Abstract
Specific rabbit antisera and over 100 human sera were found to precipitate iodinated mouse mammary tumor virus (MTV). The specificity of these reactions was tested in competitive inhibition studies. Three classes of reaction could be distinguished. The Class 1 reaction was the most specific; it could be inhibited only by MTV and was observed exclusively with rabbit anti-MTV. The Class 2 reaction was apparently against mouse cell determinants; it could be inhibited not only by MTV but also by mouse lactating mammary gland and was characteristic of rabbit anti-mouse lactating mammary gland. The Class 3 reaction was the least specific; it could be inhibited not only by MTV and mouse lactating mammary gland but also by dog milk. All of the human sera tested exhibited Class 3 reactivities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 765-768 |
| Number of pages | 4 |
| Journal | Cancer Research |
| Volume | 36 |
| State | Published - Jan 1 1976 |
Fingerprint
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Human Antibodies Binding to the Mouse Mammary Tumor Virus : A Nonspecific Reaction? / Newgard, Kent W.; Cardiff, Robert; Blair, Phyllis B.
In: Cancer Research, Vol. 36, 01.01.1976, p. 765-768.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human Antibodies Binding to the Mouse Mammary Tumor Virus
T2 - A Nonspecific Reaction?
AU - Newgard, Kent W.
AU - Cardiff, Robert
AU - Blair, Phyllis B.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - Specific rabbit antisera and over 100 human sera were found to precipitate iodinated mouse mammary tumor virus (MTV). The specificity of these reactions was tested in competitive inhibition studies. Three classes of reaction could be distinguished. The Class 1 reaction was the most specific; it could be inhibited only by MTV and was observed exclusively with rabbit anti-MTV. The Class 2 reaction was apparently against mouse cell determinants; it could be inhibited not only by MTV but also by mouse lactating mammary gland and was characteristic of rabbit anti-mouse lactating mammary gland. The Class 3 reaction was the least specific; it could be inhibited not only by MTV and mouse lactating mammary gland but also by dog milk. All of the human sera tested exhibited Class 3 reactivities.
AB - Specific rabbit antisera and over 100 human sera were found to precipitate iodinated mouse mammary tumor virus (MTV). The specificity of these reactions was tested in competitive inhibition studies. Three classes of reaction could be distinguished. The Class 1 reaction was the most specific; it could be inhibited only by MTV and was observed exclusively with rabbit anti-MTV. The Class 2 reaction was apparently against mouse cell determinants; it could be inhibited not only by MTV but also by mouse lactating mammary gland and was characteristic of rabbit anti-mouse lactating mammary gland. The Class 3 reaction was the least specific; it could be inhibited not only by MTV and mouse lactating mammary gland but also by dog milk. All of the human sera tested exhibited Class 3 reactivities.
UR - http://www.scopus.com/inward/record.url?scp=84965831728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965831728&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84965831728
VL - 36
SP - 765
EP - 768
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
ER -