Household Dust as a Repository of Chemical Accumulation: New Insights from a Comprehensive High-Resolution Mass Spectrometric Study

Christoph Moschet, Tarun Anumol, Bonny M. Lew, Deborah H Bennett, Thomas M. Young

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Chemical exposure in household dust poses potential risks to human health but has been studied incompletely thus far. Most analytical studies have focused on one or several compound classes, with analysis performed by either liquid or gas chromatography coupled with mass spectrometry (LC-MS or GC-MS). However, a comprehensive investigation of individual dust samples is missing. The present study comprehensively characterizes chemicals in dust by applying a combination of target, suspect, and nontarget screening approaches using both LC and GC with quadrupole time-of-flight (Q/TOF) MS. First, the extraction method was optimized to streamline detection of LC-Q/TOF and GC-Q/TOF amenable compounds and was successfully validated with over 100 target compounds. Nontarget screening with GC-Q/TOF was done by spectral deconvolution followed by a library search. Suspect screening by LC-Q/TOF was carried out with an accurate mass spectral library. Finally, LC-Q/TOF nontarget screening was carried out by extracting molecular features, acquiring tandem mass spectrometric (MS/MS) spectra, and performing compound identification by use of in silico fragmentation software tools. In total, 271 chemicals could be detected in 38 dust samples, 163 of which could be unambiguously confirmed by a reference standard. Many of them, such as the plastic leachable 7,9-di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione (CAS 82304-66-3) and three organofluorine compounds, are of emerging concern and their presence in dust has been underestimated. Advantages and drawbacks of the different approaches and analytical instruments are critically discussed.

Original languageEnglish (US)
Pages (from-to)2878-2887
Number of pages10
JournalEnvironmental Science and Technology
Volume52
Issue number5
DOIs
StatePublished - Mar 6 2018
Externally publishedYes

Fingerprint

repository
Dust
dust
Screening
organofluorine
Liquid chromatography
Deconvolution
deconvolution
extraction method
Gas chromatography
Mass spectrometry
liquid chromatography
gas chromatography
fragmentation
mass spectrometry
plastic
household
chemical
Health
Plastics

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Household Dust as a Repository of Chemical Accumulation : New Insights from a Comprehensive High-Resolution Mass Spectrometric Study. / Moschet, Christoph; Anumol, Tarun; Lew, Bonny M.; Bennett, Deborah H; Young, Thomas M.

In: Environmental Science and Technology, Vol. 52, No. 5, 06.03.2018, p. 2878-2887.

Research output: Contribution to journalArticle

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