How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca2+-permeable (CP) α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150- anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.

Original languageEnglish (US)
Article numberpe2
JournalScience Signaling
Volume9
Issue number425
DOIs
StatePublished - Apr 26 2016

Fingerprint

AMPA Receptors
Long-Term Potentiation
Calcineurin
Phosphatases
Cyclic AMP-Dependent Protein Kinases
Phosphoric Monoester Hydrolases
Phosphotransferases
Depression
Acids
Hippocampal CA1 Region
Data storage equipment
Synaptic Transmission

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. / Hell, Johannes W.

In: Science Signaling, Vol. 9, No. 425, pe2, 26.04.2016.

Research output: Contribution to journalReview article

@article{c12f7391182b4ebcb33d3f3de9dc2a80,
title = "How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD",
abstract = "Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca2+-permeable (CP) α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150- anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.",
author = "Hell, {Johannes W}",
year = "2016",
month = "4",
day = "26",
doi = "10.1126/scisignal.aaf7067",
language = "English (US)",
volume = "9",
journal = "Science Signaling",
issn = "1937-9145",
publisher = "American Association for the Advancement of Science",
number = "425",

}

TY - JOUR

T1 - How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD

AU - Hell, Johannes W

PY - 2016/4/26

Y1 - 2016/4/26

N2 - Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca2+-permeable (CP) α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150- anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.

AB - Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca2+-permeable (CP) α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150- anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.

UR - http://www.scopus.com/inward/record.url?scp=84964721857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964721857&partnerID=8YFLogxK

U2 - 10.1126/scisignal.aaf7067

DO - 10.1126/scisignal.aaf7067

M3 - Review article

C2 - 27117250

AN - SCOPUS:84964721857

VL - 9

JO - Science Signaling

JF - Science Signaling

SN - 1937-9145

IS - 425

M1 - pe2

ER -