Human gene name normalization using text matching with automatically extracted synonym dictionaries

Haw Ren Fang, Kevin Murphy, Yang Jin, Jessica Signoff, Peter S. White

Research output: Contribution to conferencePaper

25 Scopus citations

Abstract

The identification of genes in biomedical text typically consists of two stages: identifying gene mentions and normalization of gene names. We have created an automated process that takes the output of named entity recognition (NER) systems designed to identify genes and normalizes them to standard referents. The system identifies human gene synonyms from online databases to generate an extensive synonym lexicon. The lexicon is then compared to a list of candidate gene mentions using various string transformations that can be applied and chained in a flexible order, followed by exact string matching or approximate string matching. Using a gold standard of MEDLINE abstracts manually tagged and normalized for mentions of human genes, a combined tagging and normalization system achieved 0.669 F-measure (0.718 precision and 0.626 recall) at the mention level, and 0.901 F-measure (0.957 precision and 0.857 recall) at the document level for documents used for tagger training.

Original languageEnglish (US)
Pages41-48
Number of pages8
StatePublished - Jan 1 2006
Externally publishedYes
EventHLT-NAACL 2006 Workshop on Linking Natural Language Processing and Biology: Towards Deeper Biological Literature Analysis, BioNLP 2006 - New York, United States
Duration: Jun 8 2006 → …

Conference

ConferenceHLT-NAACL 2006 Workshop on Linking Natural Language Processing and Biology: Towards Deeper Biological Literature Analysis, BioNLP 2006
CountryUnited States
CityNew York
Period6/8/06 → …

ASJC Scopus subject areas

  • Language and Linguistics
  • Information Systems
  • Software
  • Health Informatics
  • Computer Science Applications
  • Biomedical Engineering

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  • Cite this

    Fang, H. R., Murphy, K., Jin, Y., Signoff, J., & White, P. S. (2006). Human gene name normalization using text matching with automatically extracted synonym dictionaries. 41-48. Paper presented at HLT-NAACL 2006 Workshop on Linking Natural Language Processing and Biology: Towards Deeper Biological Literature Analysis, BioNLP 2006, New York, United States.