How does the trabecular meshwork regulate outflow? Clues from the vascular endothelium

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Although it is well known that the trabecular meshwork plays a central role in regulating the outflow of aqueous humor from the eye, the cellular mechanisms and events responsible for this function are poorly understood. In contrast, the mechanisms by which vascular endothelial cells modulate the permeability of blood vessels have been more thoroughly investigated. It is hypothesized that the cells of the TM employ mechanisms similar to those observed in the vascular endothelium to modulate aqueous humor permeability. Specifically, it is hypothesized that the cells of the TM employ Na-K-Cl cotransport to modulate their intracellular volume and thus the volume of the paracellular pathways through which aqueous humor may travel. The current knowledge about the role of Na-K-Cl cotransport and volume regulation in the regulation of vascular permeability, and evidence that similar physiologic events occur in the TM are reviewed. In addition, the implications for further study of aqueous humor outflow physiology are discussed.

Original languageEnglish (US)
Pages (from-to)328-339
Number of pages12
JournalJournal of Glaucoma
Volume8
Issue number5
StatePublished - 1999

Fingerprint

Trabecular Meshwork
Aqueous Humor
Vascular Endothelium
Permeability
Capillary Permeability
Blood Vessels
Endothelial Cells

Keywords

  • Aqueous humor physiology
  • Bumetanide
  • Cell volume regulation
  • Intraocular pressure
  • Ion transport
  • Na-K-Cl cotransport
  • Trabecular meshwork
  • Vascular endothelium

ASJC Scopus subject areas

  • Ophthalmology

Cite this

How does the trabecular meshwork regulate outflow? Clues from the vascular endothelium. / Brandt, James D; O'Donnell, Martha E.

In: Journal of Glaucoma, Vol. 8, No. 5, 1999, p. 328-339.

Research output: Contribution to journalArticle

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