walker, J. A.; Lacroute, P.; Craig, D. W.; Homer, N.; Church, D.; Xiao, C.; Sebat, J.; Bafna, V.; Michaelson, J. J.; Ye, K.; Devine, S. E.; Liu, X.; Maroo, A.; Tallon, L. J.; Lunter, G.; McVean, G. A.; Iqbal, Z.; Witherspoon, D.; Xing, J.; Eichler, E. E.; Alkan, C.; Hajirasouliha, I.; Hormozdiari, F.; Ko, A.; Sudmant, P. H.; Chen, K.; Chinwalla, A.; Ding, L.; McLellan, M. D.; Wallis, J. W.; Hurles, M. E.; Blackburne, B.; Li, H.; Lindsay, S. J.; Ning, Z.; Scally, A.; Walter, K.; Zhang, Y.; Gerstein, M. B.; Abyzov, A.; Chen, J.; Clarke, D.; Khurana, E.; Mu, X. J.; Sisu, C.; Gibbs, R. A.; Yu, F.; Bainbridge, M.; Challis, D.; Evani, U. S.; Kovar, C.; Lewis, L.; Lu, J.; Muzny, D.; Nagaswamy, U.; Reid, J.; Sabo, A.; Yu, J.; Guo, X.; Li, Y.; Wu, R.; Marth, G. T.; Garrison, E. P.; Leong, W. F.; Ward, A. N.; Del Angel, G.; Depristo, M. A.; Gabriel, S. B.; Gupta, N.; Hartl, C.; Poplin, R. E.; Clark, A. G.; Rodriguez-Flores, J. L.; Flicek, P.; Clarke, L.; Smith, R. E.; Zheng-Bradley, X.; Macarthur, D. G.; Bustamante, C. D.; Gravel, S.; Craig, D. W.; Christoforides, A.; Homer, N.; Izatt, T.; Sherry, S. T.; Xiao, C.; Dermitzakis, E.; Abecasis, G. R.; Kang, H. M.; McVean, G. A.; Mardis, E. R.; Dooling, D.; Fulton, L.; Fulton, R.; Koboldt, D. C.; Durbin, R. M.; Balasubramaniam, S.; Keane, T. M.; McCarthy, S.; Stalker, J.; Gerstein, M. B.; Balasubramanian, S.; Habegger, L.; Garrison, E. P.; Gibbs, R. A.; Bainbridge, M.; Muzny, D.; Yu, F.; Yu, J.; Del Angel, G.; Handsaker, R. E.; Makarov, V.; Rodriguez-Flores, J. L.; Jin, H.; Kim, W.; Kim, K. C.; Flicek, P.; Beal, K.; Clarke, L.; Cunningham, F.; Herrero, J.; McLaren, W. M.; Ritchie, G. R.; Zheng-Bradley, X.; Tabrizi, S.; Macarthur, D. G.; Lek, M.; Bustamante, C. D.; De La Vega, F. M.; Craig, D. W.; Kurdoglu, A. A.; Lappalainen, T.; Rosenfeld, J. A.; Michelson, L. P.; Awadalla, P.; Hodgkinson, A.; McVean, G. A.; Chen, K.; Tyler-Smith, C.; Chen, Y.; Colonna, V.; Frankish, A.; Harrow, J.; Xue, Y.; Gerstein, M. B.; Abyzov, A.; Balasubramanian, S.; Chen, J.; Clarke, D.; Fu, Y.; Harmanci, A. O.; Jin, M.; Khurana, E.; Mu, X. J.; Sisu, C.; Gibbs, R. A.; Kovar, C.; Kalra, D.; Hale, W.; Fowler, G.; Muzny, D.; Reid, J.; Wang, J.; Guo, X.; Li, G.; Li, Y.; Zheng, X.; Altshuler, D. M.; Flicek, P.; Clarke, L.; Barker, J.; Kelman, G.; Kulesha, E.; Leinonen, R.; McLaren, W. M.; Radhakrishnan, R.; Roa, A.; Smirnov, D.; Smith, R. E.; Streeter, I.; Toneva, I.; Vaughan, B.; Zheng-Bradley, X.; Bentley, D. R.; Cox, T.; Humphray, S.; Kahn, S.; Sudbrak, R.; Albrecht, M. W.; Lienhard, M.; Craig, D. W.; Izatt, T.; Kurdoglu, A. A.; Sherry, S. T.; Ananiev, V.; Belaia, Z.; Beloslyudtsev, D.; Bouk, N.; Chen, C.; Church, D.; Cohen, R.; Cook, C.; Garner, J.; Hefferon, T.; Kimelman, M.; Liu, C.; Lopez, J.; Meric, P.; O'sullivan, C.; Ostapchuk, Y.; Ponomarov, S.; Schneider, V.; Shekhtman, E.; Sirotkin, K.; Slotta, D.; Xiao, C.; Zhang, H.; Haussler, D.; Abecasis, G. R.; McVean, G. A.; Alkan, C.; Ko, A.; Dooling, D.; Durbin, R. M.; Balasubramaniam, S.; Keane, T. M.; McCarthy, S.; Stalker, J.; Chakravarti, A.; Abecasis, G. R.; Barnes, K. C.; Beiswanger, C.; Burchard, E.; Bustamante, C. D.; Cai, H.; Cao, H.; Durbin, R. M.; Gharani, N.; Gibbs, R. A.; Gignoux, C. R.; Gravel, S.; Henn, B.; Jones, D.; Jorde, L.; Kaye, J. S.; Keinan, A.; Kent, A.; Kerasidou, A.; Li, Y.; Mathias, R.; McVean, G.; Moreno-Estrada, A.; Ossorio, P. N.; Parker, M.; Reich, D.; Rotimi, C. N.; Royal, C. D.; Sandoval, K.; Su, Y.; Sudbrak, R.; Tian, Z.; Timmermann, B.; Tishkoff, S.; Toji, L. H.; Tyler-Smith, C.; Via, M.; Wang, Y.; Yang, H.; Yang, L.; Zhu, J.; Bodmer, W.; Bedoya, G.; Ruiz-Linares, A.; Ming, C. Z.; Yang, G.; You, C. J.; Peltonen, L.; Garcia-Montero, A.; Orfao, A.; Dutil, J.; Martinez-Cruzado, J. C.; Oleksyk, T. K.; Brooks, L. D.; Felsenfeld, A. L.; McEwen, J. E.; Clemm, N. C.; Duncanson, A.; Dunn, M.; Green, E. D.; Guyer, M. S.; Peterson, J. L.

In: Genome Biology, Vol. 15, No. 6, R88, 30.06.2014.

Research output: Contribution to journalArticle

Colonna, V, Ayub, Q, Chen, Y, Pagani, L, Luisi, P, Pybus, M, Garrison, E, Xue, Y, Tyler-Smith, C, Abecasis, GR, Auton, A, Brooks, LD, Depristo, MA, Durbin, RM, Handsaker, RE, Kang, HM, Marth, GT, McVean, G, Altshuler, DM, Durbin, RM, Abecasis, GR, Bentley, DR, Chakravarti, A, Clark, AG, Donnelly, P, Eichler, EE, Flicek, P, Gabriel, SB, Gibbs, RA, Green, ED, Hurles, ME, Knoppers, BM, Korbel, JO, Lander, ES, Lee, C, Lehrach, H, Mardis, ER, Marth, GT, McVean, GA, Nickerson, DA, Schmidt, JP, Sherry, ST, Wang, J, Wilson, RK, Gibbs, RA, Dinh, H, Kovar, C, Lee, S, Lewis, L, Muzny, D, Reid, J, Wang, M, Wang, J, Fang, X, Guo, X, Jian, M, Jiang, H, Jin, X, Li, G, Li, J, Li, Y, Li, Z, Liu, X, Lu, Y, Ma, X, Su, Z, Tai, S, Tang, M, Wang, B, Wang, G, Wu, H, Wu, R, Yin, Y, Zhang, W, Zhao, J, Zhao, M, Zheng, X, Zhou, Y, Lander, ES, Altshuler, DM, Gabriel, SB, Gupta, N, Flicek, P, Clarke, L, Leinonen, R, Smith, RE, Zheng-Bradley, X, Bentley, DR, Grocock, R, Humphray, S, James, T, Kingsbury, Z, Lehrach, H, Sudbrak, R, Albrecht, MW, Amstislavskiy, VS, Borodina, TA, Lienhard, M, Mertes, F, Sultan, M, Timmermann, B, Yaspo, ML, Sherry, ST, McVean, GA, Mardis, ER, Wilson, RK, Fulton, L, Fulton, R, Weinstock, GM, Durbin, RM, Balasubramaniam, S, Burton, J, Danecek, P, Keane, TM, Kolb-Kokocinski, A, McCarthy, S, Stalker, J, Quail, M, Schmidt, JP, Davies, CJ, Gollub, J, Webster, T, Wong, B, Zhan, Y, Auton, A, Gibbs, RA, Yu, F, Bainbridge, M, Challis, D, Evani, US, Lu, J, Muzny, D, Nagaswamy, U, Reid, J, Sabo, A, Wang, Y, Yu, J, Wang, J, Coin, LJ, Fang, L, Guo, X, Jin, X, Li, G, Li, Q, Li, Y, Li, Z, Lin, H, Liu, B, Luo, R, Qin, N, Shao, H, Wang, B, Xie, Y, Ye, C, Yu, C, Zhang, F, Zheng, H, Zhu, H, Marth, GT, Garrison, EP, Kural, D, Lee, WP, Leong, WF, Ward, AN, Wu, J, Zhang, M, Lee, C, Griffin, L, Hsieh, CH, Mills, RE, Shi, X, von Grotthuss, M, Zhang, C, Daly, MJ, Depristo, MA, Altshuler, DM, Banks, E, Bhatia, G, Carneiro, MO, Del Angel, G, Gabriel, SB, Genovese, G, Gupta, N, Handsaker, RE, Hartl, C, Lander, ES, McCarroll, SA, Nemesh, JC, Poplin, RE, Schaffner, SF, Shakir, K, Yoon, SC, Lihm, J, Makarov, V, Jin, H, Kim, W, Kim, KC, Korbel, JO, Rausch, T, Flicek, P, Beal, K, Clarke, L, Cunningham, F, Herrero, J, McLaren, WM, Ritchie, GR, Smith, RE, Zheng-Bradley, X, Clark, AG, Gottipati, S, Keinan, A, Rodriguez-Flores, JL, Sabeti, PC, Grossman, SR, Tabrizi, S, Tariyal, R, Cooper, DN, Ball, EV, Stenson, PD, Bentley, DR, Barnes, B, Bauer, M, Cheetham, R, Cox, T, Eberle, M, Humphray, S, Kahn, S, Murray, L, Peden, J, Shaw, R, Ye, K, Batzer, MA, Konkel, MK, Walker, JA, Macarthur, DG, Lek, M, Sudbrak, R, Amstislavskiy, VS, Herwig, R, Shriver, MD, Bustamante, CD, Byrnes, JK, De La Vega, FM, Gravel, S, Kenny, EE, Kidd, JM, Lacroute, P, Maples, BK, Moreno-Estrada, A, Zakharia, F, Halperin, E, Baran, Y, Craig, DW, Christoforides, A, Homer, N, Izatt, T, Kurdoglu, AA, Sinari, SA, Squire, K, Sherry, ST, Xiao, C, Sebat, J, Bafna, V, Ye, K, Burchard, EG, Hernandez, RD, Gignoux, CR, Haussler, D, Hormozdiari, F, Kent, WJ, Howie, B, Ruiz-Linares, A, Dermitzakis, ET, Lappalainen, T, Devine, SE, Liu, X, Maroo, A, Tallon, LJ, Rosenfeld, JA, Michelson, LP, Anderson, P, Angius, A, Bigham, A, Blackwell, T, Busonero, F, Cucca, F, Fuchsberger, C, Jones, C, Li, Y, Lyons, R, Maschio, A, Porcu, E, Reinier, F, Sanna, S, Schlessinger, D, Sidore, C, Tan, A, Trost, MK, Awadalla, P, Hodgkinson, A, Lunter, G, McVean, GA, Marchini, JL, Myers, S, Churchhouse, C, Delaneau, O, Gupta-Hinch, A, Iqbal, Z, Mathieson, I, Rimmer, A, Xifara, DK, Oleksyk, TK, Fu, Y, Liu, X, Xiong, M, Jorde, L, Witherspoon, D, Xing, J, Browning, BL, Alkan, C, Hajirasouliha, I, Hormozdiari, F, Ko, A, Sudmant, PH, Mardis, ER, Chen, K, Chinwalla, A, Ding, L, Dooling, D, Koboldt, DC, McLellan, MD, Wallis, JW, Wendl, MC, Zhang, Q, Durbin, RM, Hurles, ME, Tyler-Smith, C, Albers, CA, Ayub, Q, Balasubramaniam, S, Chen, Y, Coffey, AJ, Colonna, V, Danecek, P, Huang, N, Jostins, L, Keane, TM, Li, H, McCarthy, S, Scally, A, Stalker, J, Walter, K, Xue, Y, Zhang, Y, Gerstein, MB, Abyzov, A, Balasubramanian, S, Chen, J, Clarke, D, Fu, Y, Habegger, L, Harmanci, AO, Jin, M, Khurana, E, Mu, XJ, Sisu, C, Li, Y, Luo, R, Zhu, H, Lee, C, Griffin, L, Hsieh, CH, Mills, RE, Shi, X, von Grotthuss, M, Zhang, C, Marth, GT, Garrison, EP, Kural, D, Lee, WP, Ward, AN, Wu, J, Zhang, M, McCarroll, SA, Altshuler, DM, Banks, E, Del Angel, G, Genovese, G, Handsaker, RE, Hartl, C, Nemesh, JC, Shakir, K, Yoon, SC, Lihm, J, Makarov, V, Degenhardt, J, Flicek, P, Clarke, L, Smith, RE, Zheng-Bradley, X, Korbel, JO, Rausch, T, Stütz, AM, Bentley, DR, Barnes, B, Cheetham, R, Eberle, M, Humphray, S, Kahn, S, Murray, L, Shaw, R, Ye, K, Batzer, MA, Konkel, MK, Walker, JA, Lacroute, P, Craig, DW, Homer, N, Church, D, Xiao, C, Sebat, J, Bafna, V, Michaelson, JJ, Ye, K, Devine, SE, Liu, X, Maroo, A, Tallon, LJ, Lunter, G, McVean, GA, Iqbal, Z, Witherspoon, D, Xing, J, Eichler, EE, Alkan, C, Hajirasouliha, I, Hormozdiari, F, Ko, A, Sudmant, PH, Chen, K, Chinwalla, A, Ding, L, McLellan, MD, Wallis, JW, Hurles, ME, Blackburne, B, Li, H, Lindsay, SJ, Ning, Z, Scally, A, Walter, K, Zhang, Y, Gerstein, MB, Abyzov, A, Chen, J, Clarke, D, Khurana, E, Mu, XJ, Sisu, C, Gibbs, RA, Yu, F, Bainbridge, M, Challis, D, Evani, US, Kovar, C, Lewis, L, Lu, J, Muzny, D, Nagaswamy, U, Reid, J, Sabo, A, Yu, J, Guo, X, Li, Y, Wu, R, Marth, GT, Garrison, EP, Leong, WF, Ward, AN, Del Angel, G, Depristo, MA, Gabriel, SB, Gupta, N, Hartl, C, Poplin, RE, Clark, AG, Rodriguez-Flores, JL, Flicek, P, Clarke, L, Smith, RE, Zheng-Bradley, X, Macarthur, DG, Bustamante, CD, Gravel, S, Craig, DW, Christoforides, A, Homer, N, Izatt, T, Sherry, ST, Xiao, C, Dermitzakis, E, Abecasis, GR, Kang, HM, McVean, GA, Mardis, ER, Dooling, D, Fulton, L, Fulton, R, Koboldt, DC, Durbin, RM, Balasubramaniam, S, Keane, TM, McCarthy, S, Stalker, J, Gerstein, MB, Balasubramanian, S, Habegger, L, Garrison, EP, Gibbs, RA, Bainbridge, M, Muzny, D, Yu, F, Yu, J, Del Angel, G, Handsaker, RE, Makarov, V, Rodriguez-Flores, JL, Jin, H, Kim, W, Kim, KC, Flicek, P, Beal, K, Clarke, L, Cunningham, F, Herrero, J, McLaren, WM, Ritchie, GR, Zheng-Bradley, X, Tabrizi, S, Macarthur, DG, Lek, M, Bustamante, CD, De La Vega, FM, Craig, DW, Kurdoglu, AA, Lappalainen, T, Rosenfeld, JA, Michelson, LP, Awadalla, P, Hodgkinson, A, McVean, GA, Chen, K, Tyler-Smith, C, Chen, Y, Colonna, V, Frankish, A, Harrow, J, Xue, Y, Gerstein, MB, Abyzov, A, Balasubramanian, S, Chen, J, Clarke, D, Fu, Y, Harmanci, AO, Jin, M, Khurana, E, Mu, XJ, Sisu, C, Gibbs, RA, Kovar, C, Kalra, D, Hale, W, Fowler, G, Muzny, D, Reid, J, Wang, J, Guo, X, Li, G, Li, Y, Zheng, X, Altshuler, DM, Flicek, P, Clarke, L, Barker, J, Kelman, G, Kulesha, E, Leinonen, R, McLaren, WM, Radhakrishnan, R, Roa, A, Smirnov, D, Smith, RE, Streeter, I, Toneva, I, Vaughan, B, Zheng-Bradley, X, Bentley, DR, Cox, T, Humphray, S, Kahn, S, Sudbrak, R, Albrecht, MW, Lienhard, M, Craig, DW, Izatt, T, Kurdoglu, AA, Sherry, ST, Ananiev, V, Belaia, Z, Beloslyudtsev, D, Bouk, N, Chen, C, Church, D, Cohen, R, Cook, C, Garner, J, Hefferon, T, Kimelman, M, Liu, C, Lopez, J, Meric, P, O'sullivan, C, Ostapchuk, Y, Ponomarov, S, Schneider, V, Shekhtman, E, Sirotkin, K, Slotta, D, Xiao, C, Zhang, H, Haussler, D, Abecasis, GR, McVean, GA, Alkan, C, Ko, A, Dooling, D, Durbin, RM, Balasubramaniam, S, Keane, TM, McCarthy, S, Stalker, J, Chakravarti, A, Abecasis, GR, Barnes, KC, Beiswanger, C, Burchard, E, Bustamante, CD, Cai, H, Cao, H, Durbin, RM, Gharani, N, Gibbs, RA, Gignoux, CR, Gravel, S, Henn, B, Jones, D, Jorde, L, Kaye, JS, Keinan, A, Kent, A, Kerasidou, A, Li, Y, Mathias, R, McVean, G, Moreno-Estrada, A, Ossorio, PN, Parker, M, Reich, D, Rotimi, CN, Royal, CD, Sandoval, K, Su, Y, Sudbrak, R, Tian, Z, Timmermann, B, Tishkoff, S, Toji, LH, Tyler-Smith, C, Via, M, Wang, Y, Yang, H, Yang, L, Zhu, J, Bodmer, W, Bedoya, G, Ruiz-Linares, A, Ming, CZ, Yang, G, You, CJ, Peltonen, L, Garcia-Montero, A, Orfao, A, Dutil, J, Martinez-Cruzado, JC, Oleksyk, TK, Brooks, LD, Felsenfeld, AL, McEwen, JE, Clemm, NC, Duncanson, A, Dunn, M, Green, ED, Guyer, MS & Peterson, JL 2014, 'Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences', Genome Biology, vol. 15, no. 6, R88. https://doi.org/10.1186/gb-2014-15-6-r88
Colonna, V. ; Ayub, Q. ; Chen, Y. ; Pagani, L. ; Luisi, P. ; Pybus, M. ; Garrison, E. ; Xue, Y. ; Tyler-Smith, C. ; Abecasis, G. R. ; Auton, A. ; Brooks, L. D. ; Depristo, M. A. ; Durbin, R. M. ; Handsaker, R. E. ; Kang, H. M. ; Marth, G. T. ; McVean, Ga ; Altshuler, D. M. ; Durbin, R. M. ; Abecasis, G. R. ; Bentley, D. R. ; Chakravarti, A. ; Clark, A. G. ; Donnelly, P. ; Eichler, E. E. ; Flicek, P. ; Gabriel, S. B. ; Gibbs, R. A. ; Green, E. D. ; Hurles, M. E. ; Knoppers, B. M. ; Korbel, J. O. ; Lander, E. S. ; Lee, C. ; Lehrach, H. ; Mardis, E. R. ; Marth, G. T. ; McVean, G. A. ; Nickerson, D. A. ; Schmidt, J. P. ; Sherry, S. T. ; Wang, J. ; Wilson, R. K. ; Gibbs, R. A. ; Dinh, H. ; Kovar, C. ; Lee, S. ; Lewis, L. ; Muzny, D. ; Reid, J. ; Wang, M. ; Wang, J. ; Fang, X. ; Guo, X. ; Jian, M. ; Jiang, H. ; Jin, X. ; Li, G. ; Li, J. ; Li, Y. ; Li, Z. ; Liu, X. ; Lu, Y. ; Ma, X. ; Su, Z. ; Tai, S. ; Tang, M. ; Wang, B. ; Wang, G. ; Wu, H. ; Wu, R. ; Yin, Y. ; Zhang, W. ; Zhao, J. ; Zhao, M. ; Zheng, X. ; Zhou, Y. ; Lander, E. S. ; Altshuler, D. M. ; Gabriel, S. B. ; Gupta, N. ; Flicek, P. ; Clarke, L. ; Leinonen, R. ; Smith, R. E. ; Zheng-Bradley, X. ; Bentley, D. R. ; Grocock, R. ; Humphray, S. ; James, T. ; Kingsbury, Z. ; Lehrach, H. ; Sudbrak, R. ; Albrecht, M. W. ; Amstislavskiy, V. S. ; Borodina, T. A. ; Lienhard, M. ; Mertes, F. ; Sultan, M. ; Timmermann, B. ; Yaspo, M. L. ; Sherry, S. T. ; McVean, G. A. ; Mardis, E. R. ; Wilson, R. K. ; Fulton, L. ; Fulton, R. ; Weinstock, G. M. ; Durbin, R. M. ; Balasubramaniam, S. ; Burton, J. ; Danecek, P. ; Keane, T. M. ; Kolb-Kokocinski, A. ; McCarthy, S. ; Stalker, J. ; Quail, M. ; Schmidt, J. P. ; Davies, C. J. ; Gollub, J. ; Webster, T. ; Wong, B. ; Zhan, Y. ; Auton, A. ; Gibbs, R. A. ; Yu, F. ; Bainbridge, M. ; Challis, D. ; Evani, U. S. ; Lu, J. ; Muzny, D. ; Nagaswamy, U. ; Reid, J. ; Sabo, A. ; Wang, Y. ; Yu, J. ; Wang, J. ; Coin, L. J. ; Fang, L. ; Guo, X. ; Jin, X. ; Li, G. ; Li, Q. ; Li, Y. ; Li, Z. ; Lin, H. ; Liu, B. ; Luo, R. ; Qin, N. ; Shao, H. ; Wang, B. ; Xie, Y. ; Ye, C. ; Yu, C. ; Zhang, F. ; Zheng, H. ; Zhu, H. ; Marth, G. T. ; Garrison, E. P. ; Kural, D. ; Lee, W. P. ; Leong, W. F. ; Ward, A. N. ; Wu, J. ; Zhang, M. ; Lee, C. ; Griffin, L. ; Hsieh, C. H. ; Mills, R. E. ; Shi, X. ; von Grotthuss, M. ; Zhang, C. ; Daly, M. J. ; Depristo, M. A. ; Altshuler, D. M. ; Banks, E. ; Bhatia, G. ; Carneiro, M. O. ; Del Angel, G. ; Gabriel, S. B. ; Genovese, G. ; Gupta, N. ; Handsaker, R. E. ; Hartl, C. ; Lander, E. S. ; McCarroll, S. A. ; Nemesh, J. C. ; Poplin, R. E. ; Schaffner, S. F. ; Shakir, K. ; Yoon, S. C. ; Lihm, J. ; Makarov, V. ; Jin, H. ; Kim, W. ; Kim, K. C. ; Korbel, J. O. ; Rausch, T. ; Flicek, P. ; Beal, K. ; Clarke, L. ; Cunningham, F. ; Herrero, J. ; McLaren, W. M. ; Ritchie, G. R. ; Smith, R. E. ; Zheng-Bradley, X. ; Clark, A. G. ; Gottipati, S. ; Keinan, A. ; Rodriguez-Flores, J. L. ; Sabeti, P. C. ; Grossman, S. R. ; Tabrizi, S. ; Tariyal, R. ; Cooper, D. N. ; Ball, E. V. ; Stenson, P. D. ; Bentley, D. R. ; Barnes, B. ; Bauer, M. ; Cheetham, R. ; Cox, T. ; Eberle, M. ; Humphray, S. ; Kahn, S. ; Murray, L. ; Peden, J. ; Shaw, R. ; Ye, K. ; Batzer, M. A. ; Konkel, M. K. ; Walker, J. A. ; Macarthur, D. G. ; Lek, M. ; Sudbrak, R. ; Amstislavskiy, V. S. ; Herwig, R. ; Shriver, M. D. ; Bustamante, C. D. ; Byrnes, J. K. ; De La Vega, F. M. ; Gravel, S. ; Kenny, E. E. ; Kidd, J. M. ; Lacroute, P. ; Maples, B. K. ; Moreno-Estrada, A. ; Zakharia, F. ; Halperin, E. ; Baran, Y. ; Craig, D. W. ; Christoforides, A. ; Homer, N. ; Izatt, T. ; Kurdoglu, A. A. ; Sinari, S. A. ; Squire, K. ; Sherry, S. T. ; Xiao, C. ; Sebat, J. ; Bafna, V. ; Ye, K. ; Burchard, E. G. ; Hernandez, R. D. ; Gignoux, C. R. ; Haussler, D. ; Hormozdiari, Fereydoun ; Kent, W. J. ; Howie, B. ; Ruiz-Linares, A. ; Dermitzakis, E. T. ; Lappalainen, T. ; Devine, S. E. ; Liu, X. ; Maroo, A. ; Tallon, L. J. ; Rosenfeld, J. A. ; Michelson, L. P. ; Anderson, P. ; Angius, A. ; Bigham, A. ; Blackwell, T. ; Busonero, F. ; Cucca, Francesco ; Fuchsberger, C. ; Jones, C. ; Li, Y. ; Lyons, R. ; Maschio, A. ; Porcu, E. ; Reinier, F. ; Sanna, S. ; Schlessinger, D. ; Sidore, C. ; Tan, A. ; Trost, M. K. ; Awadalla, P. ; Hodgkinson, A. ; Lunter, G. ; McVean, G. A. ; Marchini, J. L. ; Myers, S. ; Churchhouse, C. ; Delaneau, O. ; Gupta-Hinch, A. ; Iqbal, Z. ; Mathieson, I. ; Rimmer, A. ; Xifara, D. K. ; Oleksyk, T. K. ; Fu, Y. ; Liu, X. ; Xiong, M. ; Jorde, L. ; Witherspoon, D. ; Xing, J. ; Browning, B. L. ; Alkan, C. ; Hajirasouliha, I. ; Hormozdiari, F. ; Ko, A. ; Sudmant, P. H. ; Mardis, E. R. ; Chen, K. ; Chinwalla, A. ; Ding, L. ; Dooling, D. ; Koboldt, D. C. ; McLellan, M. D. ; Wallis, J. W. ; Wendl, M. C. ; Zhang, Q. ; Durbin, R. M. ; Hurles, M. E. ; Tyler-Smith, C. ; Albers, C. A. ; Ayub, Q. ; Balasubramaniam, S. ; Chen, Y. ; Coffey, A. J. ; Colonna, V. ; Danecek, P. ; Huang, N. ; Jostins, L. ; Keane, T. M. ; Li, H. ; McCarthy, S. ; Scally, A. ; Stalker, J. ; Walter, K. ; Xue, Y. ; Zhang, Y. ; Gerstein, M. B. ; Abyzov, A. ; Balasubramanian, S. ; Chen, J. ; Clarke, D. ; Fu, Y. ; Habegger, L. ; Harmanci, A. O. ; Jin, M. ; Khurana, E. ; Mu, X. J. ; Sisu, C. ; Li, Y. ; Luo, R. ; Zhu, H. ; Lee, C. ; Griffin, L. ; Hsieh, C. H. ; Mills, R. E. ; Shi, X. ; von Grotthuss, M. ; Zhang, C. ; Marth, G. T. ; Garrison, E. P. ; Kural, D. ; Lee, W. P. ; Ward, A. N. ; Wu, J. ; Zhang, M. ; McCarroll, S. A. ; Altshuler, D. M. ; Banks, E. ; Del Angel, G. ; Genovese, G. ; Handsaker, R. E. ; Hartl, C. ; Nemesh, J. C. ; Shakir, K. ; Yoon, S. C. ; Lihm, J. ; Makarov, V. ; Degenhardt, J. ; Flicek, P. ; Clarke, L. ; Smith, R. E. ; Zheng-Bradley, X. ; Korbel, J. O. ; Rausch, T. ; Stütz, A. M. ; Bentley, D. R. ; Barnes, B. ; Cheetham, R. ; Eberle, M. ; Humphray, S. ; Kahn, S. ; Murray, L. ; Shaw, R. ; Ye, K. ; Batzer, M. A. ; Konkel, M. K. ; Walker, J. A. ; Lacroute, P. ; Craig, D. W. ; Homer, N. ; Church, D. ; Xiao, C. ; Sebat, J. ; Bafna, V. ; Michaelson, J. J. ; Ye, K. ; Devine, S. E. ; Liu, X. ; Maroo, A. ; Tallon, L. J. ; Lunter, G. ; McVean, G. A. ; Iqbal, Z. ; Witherspoon, D. ; Xing, J. ; Eichler, E. E. ; Alkan, C. ; Hajirasouliha, I. ; Hormozdiari, F. ; Ko, A. ; Sudmant, P. H. ; Chen, K. ; Chinwalla, A. ; Ding, L. ; McLellan, M. D. ; Wallis, J. W. ; Hurles, M. E. ; Blackburne, B. ; Li, H. ; Lindsay, S. J. ; Ning, Z. ; Scally, A. ; Walter, K. ; Zhang, Y. ; Gerstein, M. B. ; Abyzov, A. ; Chen, J. ; Clarke, D. ; Khurana, E. ; Mu, X. J. ; Sisu, C. ; Gibbs, R. A. ; Yu, F. ; Bainbridge, M. ; Challis, D. ; Evani, U. S. ; Kovar, C. ; Lewis, L. ; Lu, J. ; Muzny, D. ; Nagaswamy, U. ; Reid, J. ; Sabo, A. ; Yu, J. ; Guo, X. ; Li, Y. ; Wu, R. ; Marth, G. T. ; Garrison, E. P. ; Leong, W. F. ; Ward, A. N. ; Del Angel, G. ; Depristo, M. A. ; Gabriel, S. B. ; Gupta, N. ; Hartl, C. ; Poplin, R. E. ; Clark, A. G. ; Rodriguez-Flores, J. L. ; Flicek, P. ; Clarke, L. ; Smith, R. E. ; Zheng-Bradley, X. ; Macarthur, D. G. ; Bustamante, C. D. ; Gravel, S. ; Craig, D. W. ; Christoforides, A. ; Homer, N. ; Izatt, T. ; Sherry, S. T. ; Xiao, C. ; Dermitzakis, E. ; Abecasis, G. R. ; Kang, H. M. ; McVean, G. A. ; Mardis, E. R. ; Dooling, D. ; Fulton, L. ; Fulton, R. ; Koboldt, D. C. ; Durbin, R. M. ; Balasubramaniam, S. ; Keane, T. M. ; McCarthy, S. ; Stalker, J. ; Gerstein, M. B. ; Balasubramanian, S. ; Habegger, L. ; Garrison, E. P. ; Gibbs, R. A. ; Bainbridge, M. ; Muzny, D. ; Yu, F. ; Yu, J. ; Del Angel, G. ; Handsaker, R. E. ; Makarov, V. ; Rodriguez-Flores, J. L. ; Jin, H. ; Kim, W. ; Kim, K. C. ; Flicek, P. ; Beal, K. ; Clarke, L. ; Cunningham, F. ; Herrero, J. ; McLaren, W. M. ; Ritchie, G. R. ; Zheng-Bradley, X. ; Tabrizi, S. ; Macarthur, D. G. ; Lek, M. ; Bustamante, C. D. ; De La Vega, F. M. ; Craig, D. W. ; Kurdoglu, A. A. ; Lappalainen, T. ; Rosenfeld, J. A. ; Michelson, L. P. ; Awadalla, P. ; Hodgkinson, A. ; McVean, G. A. ; Chen, K. ; Tyler-Smith, C. ; Chen, Y. ; Colonna, V. ; Frankish, A. ; Harrow, J. ; Xue, Y. ; Gerstein, M. B. ; Abyzov, A. ; Balasubramanian, S. ; Chen, J. ; Clarke, D. ; Fu, Y. ; Harmanci, A. O. ; Jin, M. ; Khurana, E. ; Mu, X. J. ; Sisu, C. ; Gibbs, R. A. ; Kovar, C. ; Kalra, D. ; Hale, W. ; Fowler, G. ; Muzny, D. ; Reid, J. ; Wang, J. ; Guo, X. ; Li, G. ; Li, Y. ; Zheng, X. ; Altshuler, D. M. ; Flicek, P. ; Clarke, L. ; Barker, J. ; Kelman, G. ; Kulesha, E. ; Leinonen, R. ; McLaren, W. M. ; Radhakrishnan, R. ; Roa, A. ; Smirnov, D. ; Smith, R. E. ; Streeter, I. ; Toneva, I. ; Vaughan, B. ; Zheng-Bradley, X. ; Bentley, D. R. ; Cox, T. ; Humphray, S. ; Kahn, S. ; Sudbrak, R. ; Albrecht, M. W. ; Lienhard, M. ; Craig, D. W. ; Izatt, T. ; Kurdoglu, A. A. ; Sherry, S. T. ; Ananiev, V. ; Belaia, Z. ; Beloslyudtsev, D. ; Bouk, N. ; Chen, C. ; Church, D. ; Cohen, R. ; Cook, C. ; Garner, J. ; Hefferon, T. ; Kimelman, M. ; Liu, C. ; Lopez, J. ; Meric, P. ; O'sullivan, C. ; Ostapchuk, Y. ; Ponomarov, S. ; Schneider, V. ; Shekhtman, E. ; Sirotkin, K. ; Slotta, D. ; Xiao, C. ; Zhang, H. ; Haussler, D. ; Abecasis, G. R. ; McVean, G. A. ; Alkan, C. ; Ko, A. ; Dooling, D. ; Durbin, R. M. ; Balasubramaniam, S. ; Keane, T. M. ; McCarthy, S. ; Stalker, J. ; Chakravarti, A. ; Abecasis, G. R. ; Barnes, K. C. ; Beiswanger, C. ; Burchard, E. ; Bustamante, C. D. ; Cai, H. ; Cao, H. ; Durbin, R. M. ; Gharani, N. ; Gibbs, R. A. ; Gignoux, C. R. ; Gravel, S. ; Henn, B. ; Jones, D. ; Jorde, L. ; Kaye, J. S. ; Keinan, A. ; Kent, A. ; Kerasidou, A. ; Li, Y. ; Mathias, R. ; McVean, G. ; Moreno-Estrada, A. ; Ossorio, P. N. ; Parker, M. ; Reich, D. ; Rotimi, C. N. ; Royal, C. D. ; Sandoval, K. ; Su, Y. ; Sudbrak, R. ; Tian, Z. ; Timmermann, B. ; Tishkoff, S. ; Toji, L. H. ; Tyler-Smith, C. ; Via, M. ; Wang, Y. ; Yang, H. ; Yang, L. ; Zhu, J. ; Bodmer, W. ; Bedoya, G. ; Ruiz-Linares, A. ; Ming, C. Z. ; Yang, G. ; You, C. J. ; Peltonen, L. ; Garcia-Montero, A. ; Orfao, A. ; Dutil, J. ; Martinez-Cruzado, J. C. ; Oleksyk, T. K. ; Brooks, L. D. ; Felsenfeld, A. L. ; McEwen, J. E. ; Clemm, N. C. ; Duncanson, A. ; Dunn, M. ; Green, E. D. ; Guyer, M. S. ; Peterson, J. L. / Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences. In: Genome Biology. 2014 ; Vol. 15, No. 6.
@article{c4d9f3f0ce7f46ad89894610c3dc8280,
title = "Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences",
abstract = "Background: Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we extend this dataset to include additional variants, survey sites with low levels of differentiation, and evaluate the extent to which highly differentiated sites are likely to result from selective or other processes. Results: We demonstrate that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high population differentiation are enriched for positive selection events and that one half may be the result of classic selective sweeps. Among these, we rediscover known examples, where we actually identify the established functional SNP, and discover novel examples including the genes ABCA12, CALD1 and ZNF804, which we speculate may be linked to adaptations in skin, calcium metabolism and defense, respectively. Conclusions: We identify known and many novel candidate regions for geographically restricted positive selection, and suggest several directions for further research.",
author = "V. Colonna and Q. Ayub and Y. Chen and L. Pagani and P. Luisi and M. Pybus and E. Garrison and Y. Xue and C. Tyler-Smith and Abecasis, {G. R.} and A. Auton and Brooks, {L. D.} and Depristo, {M. A.} and Durbin, {R. M.} and Handsaker, {R. E.} and Kang, {H. M.} and Marth, {G. T.} and Ga McVean and Altshuler, {D. M.} and Durbin, {R. M.} and Abecasis, {G. R.} and Bentley, {D. R.} and A. Chakravarti and Clark, {A. G.} and P. Donnelly and Eichler, {E. E.} and P. Flicek and Gabriel, {S. B.} and Gibbs, {R. A.} and Green, {E. D.} and Hurles, {M. E.} and Knoppers, {B. M.} and Korbel, {J. O.} and Lander, {E. S.} and C. Lee and H. Lehrach and Mardis, {E. R.} and Marth, {G. T.} and McVean, {G. A.} and Nickerson, {D. A.} and Schmidt, {J. P.} and Sherry, {S. T.} and J. Wang and Wilson, {R. K.} and Gibbs, {R. A.} and H. Dinh and C. Kovar and S. Lee and L. Lewis and D. Muzny and J. Reid and M. Wang and J. Wang and X. Fang and X. Guo and M. Jian and H. Jiang and X. Jin and G. Li and J. Li and Y. Li and Z. Li and X. Liu and Y. Lu and X. Ma and Z. Su and S. Tai and M. Tang and B. Wang and G. Wang and H. Wu and R. Wu and Y. Yin and W. Zhang and J. Zhao and M. Zhao and X. Zheng and Y. Zhou and Lander, {E. S.} and Altshuler, {D. M.} and Gabriel, {S. B.} and N. Gupta and P. Flicek and L. Clarke and R. Leinonen and Smith, {R. E.} and X. Zheng-Bradley and Bentley, {D. R.} and R. Grocock and S. Humphray and T. James and Z. Kingsbury and H. Lehrach and R. Sudbrak and Albrecht, {M. W.} and Amstislavskiy, {V. S.} and Borodina, {T. A.} and M. Lienhard and F. Mertes and M. Sultan and B. Timmermann and Yaspo, {M. L.} and Sherry, {S. T.} and McVean, {G. A.} and Mardis, {E. R.} and Wilson, {R. K.} and L. Fulton and R. Fulton and Weinstock, {G. M.} and Durbin, {R. M.} and S. Balasubramaniam and J. Burton and P. Danecek and Keane, {T. M.} and A. Kolb-Kokocinski and S. McCarthy and J. Stalker and M. Quail and Schmidt, {J. P.} and Davies, {C. J.} and J. Gollub and T. Webster and B. Wong and Y. Zhan and A. Auton and Gibbs, {R. A.} and F. Yu and M. Bainbridge and D. Challis and Evani, {U. S.} and J. Lu and D. Muzny and U. Nagaswamy and J. Reid and A. Sabo and Y. Wang and J. Yu and J. Wang and Coin, {L. J.} and L. Fang and X. Guo and X. Jin and G. Li and Q. Li and Y. Li and Z. Li and H. Lin and B. Liu and R. Luo and N. Qin and H. Shao and B. Wang and Y. Xie and C. Ye and C. Yu and F. Zhang and H. Zheng and H. Zhu and Marth, {G. T.} and Garrison, {E. P.} and D. Kural and Lee, {W. P.} and Leong, {W. F.} and Ward, {A. N.} and J. Wu and M. Zhang and C. Lee and L. Griffin and Hsieh, {C. H.} and Mills, {R. E.} and X. Shi and {von Grotthuss}, M. and C. Zhang and Daly, {M. J.} and Depristo, {M. A.} and Altshuler, {D. M.} and E. Banks and G. Bhatia and Carneiro, {M. O.} and {Del Angel}, G. and Gabriel, {S. B.} and G. Genovese and N. Gupta and Handsaker, {R. E.} and C. Hartl and Lander, {E. S.} and McCarroll, {S. A.} and Nemesh, {J. C.} and Poplin, {R. E.} and Schaffner, {S. F.} and K. Shakir and Yoon, {S. C.} and J. Lihm and V. Makarov and H. Jin and W. Kim and Kim, {K. C.} and Korbel, {J. O.} and T. Rausch and P. Flicek and K. Beal and L. Clarke and F. Cunningham and J. Herrero and McLaren, {W. M.} and Ritchie, {G. R.} and Smith, {R. E.} and X. Zheng-Bradley and Clark, {A. G.} and S. Gottipati and A. Keinan and Rodriguez-Flores, {J. L.} and Sabeti, {P. C.} and Grossman, {S. R.} and S. Tabrizi and R. Tariyal and Cooper, {D. N.} and Ball, {E. V.} and Stenson, {P. D.} and Bentley, {D. R.} and B. Barnes and M. Bauer and R. Cheetham and T. Cox and M. Eberle and S. Humphray and S. Kahn and L. Murray and J. Peden and R. Shaw and K. Ye and Batzer, {M. A.} and Konkel, {M. K.} and Walker, {J. A.} and Macarthur, {D. G.} and M. Lek and R. Sudbrak and Amstislavskiy, {V. S.} and R. Herwig and Shriver, {M. D.} and Bustamante, {C. D.} and Byrnes, {J. K.} and {De La Vega}, {F. M.} and S. Gravel and Kenny, {E. E.} and Kidd, {J. M.} and P. Lacroute and Maples, {B. K.} and A. Moreno-Estrada and F. Zakharia and E. Halperin and Y. Baran and Craig, {D. W.} and A. Christoforides and N. Homer and T. Izatt and Kurdoglu, {A. A.} and Sinari, {S. A.} and K. Squire and Sherry, {S. T.} and C. Xiao and J. Sebat and V. Bafna and K. Ye and Burchard, {E. G.} and Hernandez, {R. D.} and Gignoux, {C. R.} and D. Haussler and Fereydoun Hormozdiari and Kent, {W. J.} and B. Howie and A. Ruiz-Linares and Dermitzakis, {E. T.} and T. Lappalainen and Devine, {S. E.} and X. Liu and A. Maroo and Tallon, {L. J.} and Rosenfeld, {J. A.} and Michelson, {L. P.} and P. Anderson and A. Angius and A. Bigham and T. Blackwell and F. Busonero and Francesco Cucca and C. Fuchsberger and C. Jones and Y. Li and R. Lyons and A. Maschio and E. Porcu and F. Reinier and S. Sanna and D. Schlessinger and C. Sidore and A. Tan and Trost, {M. K.} and P. Awadalla and A. Hodgkinson and G. Lunter and McVean, {G. A.} and Marchini, {J. L.} and S. Myers and C. Churchhouse and O. Delaneau and A. Gupta-Hinch and Z. Iqbal and I. Mathieson and A. Rimmer and Xifara, {D. K.} and Oleksyk, {T. K.} and Y. Fu and X. Liu and M. Xiong and L. Jorde and D. Witherspoon and J. Xing and Browning, {B. L.} and C. Alkan and I. Hajirasouliha and F. Hormozdiari and A. Ko and Sudmant, {P. H.} and Mardis, {E. R.} and K. Chen and A. Chinwalla and L. Ding and D. Dooling and Koboldt, {D. C.} and McLellan, {M. D.} and Wallis, {J. W.} and Wendl, {M. C.} and Q. Zhang and Durbin, {R. M.} and Hurles, {M. E.} and C. Tyler-Smith and Albers, {C. A.} and Q. Ayub and S. Balasubramaniam and Y. Chen and Coffey, {A. J.} and V. Colonna and P. Danecek and N. Huang and L. Jostins and Keane, {T. M.} and H. Li and S. McCarthy and A. Scally and J. Stalker and K. Walter and Y. Xue and Y. Zhang and Gerstein, {M. B.} and A. Abyzov and S. Balasubramanian and J. Chen and D. Clarke and Y. Fu and L. Habegger and Harmanci, {A. O.} and M. Jin and E. Khurana and Mu, {X. J.} and C. Sisu and Y. Li and R. Luo and H. Zhu and C. Lee and L. Griffin and Hsieh, {C. H.} and Mills, {R. E.} and X. Shi and {von Grotthuss}, M. and C. Zhang and Marth, {G. T.} and Garrison, {E. P.} and D. Kural and Lee, {W. P.} and Ward, {A. N.} and J. Wu and M. Zhang and McCarroll, {S. A.} and Altshuler, {D. M.} and E. Banks and {Del Angel}, G. and G. Genovese and Handsaker, {R. E.} and C. Hartl and Nemesh, {J. C.} and K. Shakir and Yoon, {S. C.} and J. Lihm and V. Makarov and J. Degenhardt and P. Flicek and L. Clarke and Smith, {R. E.} and X. Zheng-Bradley and Korbel, {J. O.} and T. Rausch and St{\"u}tz, {A. M.} and Bentley, {D. R.} and B. Barnes and R. Cheetham and M. Eberle and S. Humphray and S. Kahn and L. Murray and R. Shaw and K. Ye and Batzer, {M. A.} and Konkel, {M. K.} and Walker, {J. A.} and P. Lacroute and Craig, {D. W.} and N. Homer and D. Church and C. Xiao and J. Sebat and V. Bafna and Michaelson, {J. J.} and K. Ye and Devine, {S. E.} and X. Liu and A. Maroo and Tallon, {L. J.} and G. Lunter and McVean, {G. A.} and Z. Iqbal and D. Witherspoon and J. Xing and Eichler, {E. E.} and C. Alkan and I. Hajirasouliha and F. Hormozdiari and A. Ko and Sudmant, {P. H.} and K. Chen and A. Chinwalla and L. Ding and McLellan, {M. D.} and Wallis, {J. W.} and Hurles, {M. E.} and B. Blackburne and H. Li and Lindsay, {S. J.} and Z. Ning and A. Scally and K. Walter and Y. Zhang and Gerstein, {M. B.} and A. Abyzov and J. Chen and D. Clarke and E. Khurana and Mu, {X. J.} and C. Sisu and Gibbs, {R. A.} and F. Yu and M. Bainbridge and D. Challis and Evani, {U. S.} and C. Kovar and L. Lewis and J. Lu and D. Muzny and U. Nagaswamy and J. Reid and A. Sabo and J. Yu and X. Guo and Y. Li and R. Wu and Marth, {G. T.} and Garrison, {E. P.} and Leong, {W. F.} and Ward, {A. N.} and {Del Angel}, G. and Depristo, {M. A.} and Gabriel, {S. B.} and N. Gupta and C. Hartl and Poplin, {R. E.} and Clark, {A. G.} and Rodriguez-Flores, {J. L.} and P. Flicek and L. Clarke and Smith, {R. E.} and X. Zheng-Bradley and Macarthur, {D. G.} and Bustamante, {C. D.} and S. Gravel and Craig, {D. W.} and A. Christoforides and N. Homer and T. Izatt and Sherry, {S. T.} and C. Xiao and E. Dermitzakis and Abecasis, {G. R.} and Kang, {H. M.} and McVean, {G. A.} and Mardis, {E. R.} and D. Dooling and L. Fulton and R. Fulton and Koboldt, {D. C.} and Durbin, {R. M.} and S. Balasubramaniam and Keane, {T. M.} and S. McCarthy and J. Stalker and Gerstein, {M. B.} and S. Balasubramanian and L. Habegger and Garrison, {E. P.} and Gibbs, {R. A.} and M. Bainbridge and D. Muzny and F. Yu and J. Yu and {Del Angel}, G. and Handsaker, {R. E.} and V. Makarov and Rodriguez-Flores, {J. L.} and H. Jin and W. Kim and Kim, {K. C.} and P. Flicek and K. Beal and L. Clarke and F. Cunningham and J. Herrero and McLaren, {W. M.} and Ritchie, {G. R.} and X. Zheng-Bradley and S. Tabrizi and Macarthur, {D. G.} and M. Lek and Bustamante, {C. D.} and {De La Vega}, {F. M.} and Craig, {D. W.} and Kurdoglu, {A. A.} and T. Lappalainen and Rosenfeld, {J. A.} and Michelson, {L. P.} and P. Awadalla and A. Hodgkinson and McVean, {G. A.} and K. Chen and C. Tyler-Smith and Y. Chen and V. Colonna and A. Frankish and J. Harrow and Y. Xue and Gerstein, {M. B.} and A. Abyzov and S. Balasubramanian and J. Chen and D. Clarke and Y. Fu and Harmanci, {A. O.} and M. Jin and E. Khurana and Mu, {X. J.} and C. Sisu and Gibbs, {R. A.} and C. Kovar and D. Kalra and W. Hale and G. Fowler and D. Muzny and J. Reid and J. Wang and X. Guo and G. Li and Y. Li and X. Zheng and Altshuler, {D. M.} and P. Flicek and L. Clarke and J. Barker and G. Kelman and E. Kulesha and R. Leinonen and McLaren, {W. M.} and R. Radhakrishnan and A. Roa and D. Smirnov and Smith, {R. E.} and I. Streeter and I. Toneva and B. Vaughan and X. Zheng-Bradley and Bentley, {D. R.} and T. Cox and S. Humphray and S. Kahn and R. Sudbrak and Albrecht, {M. W.} and M. Lienhard and Craig, {D. W.} and T. Izatt and Kurdoglu, {A. A.} and Sherry, {S. T.} and V. Ananiev and Z. Belaia and D. Beloslyudtsev and N. Bouk and C. Chen and D. Church and R. Cohen and C. Cook and J. Garner and T. Hefferon and M. Kimelman and C. Liu and J. Lopez and P. Meric and C. O'sullivan and Y. Ostapchuk and S. Ponomarov and V. Schneider and E. Shekhtman and K. Sirotkin and D. Slotta and C. Xiao and H. Zhang and D. Haussler and Abecasis, {G. R.} and McVean, {G. A.} and C. Alkan and A. Ko and D. Dooling and Durbin, {R. M.} and S. Balasubramaniam and Keane, {T. M.} and S. McCarthy and J. Stalker and A. Chakravarti and Abecasis, {G. R.} and Barnes, {K. C.} and C. Beiswanger and E. Burchard and Bustamante, {C. D.} and H. Cai and H. Cao and Durbin, {R. M.} and N. Gharani and Gibbs, {R. A.} and Gignoux, {C. R.} and S. Gravel and B. Henn and D. Jones and L. Jorde and Kaye, {J. S.} and A. Keinan and A. Kent and A. Kerasidou and Y. Li and R. Mathias and G. McVean and A. Moreno-Estrada and Ossorio, {P. N.} and M. Parker and D. Reich and Rotimi, {C. N.} and Royal, {C. D.} and K. Sandoval and Y. Su and R. Sudbrak and Z. Tian and B. Timmermann and S. Tishkoff and Toji, {L. H.} and C. Tyler-Smith and M. Via and Y. Wang and H. Yang and L. Yang and J. Zhu and W. Bodmer and G. Bedoya and A. Ruiz-Linares and Ming, {C. Z.} and G. Yang and You, {C. J.} and L. Peltonen and A. Garcia-Montero and A. Orfao and J. Dutil and Martinez-Cruzado, {J. C.} and Oleksyk, {T. K.} and Brooks, {L. D.} and Felsenfeld, {A. L.} and McEwen, {J. E.} and Clemm, {N. C.} and A. Duncanson and M. Dunn and Green, {E. D.} and Guyer, {M. S.} and Peterson, {J. L.}",
year = "2014",
month = "6",
day = "30",
doi = "10.1186/gb-2014-15-6-r88",
language = "English (US)",
volume = "15",
journal = "Genome Biology",
issn = "1465-6914",
publisher = "BioMed Central",
number = "6",

}

TY - JOUR

T1 - Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences

AU - Colonna, V.

AU - Ayub, Q.

AU - Chen, Y.

AU - Pagani, L.

AU - Luisi, P.

AU - Pybus, M.

AU - Garrison, E.

AU - Xue, Y.

AU - Tyler-Smith, C.

AU - Abecasis, G. R.

AU - Auton, A.

AU - Brooks, L. D.

AU - Depristo, M. A.

AU - Durbin, R. M.

AU - Handsaker, R. E.

AU - Kang, H. M.

AU - Marth, G. T.

AU - McVean, Ga

AU - Altshuler, D. M.

AU - Durbin, R. M.

AU - Abecasis, G. R.

AU - Bentley, D. R.

AU - Chakravarti, A.

AU - Clark, A. G.

AU - Donnelly, P.

AU - Eichler, E. E.

AU - Flicek, P.

AU - Gabriel, S. B.

AU - Gibbs, R. A.

AU - Green, E. D.

AU - Hurles, M. E.

AU - Knoppers, B. M.

AU - Korbel, J. O.

AU - Lander, E. S.

AU - Lee, C.

AU - Lehrach, H.

AU - Mardis, E. R.

AU - Marth, G. T.

AU - McVean, G. A.

AU - Nickerson, D. A.

AU - Schmidt, J. P.

AU - Sherry, S. T.

AU - Wang, J.

AU - Wilson, R. K.

AU - Gibbs, R. A.

AU - Dinh, H.

AU - Kovar, C.

AU - Lee, S.

AU - Lewis, L.

AU - Muzny, D.

AU - Reid, J.

AU - Wang, M.

AU - Wang, J.

AU - Fang, X.

AU - Guo, X.

AU - Jian, M.

AU - Jiang, H.

AU - Jin, X.

AU - Li, G.

AU - Li, J.

AU - Li, Y.

AU - Li, Z.

AU - Liu, X.

AU - Lu, Y.

AU - Ma, X.

AU - Su, Z.

AU - Tai, S.

AU - Tang, M.

AU - Wang, B.

AU - Wang, G.

AU - Wu, H.

AU - Wu, R.

AU - Yin, Y.

AU - Zhang, W.

AU - Zhao, J.

AU - Zhao, M.

AU - Zheng, X.

AU - Zhou, Y.

AU - Lander, E. S.

AU - Altshuler, D. M.

AU - Gabriel, S. B.

AU - Gupta, N.

AU - Flicek, P.

AU - Clarke, L.

AU - Leinonen, R.

AU - Smith, R. E.

AU - Zheng-Bradley, X.

AU - Bentley, D. R.

AU - Grocock, R.

AU - Humphray, S.

AU - James, T.

AU - Kingsbury, Z.

AU - Lehrach, H.

AU - Sudbrak, R.

AU - Albrecht, M. W.

AU - Amstislavskiy, V. S.

AU - Borodina, T. A.

AU - Lienhard, M.

AU - Mertes, F.

AU - Sultan, M.

AU - Timmermann, B.

AU - Yaspo, M. L.

AU - Sherry, S. T.

AU - McVean, G. A.

AU - Mardis, E. R.

AU - Wilson, R. K.

AU - Fulton, L.

AU - Fulton, R.

AU - Weinstock, G. M.

AU - Durbin, R. M.

AU - Balasubramaniam, S.

AU - Burton, J.

AU - Danecek, P.

AU - Keane, T. M.

AU - Kolb-Kokocinski, A.

AU - McCarthy, S.

AU - Stalker, J.

AU - Quail, M.

AU - Schmidt, J. P.

AU - Davies, C. J.

AU - Gollub, J.

AU - Webster, T.

AU - Wong, B.

AU - Zhan, Y.

AU - Auton, A.

AU - Gibbs, R. A.

AU - Yu, F.

AU - Bainbridge, M.

AU - Challis, D.

AU - Evani, U. S.

AU - Lu, J.

AU - Muzny, D.

AU - Nagaswamy, U.

AU - Reid, J.

AU - Sabo, A.

AU - Wang, Y.

AU - Yu, J.

AU - Wang, J.

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AU - Fang, L.

AU - Guo, X.

AU - Jin, X.

AU - Li, G.

AU - Li, Q.

AU - Li, Y.

AU - Li, Z.

AU - Lin, H.

AU - Liu, B.

AU - Luo, R.

AU - Qin, N.

AU - Shao, H.

AU - Wang, B.

AU - Xie, Y.

AU - Ye, C.

AU - Yu, C.

AU - Zhang, F.

AU - Zheng, H.

AU - Zhu, H.

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AU - Garrison, E. P.

AU - Kural, D.

AU - Lee, W. P.

AU - Leong, W. F.

AU - Ward, A. N.

AU - Wu, J.

AU - Zhang, M.

AU - Lee, C.

AU - Griffin, L.

AU - Hsieh, C. H.

AU - Mills, R. E.

AU - Shi, X.

AU - von Grotthuss, M.

AU - Zhang, C.

AU - Daly, M. J.

AU - Depristo, M. A.

AU - Altshuler, D. M.

AU - Banks, E.

AU - Bhatia, G.

AU - Carneiro, M. O.

AU - Del Angel, G.

AU - Gabriel, S. B.

AU - Genovese, G.

AU - Gupta, N.

AU - Handsaker, R. E.

AU - Hartl, C.

AU - Lander, E. S.

AU - McCarroll, S. A.

AU - Nemesh, J. C.

AU - Poplin, R. E.

AU - Schaffner, S. F.

AU - Shakir, K.

AU - Yoon, S. C.

AU - Lihm, J.

AU - Makarov, V.

AU - Jin, H.

AU - Kim, W.

AU - Kim, K. C.

AU - Korbel, J. O.

AU - Rausch, T.

AU - Flicek, P.

AU - Beal, K.

AU - Clarke, L.

AU - Cunningham, F.

AU - Herrero, J.

AU - McLaren, W. M.

AU - Ritchie, G. R.

AU - Smith, R. E.

AU - Zheng-Bradley, X.

AU - Clark, A. G.

AU - Gottipati, S.

AU - Keinan, A.

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AU - Sabeti, P. C.

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AU - Barnes, B.

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AU - Eberle, M.

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AU - Kahn, S.

AU - Murray, L.

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AU - Shaw, R.

AU - Ye, K.

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AU - Konkel, M. K.

AU - Walker, J. A.

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AU - Lek, M.

AU - Sudbrak, R.

AU - Amstislavskiy, V. S.

AU - Herwig, R.

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AU - Bustamante, C. D.

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AU - Lacroute, P.

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AU - Moreno-Estrada, A.

AU - Zakharia, F.

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AU - Craig, D. W.

AU - Christoforides, A.

AU - Homer, N.

AU - Izatt, T.

AU - Kurdoglu, A. A.

AU - Sinari, S. A.

AU - Squire, K.

AU - Sherry, S. T.

AU - Xiao, C.

AU - Sebat, J.

AU - Bafna, V.

AU - Ye, K.

AU - Burchard, E. G.

AU - Hernandez, R. D.

AU - Gignoux, C. R.

AU - Haussler, D.

AU - Hormozdiari, Fereydoun

AU - Kent, W. J.

AU - Howie, B.

AU - Ruiz-Linares, A.

AU - Dermitzakis, E. T.

AU - Lappalainen, T.

AU - Devine, S. E.

AU - Liu, X.

AU - Maroo, A.

AU - Tallon, L. J.

AU - Rosenfeld, J. A.

AU - Michelson, L. P.

AU - Anderson, P.

AU - Angius, A.

AU - Bigham, A.

AU - Blackwell, T.

AU - Busonero, F.

AU - Cucca, Francesco

AU - Fuchsberger, C.

AU - Jones, C.

AU - Li, Y.

AU - Lyons, R.

AU - Maschio, A.

AU - Porcu, E.

AU - Reinier, F.

AU - Sanna, S.

AU - Schlessinger, D.

AU - Sidore, C.

AU - Tan, A.

AU - Trost, M. K.

AU - Awadalla, P.

AU - Hodgkinson, A.

AU - Lunter, G.

AU - McVean, G. A.

AU - Marchini, J. L.

AU - Myers, S.

AU - Churchhouse, C.

AU - Delaneau, O.

AU - Gupta-Hinch, A.

AU - Iqbal, Z.

AU - Mathieson, I.

AU - Rimmer, A.

AU - Xifara, D. K.

AU - Oleksyk, T. K.

AU - Fu, Y.

AU - Liu, X.

AU - Xiong, M.

AU - Jorde, L.

AU - Witherspoon, D.

AU - Xing, J.

AU - Browning, B. L.

AU - Alkan, C.

AU - Hajirasouliha, I.

AU - Hormozdiari, F.

AU - Ko, A.

AU - Sudmant, P. H.

AU - Mardis, E. R.

AU - Chen, K.

AU - Chinwalla, A.

AU - Ding, L.

AU - Dooling, D.

AU - Koboldt, D. C.

AU - McLellan, M. D.

AU - Wallis, J. W.

AU - Wendl, M. C.

AU - Zhang, Q.

AU - Durbin, R. M.

AU - Hurles, M. E.

AU - Tyler-Smith, C.

AU - Albers, C. A.

AU - Ayub, Q.

AU - Balasubramaniam, S.

AU - Chen, Y.

AU - Coffey, A. J.

AU - Colonna, V.

AU - Danecek, P.

AU - Huang, N.

AU - Jostins, L.

AU - Keane, T. M.

AU - Li, H.

AU - McCarthy, S.

AU - Scally, A.

AU - Stalker, J.

AU - Walter, K.

AU - Xue, Y.

AU - Zhang, Y.

AU - Gerstein, M. B.

AU - Abyzov, A.

AU - Balasubramanian, S.

AU - Chen, J.

AU - Clarke, D.

AU - Fu, Y.

AU - Habegger, L.

AU - Harmanci, A. O.

AU - Jin, M.

AU - Khurana, E.

AU - Mu, X. J.

AU - Sisu, C.

AU - Li, Y.

AU - Luo, R.

AU - Zhu, H.

AU - Lee, C.

AU - Griffin, L.

AU - Hsieh, C. H.

AU - Mills, R. E.

AU - Shi, X.

AU - von Grotthuss, M.

AU - Zhang, C.

AU - Marth, G. T.

AU - Garrison, E. P.

AU - Kural, D.

AU - Lee, W. P.

AU - Ward, A. N.

AU - Wu, J.

AU - Zhang, M.

AU - McCarroll, S. A.

AU - Altshuler, D. M.

AU - Banks, E.

AU - Del Angel, G.

AU - Genovese, G.

AU - Handsaker, R. E.

AU - Hartl, C.

AU - Nemesh, J. C.

AU - Shakir, K.

AU - Yoon, S. C.

AU - Lihm, J.

AU - Makarov, V.

AU - Degenhardt, J.

AU - Flicek, P.

AU - Clarke, L.

AU - Smith, R. E.

AU - Zheng-Bradley, X.

AU - Korbel, J. O.

AU - Rausch, T.

AU - Stütz, A. M.

AU - Bentley, D. R.

AU - Barnes, B.

AU - Cheetham, R.

AU - Eberle, M.

AU - Humphray, S.

AU - Kahn, S.

AU - Murray, L.

AU - Shaw, R.

AU - Ye, K.

AU - Batzer, M. A.

AU - Konkel, M. K.

AU - Walker, J. A.

AU - Lacroute, P.

AU - Craig, D. W.

AU - Homer, N.

AU - Church, D.

AU - Xiao, C.

AU - Sebat, J.

AU - Bafna, V.

AU - Michaelson, J. J.

AU - Ye, K.

AU - Devine, S. E.

AU - Liu, X.

AU - Maroo, A.

AU - Tallon, L. J.

AU - Lunter, G.

AU - McVean, G. A.

AU - Iqbal, Z.

AU - Witherspoon, D.

AU - Xing, J.

AU - Eichler, E. E.

AU - Alkan, C.

AU - Hajirasouliha, I.

AU - Hormozdiari, F.

AU - Ko, A.

AU - Sudmant, P. H.

AU - Chen, K.

AU - Chinwalla, A.

AU - Ding, L.

AU - McLellan, M. D.

AU - Wallis, J. W.

AU - Hurles, M. E.

AU - Blackburne, B.

AU - Li, H.

AU - Lindsay, S. J.

AU - Ning, Z.

AU - Scally, A.

AU - Walter, K.

AU - Zhang, Y.

AU - Gerstein, M. B.

AU - Abyzov, A.

AU - Chen, J.

AU - Clarke, D.

AU - Khurana, E.

AU - Mu, X. J.

AU - Sisu, C.

AU - Gibbs, R. A.

AU - Yu, F.

AU - Bainbridge, M.

AU - Challis, D.

AU - Evani, U. S.

AU - Kovar, C.

AU - Lewis, L.

AU - Lu, J.

AU - Muzny, D.

AU - Nagaswamy, U.

AU - Reid, J.

AU - Sabo, A.

AU - Yu, J.

AU - Guo, X.

AU - Li, Y.

AU - Wu, R.

AU - Marth, G. T.

AU - Garrison, E. P.

AU - Leong, W. F.

AU - Ward, A. N.

AU - Del Angel, G.

AU - Depristo, M. A.

AU - Gabriel, S. B.

AU - Gupta, N.

AU - Hartl, C.

AU - Poplin, R. E.

AU - Clark, A. G.

AU - Rodriguez-Flores, J. L.

AU - Flicek, P.

AU - Clarke, L.

AU - Smith, R. E.

AU - Zheng-Bradley, X.

AU - Macarthur, D. G.

AU - Bustamante, C. D.

AU - Gravel, S.

AU - Craig, D. W.

AU - Christoforides, A.

AU - Homer, N.

AU - Izatt, T.

AU - Sherry, S. T.

AU - Xiao, C.

AU - Dermitzakis, E.

AU - Abecasis, G. R.

AU - Kang, H. M.

AU - McVean, G. A.

AU - Mardis, E. R.

AU - Dooling, D.

AU - Fulton, L.

AU - Fulton, R.

AU - Koboldt, D. C.

AU - Durbin, R. M.

AU - Balasubramaniam, S.

AU - Keane, T. M.

AU - McCarthy, S.

AU - Stalker, J.

AU - Gerstein, M. B.

AU - Balasubramanian, S.

AU - Habegger, L.

AU - Garrison, E. P.

AU - Gibbs, R. A.

AU - Bainbridge, M.

AU - Muzny, D.

AU - Yu, F.

AU - Yu, J.

AU - Del Angel, G.

AU - Handsaker, R. E.

AU - Makarov, V.

AU - Rodriguez-Flores, J. L.

AU - Jin, H.

AU - Kim, W.

AU - Kim, K. C.

AU - Flicek, P.

AU - Beal, K.

AU - Clarke, L.

AU - Cunningham, F.

AU - Herrero, J.

AU - McLaren, W. M.

AU - Ritchie, G. R.

AU - Zheng-Bradley, X.

AU - Tabrizi, S.

AU - Macarthur, D. G.

AU - Lek, M.

AU - Bustamante, C. D.

AU - De La Vega, F. M.

AU - Craig, D. W.

AU - Kurdoglu, A. A.

AU - Lappalainen, T.

AU - Rosenfeld, J. A.

AU - Michelson, L. P.

AU - Awadalla, P.

AU - Hodgkinson, A.

AU - McVean, G. A.

AU - Chen, K.

AU - Tyler-Smith, C.

AU - Chen, Y.

AU - Colonna, V.

AU - Frankish, A.

AU - Harrow, J.

AU - Xue, Y.

AU - Gerstein, M. B.

AU - Abyzov, A.

AU - Balasubramanian, S.

AU - Chen, J.

AU - Clarke, D.

AU - Fu, Y.

AU - Harmanci, A. O.

AU - Jin, M.

AU - Khurana, E.

AU - Mu, X. J.

AU - Sisu, C.

AU - Gibbs, R. A.

AU - Kovar, C.

AU - Kalra, D.

AU - Hale, W.

AU - Fowler, G.

AU - Muzny, D.

AU - Reid, J.

AU - Wang, J.

AU - Guo, X.

AU - Li, G.

AU - Li, Y.

AU - Zheng, X.

AU - Altshuler, D. M.

AU - Flicek, P.

AU - Clarke, L.

AU - Barker, J.

AU - Kelman, G.

AU - Kulesha, E.

AU - Leinonen, R.

AU - McLaren, W. M.

AU - Radhakrishnan, R.

AU - Roa, A.

AU - Smirnov, D.

AU - Smith, R. E.

AU - Streeter, I.

AU - Toneva, I.

AU - Vaughan, B.

AU - Zheng-Bradley, X.

AU - Bentley, D. R.

AU - Cox, T.

AU - Humphray, S.

AU - Kahn, S.

AU - Sudbrak, R.

AU - Albrecht, M. W.

AU - Lienhard, M.

AU - Craig, D. W.

AU - Izatt, T.

AU - Kurdoglu, A. A.

AU - Sherry, S. T.

AU - Ananiev, V.

AU - Belaia, Z.

AU - Beloslyudtsev, D.

AU - Bouk, N.

AU - Chen, C.

AU - Church, D.

AU - Cohen, R.

AU - Cook, C.

AU - Garner, J.

AU - Hefferon, T.

AU - Kimelman, M.

AU - Liu, C.

AU - Lopez, J.

AU - Meric, P.

AU - O'sullivan, C.

AU - Ostapchuk, Y.

AU - Ponomarov, S.

AU - Schneider, V.

AU - Shekhtman, E.

AU - Sirotkin, K.

AU - Slotta, D.

AU - Xiao, C.

AU - Zhang, H.

AU - Haussler, D.

AU - Abecasis, G. R.

AU - McVean, G. A.

AU - Alkan, C.

AU - Ko, A.

AU - Dooling, D.

AU - Durbin, R. M.

AU - Balasubramaniam, S.

AU - Keane, T. M.

AU - McCarthy, S.

AU - Stalker, J.

AU - Chakravarti, A.

AU - Abecasis, G. R.

AU - Barnes, K. C.

AU - Beiswanger, C.

AU - Burchard, E.

AU - Bustamante, C. D.

AU - Cai, H.

AU - Cao, H.

AU - Durbin, R. M.

AU - Gharani, N.

AU - Gibbs, R. A.

AU - Gignoux, C. R.

AU - Gravel, S.

AU - Henn, B.

AU - Jones, D.

AU - Jorde, L.

AU - Kaye, J. S.

AU - Keinan, A.

AU - Kent, A.

AU - Kerasidou, A.

AU - Li, Y.

AU - Mathias, R.

AU - McVean, G.

AU - Moreno-Estrada, A.

AU - Ossorio, P. N.

AU - Parker, M.

AU - Reich, D.

AU - Rotimi, C. N.

AU - Royal, C. D.

AU - Sandoval, K.

AU - Su, Y.

AU - Sudbrak, R.

AU - Tian, Z.

AU - Timmermann, B.

AU - Tishkoff, S.

AU - Toji, L. H.

AU - Tyler-Smith, C.

AU - Via, M.

AU - Wang, Y.

AU - Yang, H.

AU - Yang, L.

AU - Zhu, J.

AU - Bodmer, W.

AU - Bedoya, G.

AU - Ruiz-Linares, A.

AU - Ming, C. Z.

AU - Yang, G.

AU - You, C. J.

AU - Peltonen, L.

AU - Garcia-Montero, A.

AU - Orfao, A.

AU - Dutil, J.

AU - Martinez-Cruzado, J. C.

AU - Oleksyk, T. K.

AU - Brooks, L. D.

AU - Felsenfeld, A. L.

AU - McEwen, J. E.

AU - Clemm, N. C.

AU - Duncanson, A.

AU - Dunn, M.

AU - Green, E. D.

AU - Guyer, M. S.

AU - Peterson, J. L.

PY - 2014/6/30

Y1 - 2014/6/30

N2 - Background: Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we extend this dataset to include additional variants, survey sites with low levels of differentiation, and evaluate the extent to which highly differentiated sites are likely to result from selective or other processes. Results: We demonstrate that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high population differentiation are enriched for positive selection events and that one half may be the result of classic selective sweeps. Among these, we rediscover known examples, where we actually identify the established functional SNP, and discover novel examples including the genes ABCA12, CALD1 and ZNF804, which we speculate may be linked to adaptations in skin, calcium metabolism and defense, respectively. Conclusions: We identify known and many novel candidate regions for geographically restricted positive selection, and suggest several directions for further research.

AB - Background: Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we extend this dataset to include additional variants, survey sites with low levels of differentiation, and evaluate the extent to which highly differentiated sites are likely to result from selective or other processes. Results: We demonstrate that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high population differentiation are enriched for positive selection events and that one half may be the result of classic selective sweeps. Among these, we rediscover known examples, where we actually identify the established functional SNP, and discover novel examples including the genes ABCA12, CALD1 and ZNF804, which we speculate may be linked to adaptations in skin, calcium metabolism and defense, respectively. Conclusions: We identify known and many novel candidate regions for geographically restricted positive selection, and suggest several directions for further research.

UR - http://www.scopus.com/inward/record.url?scp=84912072340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84912072340&partnerID=8YFLogxK

U2 - 10.1186/gb-2014-15-6-r88

DO - 10.1186/gb-2014-15-6-r88

M3 - Article

C2 - 24980144

AN - SCOPUS:84912072340

VL - 15

JO - Genome Biology

JF - Genome Biology

SN - 1465-6914

IS - 6

M1 - R88

ER -