How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test

Revi P. Mathew; Barbara D. Duffy; Wenli Wang; Benjamin R. Saville; Andrew A. Bremer

doi:10.1515/JPEM-201-0457

How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test

Revi P. Mathew, Barbara D. Duffy, Wenli Wang, Benjamin R. Saville, Andrew A. Bremer

Research output: Contribution to journal › Article › peer-review

Abstract

The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10 % when the maximum cortisol concentration during an ITT was < 8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μ g CST is recommended for assessment of adrenal function.

Original language	English (US)
Pages (from-to)	733-739
Number of pages	7
Journal	Journal of Pediatric Endocrinology and Metabolism
Volume	25
Issue number	7-8
DOIs	https://doi.org/10.1515/JPEM-201-0457
State	Published - Aug 2012
Externally published	Yes

Keywords

Adrenal deficiency
Adrenal sufficiency

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Pediatrics, Perinatology, and Child Health

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abstract = "The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was < 10 % when the maximum cortisol concentration during an ITT was < 8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μ g CST is recommended for assessment of adrenal function.",

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AU - Saville, Benjamin R.

AU - Bremer, Andrew A.

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How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test

Abstract

Keywords

ASJC Scopus subject areas

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