Abstract
Although it is well known that the trabecular meshwork plays a central role in regulating the outflow of aqueous humor from the eye, the cellular mechanisms and events responsible for this function are poorly understood. In contrast, the mechanisms by which vascular endothelial cells modulate the permeability of blood vessels have been more thoroughly investigated. It is hypothesized that the cells of the TM employ mechanisms similar to those observed in the vascular endothelium to modulate aqueous humor permeability. Specifically, it is hypothesized that the cells of the TM employ Na-K-Cl cotransport to modulate their intracellular volume and thus the volume of the paracellular pathways through which aqueous humor may travel. The current knowledge about the role of Na-K-Cl cotransport and volume regulation in the regulation of vascular permeability, and evidence that similar physiologic events occur in the TM are reviewed. In addition, the implications for further study of aqueous humor outflow physiology are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 328-339 |
| Number of pages | 12 |
| Journal | Journal of Glaucoma |
| Volume | 8 |
| Issue number | 5 |
| State | Published - 1999 |
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Keywords
- Aqueous humor physiology
- Bumetanide
- Cell volume regulation
- Intraocular pressure
- Ion transport
- Na-K-Cl cotransport
- Trabecular meshwork
- Vascular endothelium
ASJC Scopus subject areas
- Ophthalmology
Cite this
How does the trabecular meshwork regulate outflow? Clues from the vascular endothelium. / Brandt, James D; O'Donnell, Martha E.
In: Journal of Glaucoma, Vol. 8, No. 5, 1999, p. 328-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - How does the trabecular meshwork regulate outflow? Clues from the vascular endothelium
AU - Brandt, James D
AU - O'Donnell, Martha E
PY - 1999
Y1 - 1999
N2 - Although it is well known that the trabecular meshwork plays a central role in regulating the outflow of aqueous humor from the eye, the cellular mechanisms and events responsible for this function are poorly understood. In contrast, the mechanisms by which vascular endothelial cells modulate the permeability of blood vessels have been more thoroughly investigated. It is hypothesized that the cells of the TM employ mechanisms similar to those observed in the vascular endothelium to modulate aqueous humor permeability. Specifically, it is hypothesized that the cells of the TM employ Na-K-Cl cotransport to modulate their intracellular volume and thus the volume of the paracellular pathways through which aqueous humor may travel. The current knowledge about the role of Na-K-Cl cotransport and volume regulation in the regulation of vascular permeability, and evidence that similar physiologic events occur in the TM are reviewed. In addition, the implications for further study of aqueous humor outflow physiology are discussed.
AB - Although it is well known that the trabecular meshwork plays a central role in regulating the outflow of aqueous humor from the eye, the cellular mechanisms and events responsible for this function are poorly understood. In contrast, the mechanisms by which vascular endothelial cells modulate the permeability of blood vessels have been more thoroughly investigated. It is hypothesized that the cells of the TM employ mechanisms similar to those observed in the vascular endothelium to modulate aqueous humor permeability. Specifically, it is hypothesized that the cells of the TM employ Na-K-Cl cotransport to modulate their intracellular volume and thus the volume of the paracellular pathways through which aqueous humor may travel. The current knowledge about the role of Na-K-Cl cotransport and volume regulation in the regulation of vascular permeability, and evidence that similar physiologic events occur in the TM are reviewed. In addition, the implications for further study of aqueous humor outflow physiology are discussed.
KW - Aqueous humor physiology
KW - Bumetanide
KW - Cell volume regulation
KW - Intraocular pressure
KW - Ion transport
KW - Na-K-Cl cotransport
KW - Trabecular meshwork
KW - Vascular endothelium
UR - http://www.scopus.com/inward/record.url?scp=0033278351&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033278351&partnerID=8YFLogxK
M3 - Article
C2 - 10529934
AN - SCOPUS:0033278351
VL - 8
SP - 328
EP - 339
JO - Journal of Glaucoma
JF - Journal of Glaucoma
SN - 1057-0829
IS - 5
ER -