Host-pathogen interactions in malaria

Cross-kingdom signaling and mitochondrial regulation

Shirley Luckhart, Nazzy Pakpour, Cecilia R Giulivi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Malaria parasite-host interactions are complex and have confounded available drugs and the development of vaccines. Further, we now appreciate that interventions for malaria elimination and eradication must include therapeutics with intrinsic transmission blocking activity to treat the patient and prevent disease spread. Studies over the past 15 years have revealed significant conservation in the response to infection in mosquito and human hosts. More recently, we have recognized that conserved cell signaling cascades in mosquitoes and humans dictate infection outcome through the regulation of mitochondrial function and biogenesis, which feed back to host immunity, basic intermediary metabolism, and stress responses. These responses - reflected clearly in the primeval insect host - provide fertile ground for innovative strategies for both treatment and transmission blocking.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalCurrent Opinion in Immunology
Volume36
DOIs
StatePublished - Oct 1 2015

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Host-Pathogen Interactions
Culicidae
Malaria
Host-Parasite Interactions
Organelle Biogenesis
Infection
Insects
Immunity
Vaccines
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Host-pathogen interactions in malaria : Cross-kingdom signaling and mitochondrial regulation. / Luckhart, Shirley; Pakpour, Nazzy; Giulivi, Cecilia R.

In: Current Opinion in Immunology, Vol. 36, 01.10.2015, p. 73-79.

Research output: Contribution to journalArticle

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