Background: 43 S preinitiation complex (PIC) formation is an important step for eukaryotic translation initiation.
Results: A thermodynamic framework of human 43 S PIC reveals a complicated network of positive and negative cooperativity among the components.
Conclusion: eIF2 and eIF3 play essential roles in stabilizing the 43 S PIC.
Significance: Quantitative analysis of initiation complex formation leads to understanding of mechanistic details in translation initiation.
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology