How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test

Revi P. Mathew, Barbara D. Duffy, Wenli Wang, Benjamin R. Saville, Andrew A. Bremer

Research output: Contribution to journalArticlepeer-review

Abstract

The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10 % when the maximum cortisol concentration during an ITT was < 8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μ g CST is recommended for assessment of adrenal function.

Original languageEnglish (US)
Pages (from-to)733-739
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume25
Issue number7-8
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Adrenal deficiency
  • Adrenal sufficiency

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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