Hounsfield units are a useful predictor of pleural effusion cytological type in dogs but not in cats

Sarah J. Woods, Mathieu Spriet, Noa Safra, Derek Cissell, Dori L Borjesson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

All categories of pleural effusion subjectively display as soft tissue opacity on computed tomography (CT). Quantitative measurement using Hounsfield units (HU) has the potential to bring additional information regarding the nature of the fluid in a noninvasive way. The purposes of this retrospective cross-sectional analytical study were to compare Hounsfield units of different pleural effusion categories in dogs and cats, assess association between specific cytologic parameters and Hounsfield units, and evaluate the effect of dependent vs. nondependent aspect of the effusion pool on Hounsfield unit. A total of 111 patients (74 dogs and 37 cats) with pleural effusion, that underwent thoracic CT and diagnostic thoracocentesis, were included in the study. Effusions were cytologically categorized as exudate, transudate, modified transudate, hemorrhage, or chyle. Significant differences existed in Hounsfield units between categories in dogs (P < 0.0001) but not in cats (P = 0.334). Canine chylous effusion (6.1 ± 4.7 HU (mean ± standard deviation)) and transudate (5.6 ± 2.0) were significantly lower than exudate (20.3 ± 9.5) and hemorrhage (21.4 ± 9.2). No significant differences were found between modified transudate (13.6 ± 10.3) and other categories. Significant, weak linear correlation was identified in dogs between Hounsfield units and total protein (P = 0.018, R2 = 0.089), red blood cells (P = 0.021, R2 = 0.077), and total nucleated cells (P = 0.013, R2 = 0.089). The Hounsfield units of dependent effusion was not significantly higher than the nondependent effusion, except for canine chylous effusion (P = 0.008). Fourteen Hounsfield units was identified as the most clinically useful threshold: <14 HU identified transudate or chylous effusion with a sensitivity of 100% and a specificity of 69%. A threshold >14 HU had a specificity of 100% and a sensitivity of 69% for identifying exudate, modified transudate, or hemorrhage.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalVeterinary Radiology and Ultrasound
Volume59
Issue number4
DOIs
StatePublished - Jul 1 2018

Fingerprint

Exudates and Transudates
Pleural Effusion
Cats
Dogs
cats
computed tomography
hemorrhage
dogs
Chyle
Tomography
Hemorrhage
opacity
chest
Thorax
Cross-Sectional Studies

Keywords

  • chyle
  • computed tomography
  • exudate
  • hemorrhage
  • transudate

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hounsfield units are a useful predictor of pleural effusion cytological type in dogs but not in cats. / Woods, Sarah J.; Spriet, Mathieu; Safra, Noa; Cissell, Derek; Borjesson, Dori L.

In: Veterinary Radiology and Ultrasound, Vol. 59, No. 4, 01.07.2018, p. 405-411.

Research output: Contribution to journalArticle

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