Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A

Jonathan J. Hubbard, Teresa Greenwell-Wild, Lisa Barrett, Jun Yang, Richard A. Lempicki, Sharon M. Wahl, David Asmuth, Robert L. Murphy, Richard B Pollard, Shyam Kottilil

Research output: Contribution to journalArticle

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Abstract

We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r =-0.7; P <. 05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r 2 = 0.87, p =. 003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.

Original languageEnglish (US)
Pages (from-to)1443-1447
Number of pages5
JournalJournal of Infectious Diseases
Volume205
Issue number9
DOIs
StatePublished - May 1 2012

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Interferons
HIV-1
HIV
Gene Expression
Genes
Virus Diseases
Therapeutics
Volunteers
peginterferon alfa-2a

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

Hubbard, J. J., Greenwell-Wild, T., Barrett, L., Yang, J., Lempicki, R. A., Wahl, S. M., ... Kottilil, S. (2012). Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A. Journal of Infectious Diseases, 205(9), 1443-1447. https://doi.org/10.1093/infdis/jis211

Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A. / Hubbard, Jonathan J.; Greenwell-Wild, Teresa; Barrett, Lisa; Yang, Jun; Lempicki, Richard A.; Wahl, Sharon M.; Asmuth, David; Murphy, Robert L.; Pollard, Richard B; Kottilil, Shyam.

In: Journal of Infectious Diseases, Vol. 205, No. 9, 01.05.2012, p. 1443-1447.

Research output: Contribution to journalArticle

Hubbard, JJ, Greenwell-Wild, T, Barrett, L, Yang, J, Lempicki, RA, Wahl, SM, Asmuth, D, Murphy, RL, Pollard, RB & Kottilil, S 2012, 'Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A', Journal of Infectious Diseases, vol. 205, no. 9, pp. 1443-1447. https://doi.org/10.1093/infdis/jis211
Hubbard, Jonathan J. ; Greenwell-Wild, Teresa ; Barrett, Lisa ; Yang, Jun ; Lempicki, Richard A. ; Wahl, Sharon M. ; Asmuth, David ; Murphy, Robert L. ; Pollard, Richard B ; Kottilil, Shyam. / Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon ALFA-2A. In: Journal of Infectious Diseases. 2012 ; Vol. 205, No. 9. pp. 1443-1447.
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