Host-pathogen interactions: A proteomic view

Celia G. Zhang, Brett A. Chromy, Sandra L. McCutchen-Maloney

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Host-pathogen interactions reflect the balance of host defenses and pathogen virulence mechanisms. Advances in proteomic technologies now afford opportunities to compare protein content between complex biologic systems ranging from cells to animals and clinical samples. Thus, it is now possible to characterize host-pathogen interactions from a global proteomic view. Most reports to date focus on cataloging protein content of pathogens and identifying virulence-associated proteins or proteomic alterations in host response. A more in-depth understanding of host-pathogen interactions has the potential to improve our mechanistic understanding of pathogenicity and virulence, thereby defining novel therapeutic and vaccine targets. In addition, proteomic characterization of the host response can provide pathogen-specific host biomarkers for rapid pathogen detection and characterization, as well as for early and specific detection of infectious diseases. A review of host-pathogen interactions focusing on proteomic analyses of both pathogen and host will be presented. Relevant genomic studies and host model systems will be also be discussed.

Original languageEnglish (US)
Pages (from-to)187-202
Number of pages16
JournalExpert Review of Proteomics
Issue number2
StatePublished - Apr 2005
Externally publishedYes


  • Biodefense
  • Host-pathogen interactions
  • Infectious diseases
  • Pathogenicity
  • Presymptomatic detection
  • Proteomics
  • Therapeutics
  • Virulence

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Biotechnology


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