Abstract
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.
Original language | English (US) |
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Pages (from-to) | 1166-1169 |
Number of pages | 4 |
Journal | Nature Genetics |
Volume | 46 |
Issue number | 11 |
DOIs | |
State | Published - Nov 5 2014 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics