How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD

Johannes W Hell

doi:10.1126/scisignal.aaf7067

How Ca²⁺-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD

Johannes W Hell

Pharmacology

Research output: Contribution to journal › Review article

15 Citations (Scopus)

Abstract

Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca²⁺-permeable (CP) α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150- anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.

Original language	English (US)
Article number	pe2
Journal	Science Signaling
Volume	9
Issue number	425
DOIs	https://doi.org/10.1126/scisignal.aaf7067
State	Published - Apr 26 2016

Fingerprint

AMPA Receptors

Long-Term Potentiation

Calcineurin

Phosphatases

Cyclic AMP-Dependent Protein Kinases

Phosphoric Monoester Hydrolases

Phosphotransferases

Depression

Acids

Hippocampal CA1 Region

Data storage equipment

Synaptic Transmission

ASJC Scopus subject areas

Biochemistry
Cell Biology
Molecular Biology

Cite this

Hell, J. W. (2016). How Ca²⁺-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. Science Signaling, 9(425), [pe2]. https://doi.org/10.1126/scisignal.aaf7067

How Ca²⁺-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. / Hell, Johannes W.

In: Science Signaling, Vol. 9, No. 425, pe2, 26.04.2016.

Research output: Contribution to journal › Review article

Hell, JW 2016, 'How Ca²⁺-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD', Science Signaling, vol. 9, no. 425, pe2. https://doi.org/10.1126/scisignal.aaf7067

Hell JW. How Ca²⁺-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. Science Signaling. 2016 Apr 26;9(425). pe2. https://doi.org/10.1126/scisignal.aaf7067

Hell, Johannes W. / How Ca²⁺-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD. In: Science Signaling. 2016 ; Vol. 9, No. 425.

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10.1126/scisignal.aaf7067