How bacterial pathogens use type III and type IV secretion systems to facilitate their transmission

Mariana X. Byndloss, Fabian Rivera-Chávez, Renee M Tsolis, Andreas J Baumler

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Work on type III or type IV secretion systems (T3SSs or T4SSs) is often focused on elucidating how these sophisticated bacterial virulence factors manipulate host cell physiology to cause disease. But to fully understand their role in pathogen biology, it is important to consider whether the morbidity or mortality they trigger is somehow linked to enhancing communicability of the microbe. Recent work on Salmonella enterica and Brucella abortus provide captivating examples of how manipulation of host cells with T3SSs or T4SSs instigates distant downstream consequences that promote spread of the pathogen. It is clear from these examples that T3SSs and T4SSs are ultimately transmission factors placed under selection by an incredibly complex series of events unfolding during host pathogen interaction.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalCurrent Opinion in Microbiology
Volume35
DOIs
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'How bacterial pathogens use type III and type IV secretion systems to facilitate their transmission'. Together they form a unique fingerprint.

  • Cite this