Abstract
The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10 % when the maximum cortisol concentration during an ITT was < 8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μ g CST is recommended for assessment of adrenal function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 733-739 |
| Number of pages | 7 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 25 |
| Issue number | 7-8 |
| DOIs | |
| State | Published - Aug 2012 |
| Externally published | Yes |
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Keywords
- Adrenal deficiency
- Adrenal sufficiency
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Pediatrics, Perinatology, and Child Health
Cite this
How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test. / Mathew, Revi P.; Duffy, Barbara D.; Wang, Wenli; Saville, Benjamin R.; Bremer, Andrew A.
In: Journal of Pediatric Endocrinology and Metabolism, Vol. 25, No. 7-8, 08.2012, p. 733-739.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test
AU - Mathew, Revi P.
AU - Duffy, Barbara D.
AU - Wang, Wenli
AU - Saville, Benjamin R.
AU - Bremer, Andrew A.
PY - 2012/8
Y1 - 2012/8
N2 - The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10 % when the maximum cortisol concentration during an ITT was < 8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μ g CST is recommended for assessment of adrenal function.
AB - The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10 % when the maximum cortisol concentration during an ITT was < 8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μ g CST is recommended for assessment of adrenal function.
KW - Adrenal deficiency
KW - Adrenal sufficiency
UR - http://www.scopus.com/inward/record.url?scp=84867751906&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867751906&partnerID=8YFLogxK
U2 - 10.1515/JPEM-201-0457
DO - 10.1515/JPEM-201-0457
M3 - Article
C2 - 23155702
AN - SCOPUS:84867751906
VL - 25
SP - 733
EP - 739
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
SN - 0334-018X
IS - 7-8
ER -