Abstract
Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects. Malnourished children, the elderly, and pregnant or lactating females may be susceptible for Cu deficiency. Cu status and exposure in the population can currently not be easily measured, as neither plasma Cu nor plasma cuproenzymes reflect Cu status precisely. Some blood markers (such as ceruloplasmin) indicate severe Cu depletion, but do not inversely respond to Cu excess, and are not suitable to indicate marginal states. A biomarker of Cu is needed that is sensitive to small changes in Cu status, and that responds to Cu excess as well as deficiency. Such a marker will aid in monitoring Cu status in large populations, and will help to avoid chronic health effects (for example, liver damage in chronic toxicity, osteoporosis, loss of collagen stability, or increased susceptibility to infections in deficiency). The advent of high-throughput technologies has enabled us to screen for potential biomarkers in the whole proteome of a cell, not excluding markers that have no direct link to Cu. Further, this screening allows us to search for a whole group of proteins that, in combination, reflect Cu status. The present review emphasises the need to find sensitive biomarkers for Cu, examines potential markers of Cu status already available, and discusses methods to identify a novel suite of biomarkers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 676-683 |
| Number of pages | 8 |
| Journal | British Journal of Nutrition |
| Volume | 98 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2007 |
Fingerprint
Keywords
- Biomarkers
- Copper deficiency
- Copper excess
- Copper status
- Public health
ASJC Scopus subject areas
- Medicine (miscellaneous)
Cite this
How reliable and robust are current biomarkers for copper status? / Danzeisen, Ruth; Araya, Magdalena; Harrison, Brenda; Keen, Carl L; Solioz, Marc; Thiele, Dennis; Mcardle, Harry J.
In: British Journal of Nutrition, Vol. 98, No. 4, 10.2007, p. 676-683.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How reliable and robust are current biomarkers for copper status?
AU - Danzeisen, Ruth
AU - Araya, Magdalena
AU - Harrison, Brenda
AU - Keen, Carl L
AU - Solioz, Marc
AU - Thiele, Dennis
AU - Mcardle, Harry J.
PY - 2007/10
Y1 - 2007/10
N2 - Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects. Malnourished children, the elderly, and pregnant or lactating females may be susceptible for Cu deficiency. Cu status and exposure in the population can currently not be easily measured, as neither plasma Cu nor plasma cuproenzymes reflect Cu status precisely. Some blood markers (such as ceruloplasmin) indicate severe Cu depletion, but do not inversely respond to Cu excess, and are not suitable to indicate marginal states. A biomarker of Cu is needed that is sensitive to small changes in Cu status, and that responds to Cu excess as well as deficiency. Such a marker will aid in monitoring Cu status in large populations, and will help to avoid chronic health effects (for example, liver damage in chronic toxicity, osteoporosis, loss of collagen stability, or increased susceptibility to infections in deficiency). The advent of high-throughput technologies has enabled us to screen for potential biomarkers in the whole proteome of a cell, not excluding markers that have no direct link to Cu. Further, this screening allows us to search for a whole group of proteins that, in combination, reflect Cu status. The present review emphasises the need to find sensitive biomarkers for Cu, examines potential markers of Cu status already available, and discusses methods to identify a novel suite of biomarkers.
AB - Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects. Malnourished children, the elderly, and pregnant or lactating females may be susceptible for Cu deficiency. Cu status and exposure in the population can currently not be easily measured, as neither plasma Cu nor plasma cuproenzymes reflect Cu status precisely. Some blood markers (such as ceruloplasmin) indicate severe Cu depletion, but do not inversely respond to Cu excess, and are not suitable to indicate marginal states. A biomarker of Cu is needed that is sensitive to small changes in Cu status, and that responds to Cu excess as well as deficiency. Such a marker will aid in monitoring Cu status in large populations, and will help to avoid chronic health effects (for example, liver damage in chronic toxicity, osteoporosis, loss of collagen stability, or increased susceptibility to infections in deficiency). The advent of high-throughput technologies has enabled us to screen for potential biomarkers in the whole proteome of a cell, not excluding markers that have no direct link to Cu. Further, this screening allows us to search for a whole group of proteins that, in combination, reflect Cu status. The present review emphasises the need to find sensitive biomarkers for Cu, examines potential markers of Cu status already available, and discusses methods to identify a novel suite of biomarkers.
KW - Biomarkers
KW - Copper deficiency
KW - Copper excess
KW - Copper status
KW - Public health
UR - http://www.scopus.com/inward/record.url?scp=34748896029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34748896029&partnerID=8YFLogxK
U2 - 10.1017/S0007114507798951
DO - 10.1017/S0007114507798951
M3 - Article
C2 - 17666147
AN - SCOPUS:34748896029
VL - 98
SP - 676
EP - 683
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 4
ER -