Host-pathogen interactions in malaria: Cross-kingdom signaling and mitochondrial regulation

Shirley Luckhart, Nazzy Pakpour, Cecilia R Giulivi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Malaria parasite-host interactions are complex and have confounded available drugs and the development of vaccines. Further, we now appreciate that interventions for malaria elimination and eradication must include therapeutics with intrinsic transmission blocking activity to treat the patient and prevent disease spread. Studies over the past 15 years have revealed significant conservation in the response to infection in mosquito and human hosts. More recently, we have recognized that conserved cell signaling cascades in mosquitoes and humans dictate infection outcome through the regulation of mitochondrial function and biogenesis, which feed back to host immunity, basic intermediary metabolism, and stress responses. These responses - reflected clearly in the primeval insect host - provide fertile ground for innovative strategies for both treatment and transmission blocking.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalCurrent Opinion in Immunology
Volume36
DOIs
StatePublished - Oct 1 2015

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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