HPV 6-associated HSIL/Squamous Carcinoma in the Anogenital Tract

Martina Z. Liu, Yin P. Hung, Eric C Huang, Brooke E. Howitt, Marisa R. Nucci, Christopher P. Crum

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections - 3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion - that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma. Two were associated with invasion one of which metastasized to a regional node. Two cases exhibited strong p53 positivity in the high-grade squamous intraepithelial lesion/squamous cell carcinoma component analogous to that seen in HPV-negative differentiated intraepithelial lesions of the external genitalia. This series of cases adds to the literature on low risk HPV-associated cervical squamous carcinomas. It underscores the similarities between the baseline cyto-morphology and benign mimics (low-grade squamous intraepithelial lesions), the subtle cytologic and immunohistochemical (MIB1) features heralding biologic aggressiveness, and in some potential pathways (p53) not usually involved in HPV-related anogenital neoplasia.

Original languageEnglish (US)
JournalInternational Journal of Gynecological Pathology
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Human papillomavirus 6
Squamous Cell Carcinoma
Genitalia
Papillomavirus Infections
Cellular Structures
Squamous Intraepithelial Lesions of the Cervix
Phenotype
Neoplasms

Keywords

  • Condyloma
  • HPV 6
  • HSIL
  • Squamous carcinoma
  • TP53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

HPV 6-associated HSIL/Squamous Carcinoma in the Anogenital Tract. / Liu, Martina Z.; Hung, Yin P.; Huang, Eric C; Howitt, Brooke E.; Nucci, Marisa R.; Crum, Christopher P.

In: International Journal of Gynecological Pathology, 01.01.2018.

Research output: Contribution to journalArticle

Liu, Martina Z. ; Hung, Yin P. ; Huang, Eric C ; Howitt, Brooke E. ; Nucci, Marisa R. ; Crum, Christopher P. / HPV 6-associated HSIL/Squamous Carcinoma in the Anogenital Tract. In: International Journal of Gynecological Pathology. 2018.
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