Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study

Lino R. Becerra, Hans C. Breiter, Milan Stojanovic, Scott M Fishman, Annabel Edwards, Alison R. Comite, R. Gilberto Gonzalez, David Borsook

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

Brain activity was studied with functional magnetic resonance imaging (fMRI) following thermal stimulation. Two groups (n = 6/group) of human male volunteers were given up to four noxious (46°C) and four non-noxious (41°C) stimuli. In the 46°C experiment, positive signal changes were found in the frontal gyri, anterior and posterior cingulate gyrus, thalamus, motor cortex, somatosensory cortex (SI and SII), supplementary motor area, insula, and cerebellum. Low-level negative signal changes appeared in the amygdala and hypothalamus. All regions activated by 46°C were also activated by 41°C. However, except for SI and thalamus, significantly more activation was observed for the 46°C stimulus. A significant attenuation of the signal change was observed by the third stimulus for the 46°C, but not for 41°C experiment. Similar findings were replicated in the second group. These fMRI findings specify differences between somatosensory and pain sensation and suggest a number of rich avenues for future research.

Original languageEnglish (US)
Pages (from-to)1044-1057
Number of pages14
JournalMagnetic Resonance in Medicine
Volume41
Issue number5
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Gyrus Cinguli
Motor Cortex
Thalamus
Hot Temperature
Magnetic Resonance Imaging
Somatosensory Cortex
Brain
Amygdala
Cerebellum
Hypothalamus
Volunteers
Pain

Keywords

  • fMRI
  • Heat
  • Pain
  • Peltier thermode

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Human brain activation under controlled thermal stimulation and habituation to noxious heat : An fMRI study. / Becerra, Lino R.; Breiter, Hans C.; Stojanovic, Milan; Fishman, Scott M; Edwards, Annabel; Comite, Alison R.; Gonzalez, R. Gilberto; Borsook, David.

In: Magnetic Resonance in Medicine, Vol. 41, No. 5, 1999, p. 1044-1057.

Research output: Contribution to journalArticle

Becerra, Lino R. ; Breiter, Hans C. ; Stojanovic, Milan ; Fishman, Scott M ; Edwards, Annabel ; Comite, Alison R. ; Gonzalez, R. Gilberto ; Borsook, David. / Human brain activation under controlled thermal stimulation and habituation to noxious heat : An fMRI study. In: Magnetic Resonance in Medicine. 1999 ; Vol. 41, No. 5. pp. 1044-1057.
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