Abstract
Background: 43 S preinitiation complex (PIC) formation is an important step for eukaryotic translation initiation.
Results: A thermodynamic framework of human 43 S PIC reveals a complicated network of positive and negative cooperativity among the components.
Conclusion: eIF2 and eIF3 play essential roles in stabilizing the 43 S PIC.
Significance: Quantitative analysis of initiation complex formation leads to understanding of mechanistic details in translation initiation.
Original language | English (US) |
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Pages (from-to) | 31827-31836 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 46 |
DOIs | |
State | Published - Nov 14 2014 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
- Medicine(all)