Human cytomegalovirus infections in patients with HIV

M. Onorato, Richard B Pollard

Research output: Contribution to journalArticlepeer-review


HCMV is an important pathogen in late-stage HIV infection not only because of the variety of clinical syndromes it causes but also because of the potential interactions between HIV and HCMV as co-pathogens. While some clinical syndromes, such as retinitis, oesophageal ulcers and colitis, are fairly well characterized, others, such as the neurological syndromes associated with HCMV, are not. Efforts are underway to improve diagnostic methods for these less well-established syndromes; polymerase chain reaction assays and more sophisticated neuro-imaging studies are potential tools. Better diagnostic approaches will be critical to any evaluation of therapeutic agents, especially for the neurological syndromes. New approaches for treatment of both newly diagnosed and recurrent disease are being investigated, particularly for HCMV retinitis. Preservation of vision and quality of life will be the major considerations in evaluating new therapies.

Original languageEnglish (US)
Pages (from-to)345-355
Number of pages11
JournalBailliere's Clinical Infectious Diseases
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)


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