Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs

Lisa J. Scherer; John Douglas Mcpherson; John J. Wasmuth; J. Lawrence Marsh

doi:10.1016/0888-7543(92)90275-W

Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs

Lisa J. Scherer, John Douglas Mcpherson, John J. Wasmuth, J. Lawrence Marsh

Biochemistry and Molecular Medicine

Research output: Contribution to journal › Article

29 Scopus citations

Abstract

We have cloned full-length DDC cDNAs from a human hepatoma cDNA library [DDC; dopa decarboxylase; aromatic-L-amino acid decarboxylase, EC 4.1.1.28]. The protein encoded by hepatoma cells is the same as that encoded by adrenal chromaffin derived pheochromocytoma cells, despite reported differences in biochemical properties. We have confirmed the location of the DDC gene to chromosome 7 using a new panel of somatic cell hybrids, and we have localized the gene to band p11 on chromosome 7 by fluorescent in situ hybridization. The human gene retains 65% amino acid identity with Drosophila DDC (Accession No. X04426) and considerable structural similarity with other enzymes (F.R. Jackson, 1990, J. Mol. Evol. 31: 325-329, and references therein).

Original language	English (US)
Pages (from-to)	469-471
Number of pages	3
Journal	Genomics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(92)90275-W
State	Published - 1992

ASJC Scopus subject areas

Genetics

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Scherer, L. J., Mcpherson, J. D., Wasmuth, J. J., & Marsh, J. L. (1992). Human dopa decarboxylase: Localization to human chromosome 7p11 and characterization of hepatic cDNAs. Genomics, 13(2), 469-471. https://doi.org/10.1016/0888-7543(92)90275-W

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abstract = "We have cloned full-length DDC cDNAs from a human hepatoma cDNA library [DDC; dopa decarboxylase; aromatic-L-amino acid decarboxylase, EC 4.1.1.28]. The protein encoded by hepatoma cells is the same as that encoded by adrenal chromaffin derived pheochromocytoma cells, despite reported differences in biochemical properties. We have confirmed the location of the DDC gene to chromosome 7 using a new panel of somatic cell hybrids, and we have localized the gene to band p11 on chromosome 7 by fluorescent in situ hybridization. The human gene retains 65% amino acid identity with Drosophila DDC (Accession No. X04426) and considerable structural similarity with other enzymes (F.R. Jackson, 1990, J. Mol. Evol. 31: 325-329, and references therein).",

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