Household contact study of Bordetella pertussis infections

J. L. Deen, C. M. Mink, J. D. Cherry, P. D. Christenson, E. F. Pineda, K. Lewis, Dean A Blumberg, L. A. Ross

Research output: Contribution to journalArticle

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Abstract

Household contacts of primary pertussis cases were evaluated. Infection was determined by culture, direct fluorescent antibody assay, and serological criteria. Agglutinin titers and values of ELISA IgG and IgA antibodies to lymphocytosis-promoting factor, filamentous hemagglutinin, and pertactin were determined. In 39 households 255 subjects were exposed; 114 remained well (group 1), 53 had mild illness (group 2), and 88 had pertussis (group 3). The infection rates were 46% (group 1), 43% (group 2), and 80% (group 3). In a subgroup of subjects seen within 14-28 days of exposure, it was found that none with clinical pertussis had a value of IgG antibody to pertactin in acute-phase sera of ≥50 ELISA units (EU) per mL or an agglutinin titer of >256. Of the primary cases, 53% were ≥13 years of age. These data point out the importance of Bordetella pertussis infections in adolescents and adults as a source of infection in young children. Our subgroup data suggest that high values of antibody to pertactin and high agglutinin titers may be predictive of protection against clinical pertussis.

Original languageEnglish (US)
Pages (from-to)1211-1219
Number of pages9
JournalClinical Infectious Diseases
Volume21
Issue number5
StatePublished - 1995
Externally publishedYes

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Bordetella Infections
Bordetella pertussis
Whooping Cough
Agglutinins
Antibodies
Bordetella Virulence Factors
Immunoglobulin G
Infection
Enzyme-Linked Immunosorbent Assay
Immunoglobulin A
Serum
pertactin

ASJC Scopus subject areas

  • Immunology

Cite this

Deen, J. L., Mink, C. M., Cherry, J. D., Christenson, P. D., Pineda, E. F., Lewis, K., ... Ross, L. A. (1995). Household contact study of Bordetella pertussis infections. Clinical Infectious Diseases, 21(5), 1211-1219.

Household contact study of Bordetella pertussis infections. / Deen, J. L.; Mink, C. M.; Cherry, J. D.; Christenson, P. D.; Pineda, E. F.; Lewis, K.; Blumberg, Dean A; Ross, L. A.

In: Clinical Infectious Diseases, Vol. 21, No. 5, 1995, p. 1211-1219.

Research output: Contribution to journalArticle

Deen, JL, Mink, CM, Cherry, JD, Christenson, PD, Pineda, EF, Lewis, K, Blumberg, DA & Ross, LA 1995, 'Household contact study of Bordetella pertussis infections', Clinical Infectious Diseases, vol. 21, no. 5, pp. 1211-1219.
Deen JL, Mink CM, Cherry JD, Christenson PD, Pineda EF, Lewis K et al. Household contact study of Bordetella pertussis infections. Clinical Infectious Diseases. 1995;21(5):1211-1219.
Deen, J. L. ; Mink, C. M. ; Cherry, J. D. ; Christenson, P. D. ; Pineda, E. F. ; Lewis, K. ; Blumberg, Dean A ; Ross, L. A. / Household contact study of Bordetella pertussis infections. In: Clinical Infectious Diseases. 1995 ; Vol. 21, No. 5. pp. 1211-1219.
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