Abstract
Salmonella serotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of human Salmonella disease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects of Salmonella disease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research on Salmonella serotypes. This article reviews important milestones in the use of animal models to study human Salmonella disease and identify research needs to guide future work.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1806-1814 |
| Number of pages | 9 |
| Journal | Infection and Immunity |
| Volume | 79 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2011 |
Fingerprint
ASJC Scopus subject areas
- Immunology
- Microbiology
- Parasitology
- Infectious Diseases
Cite this
How to become a top model : Impact of animal experimentation on human Salmonella disease research. / Tsolis, Renee M; Xavier, Mariana N.; Santos, Renato L.; Baumler, Andreas J.
In: Infection and Immunity, Vol. 79, No. 5, 05.2011, p. 1806-1814.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How to become a top model
T2 - Impact of animal experimentation on human Salmonella disease research
AU - Tsolis, Renee M
AU - Xavier, Mariana N.
AU - Santos, Renato L.
AU - Baumler, Andreas J
PY - 2011/5
Y1 - 2011/5
N2 - Salmonella serotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of human Salmonella disease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects of Salmonella disease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research on Salmonella serotypes. This article reviews important milestones in the use of animal models to study human Salmonella disease and identify research needs to guide future work.
AB - Salmonella serotypes are a major cause of human morbidity and mortality worldwide. Over the past decades, a series of animal models have been developed to advance vaccine development, provide insights into immunity to infection, and study the pathogenesis of human Salmonella disease. The successive introduction of new animal models, each suited to interrogate previously neglected aspects of Salmonella disease, has ushered in important conceptual advances that continue to have a strong and sustained influence on the ideas driving research on Salmonella serotypes. This article reviews important milestones in the use of animal models to study human Salmonella disease and identify research needs to guide future work.
UR - http://www.scopus.com/inward/record.url?scp=79955593196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955593196&partnerID=8YFLogxK
U2 - 10.1128/IAI.01369-10
DO - 10.1128/IAI.01369-10
M3 - Article
C2 - 21343352
AN - SCOPUS:79955593196
VL - 79
SP - 1806
EP - 1814
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 5
ER -