Human corpus callosum in aging and alzheimer's disease: a magnetic resonance imaging study

A. Biegon, J. L. Eberling, B. C. Richardson, M. S. Roos, S. T S Wong, Bruce R Reed, W. J. Jagust

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


The involvement of the corpus callosum in aging and Alzheimer's disease (AD) is not clear. We measured cross sectional area of the entire corpus callosum (CC), as well as the front 20% (genu), middle 60% (body), and posterior 20% (splenium) of the structure from a midsagittal MRI slice in AD patients (N = 20), and young (N = 16) and old (N = 13) control subjects. We found that mean CC area in young controls was 570 ± 107 mm2. Aging did not significantly affect the mean area of the CC (562 ± 98 mm2). A small, s significant reduction was seen in AD in comparison to the young control group (480 ± 133 mm2). However, AD is accompanied by a large and statistically regnificant reduction in the genu area in comparison to both young and old control subjects. A trend toward an age-dependent reduction in the body area is also accentuated in AD patients who showed significantly smaller callosal bodies than young controls. We conclude that selective changes within the corpus callosum accompany aging and AD pathology.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalNeurobiology of Aging
Issue number4
StatePublished - 1994


  • Aging
  • Alzheimer's disease
  • Corpus callosum
  • Human brain
  • Quantitative MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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