Host specificity of bacterial pathogens

Andreas J Baumler, Ferric C. Fang

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Most pathogens are able to infect multiple hosts but some are highly adapted to a single-host species. A detailed understanding of the basis of host specificity can provide important insights into molecular pathogenesis, the evolution of pathogenic microbes, and the potential for pathogens to cross the species barrier to infect new hosts. Comparative genomics and the development of humanized mouse models have provided important new tools with which to explore the basis of generalism and specialism. This review will examine host specificity of bacterial pathogens with a focus on generalist and specialist serovars of Salmonella enterica.

Original languageEnglish (US)
Article numbera010041
JournalCold Spring Harbor perspectives in medicine
Volume3
Issue number12
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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