Abstract
Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now demonstrate that transient postsynaptic incorporation of Ca2+-permeable (CP) α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is required for LTD in the exemplary hippocampal CA1 region in 2-week-old mice. Mechanistically, LTD depends on AKAP150-anchored protein kinase A (PKA) to promote the initial functional recruitment of CP-AMPARs during LTD induction and on AKAP150- anchored protein phosphatase 2B (PP2B) to trigger their subsequent removal as part of the lasting depression of synaptic transmission.
Original language | English (US) |
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Article number | pe2 |
Journal | Science Signaling |
Volume | 9 |
Issue number | 425 |
DOIs | |
State | Published - Apr 26 2016 |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology