Human embryonic stem cells for brain repair?

Su Chun Zhang, Xue Jun Li, Michael Johnson, Matthew T. Pankratz

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Cell therapy has been perceived as the main or ultimate goal of human embryonic stem (ES) cell research. Where are we now and how are we going to get there? There has been rapid success in devising in vitro protocols for differentiating human ES cells to neuroepithelial cells. Progress has also been made to guide these neural precursors further to more specialized neural cells such as spinal motor neurons and dopamine-producing neurons. However, some of the in vitro produced neuronal types such as dopamine neurons do not possess all the phenotypes of their in vivo counterparts, which may contribute to the limited success of these cells in repairing injured or diseased brain and spinal cord in animal models. Hence, efficient generation of neural subtypes with correct phenotypes remains a challenge, although major hurdles still lie ahead in applying the human ES cell-derived neural cells clinically. We propose that careful studies on neural differentiation from human ES cells may provide more immediate answers to clinically relevant problems, such as drug discovery, mechanisms of disease and stimulation of endogenous stem cells.

Original languageEnglish (US)
Pages (from-to)87-99
Number of pages13
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume363
Issue number1489
DOIs
StatePublished - Jan 12 2008
Externally publishedYes

Keywords

  • Cell therapy
  • Embryonic stem cells
  • Neural patterning
  • Neural transplantation
  • Neuroectoderm

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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