Household pesticides and the risk of Wilms tumor

Maureen A. Cooney, Julie L. Daniels, Julie A. Ross, Norman E. Breslow, Bradley H Pollock, Andrew F. Olshan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Previous epidemiologic studies have suggested that exposure to pesticides in utero and during early childhood may increase the risk for development of childhood cancer, including Wilms tumor, a childhood kidney tumor. Obectives: In this analysis we evaluated the role of residential pesticide exposure in relation to the risk of Wilms tumor in children using data from a North American case-control study. Methods: The National Wilms Tumor Study Group (NWTSG) collected information on exposure to residential pesticides from the month before pregnancy through the diagnosis reference date using detailed phone interviews from 523 case mothers and 517 controls frequency matched on child's age and geographic region and identified by list-assisted random digit dialing. Pesticides were grouped according to type of pesticide and where they were used. Results: A slightly increased risk of Wilms tumor was found among children of mothers who reported insecticide use [odds ratio (OR) = 1.4, 95% confidence interval (CI), 1.0-1.8; adjusted for education, income, and the matching variables]. Results from all other categories of pesticides were generally close to the null. Conclusions: This study is the largest case-control study of Wilms tumor to date. We were unable to confirm earlier reports of an increased risk for Wilms tumor among those exposed to residential pesticides during pregnancy through early childhood.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalEnvironmental Health Perspectives
Volume115
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Wilms Tumor
Pesticides
tumor
Tumors
pesticide
pregnancy
Case-Control Studies
Mothers
Pregnancy
Insecticides
household
confidence interval
insecticide
Epidemiologic Studies
cancer
Neoplasms
Education
Odds Ratio
income
education

Keywords

  • Childhood cancer
  • Enviroment
  • Pediatric pesticides
  • Wilms tumor

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Cooney, M. A., Daniels, J. L., Ross, J. A., Breslow, N. E., Pollock, B. H., & Olshan, A. F. (2007). Household pesticides and the risk of Wilms tumor. Environmental Health Perspectives, 115(1), 134-137. https://doi.org/10.1289/ehp.9298

Household pesticides and the risk of Wilms tumor. / Cooney, Maureen A.; Daniels, Julie L.; Ross, Julie A.; Breslow, Norman E.; Pollock, Bradley H; Olshan, Andrew F.

In: Environmental Health Perspectives, Vol. 115, No. 1, 01.2007, p. 134-137.

Research output: Contribution to journalArticle

Cooney, MA, Daniels, JL, Ross, JA, Breslow, NE, Pollock, BH & Olshan, AF 2007, 'Household pesticides and the risk of Wilms tumor', Environmental Health Perspectives, vol. 115, no. 1, pp. 134-137. https://doi.org/10.1289/ehp.9298
Cooney MA, Daniels JL, Ross JA, Breslow NE, Pollock BH, Olshan AF. Household pesticides and the risk of Wilms tumor. Environmental Health Perspectives. 2007 Jan;115(1):134-137. https://doi.org/10.1289/ehp.9298
Cooney, Maureen A. ; Daniels, Julie L. ; Ross, Julie A. ; Breslow, Norman E. ; Pollock, Bradley H ; Olshan, Andrew F. / Household pesticides and the risk of Wilms tumor. In: Environmental Health Perspectives. 2007 ; Vol. 115, No. 1. pp. 134-137.
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