Abstract
We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1443-1447 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 205 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 1 2012 |
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ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
Cite this
Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A. / Hubbard, Jonathan J.; Greenwell-Wild, Teresa; Barrett, Lisa; Yang, Jun; Lempicki, Richard A.; Wahl, Sharon M.; Asmuth, David; Murphy, Robert L.; Pollard, Richard B; Kottilil, Shyam.
In: Journal of Infectious Diseases, Vol. 205, No. 9, 01.05.2012, p. 1443-1447.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A
AU - Hubbard, Jonathan J.
AU - Greenwell-Wild, Teresa
AU - Barrett, Lisa
AU - Yang, Jun
AU - Lempicki, Richard A.
AU - Wahl, Sharon M.
AU - Asmuth, David
AU - Murphy, Robert L.
AU - Pollard, Richard B
AU - Kottilil, Shyam
PY - 2012/5/1
Y1 - 2012/5/1
N2 - We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
AB - We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
UR - http://www.scopus.com/inward/record.url?scp=84861543028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861543028&partnerID=8YFLogxK
U2 - 10.1093/infdis/jis211
DO - 10.1093/infdis/jis211
M3 - Article
VL - 205
SP - 1443
EP - 1447
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -