Human genetic determinants of dengue virus susceptibility

Lark L Schneider, Eva Mertens, Anne Claire Brehin, Maria Dolores Fernandez-Garcia, Ali Amara, Philippe Després, Anavaj Sakuntabhai

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Dengue virus (DENV) is an emerging mosquito-borne pathogen that produces significant morbidity worldwide resulting in an estimated 50-100 million infections annually. DENV causes a spectrum of illness ranging from inapparent infection to life-threatening hemorrhagic fever and shock. The varied DENV disease outcome is determined by complex interactions between immunopathologic, viral, and human genetic factors. This review summarizes these interactions with a focus on human genetic determinants of DENV susceptibility, including human leukocyte antigens, blood type, and single nucleotide polymorphisms in immune response genes that have been associated with DENV disease. We also discuss other factors related to DENV outcome including viral genetic determinants, age, ethnicity, and nutritional status as they relate to DENV susceptibility. We emphasize the need for functional genetics studies to complement association-based data and we call for controlled study designs and standard clinical DENV disease definitions that will strengthen conclusions based on human genetic DENV studies.

Original languageEnglish (US)
Pages (from-to)143-156
Number of pages14
JournalMicrobes and Infection
Volume11
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • Arbovirus
  • Dengue hemorrhagic fever
  • Dengue virus
  • Human genetic susceptibility
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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