Hormone therapy: Physiological complexity belies therapeutic simplicity

Judith L Turgeon, Donald P. McDonnell, Kathryn A. Martin, Phyllis M. Wise

Research output: Contribution to journalArticle

234 Citations (Scopus)

Abstract

The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.

Original languageEnglish (US)
Pages (from-to)1269-1273
Number of pages5
JournalScience
Volume304
Issue number5675
DOIs
StatePublished - May 28 2004

Fingerprint

Hormones
Estrogens
Endocrinology
Women's Health
Insurance Benefits
Progestins
Therapeutics
Menopause
Progesterone
Steroids
Research Personnel
Pharmaceutical Preparations
Clinical Studies

ASJC Scopus subject areas

  • General

Cite this

Hormone therapy : Physiological complexity belies therapeutic simplicity. / Turgeon, Judith L; McDonnell, Donald P.; Martin, Kathryn A.; Wise, Phyllis M.

In: Science, Vol. 304, No. 5675, 28.05.2004, p. 1269-1273.

Research output: Contribution to journalArticle

Turgeon, JL, McDonnell, DP, Martin, KA & Wise, PM 2004, 'Hormone therapy: Physiological complexity belies therapeutic simplicity', Science, vol. 304, no. 5675, pp. 1269-1273. https://doi.org/10.1126/science.1096725
Turgeon, Judith L ; McDonnell, Donald P. ; Martin, Kathryn A. ; Wise, Phyllis M. / Hormone therapy : Physiological complexity belies therapeutic simplicity. In: Science. 2004 ; Vol. 304, No. 5675. pp. 1269-1273.
@article{08cdc428392049e1a4038dca69214b8b,
title = "Hormone therapy: Physiological complexity belies therapeutic simplicity",
abstract = "The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.",
author = "Turgeon, {Judith L} and McDonnell, {Donald P.} and Martin, {Kathryn A.} and Wise, {Phyllis M.}",
year = "2004",
month = "5",
day = "28",
doi = "10.1126/science.1096725",
language = "English (US)",
volume = "304",
pages = "1269--1273",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5675",

}

TY - JOUR

T1 - Hormone therapy

T2 - Physiological complexity belies therapeutic simplicity

AU - Turgeon, Judith L

AU - McDonnell, Donald P.

AU - Martin, Kathryn A.

AU - Wise, Phyllis M.

PY - 2004/5/28

Y1 - 2004/5/28

N2 - The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.

AB - The results of the Women's Health Initiative, a study anticipated to provide definitive answers about health benefits and risks of postmenopausal hormone therapy, have generated debate and confusion among clinicians, researchers, and the lay public. The ovarian hormones estrogen and progesterone, which decline at menopause, normally elicit complex tissue-specific responses throughout the body. Major advances are providing a detailed molecular definition of how that differential action is achieved. Here we review estrogen and progestin actions, discuss how effectively knowledge of steroid hormone endocrinology has been incorporated into clinical studies, and consider the impact on modern hormone therapy protocols and pharmaceutical development.

UR - http://www.scopus.com/inward/record.url?scp=2542540731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542540731&partnerID=8YFLogxK

U2 - 10.1126/science.1096725

DO - 10.1126/science.1096725

M3 - Article

C2 - 15166356

AN - SCOPUS:2542540731

VL - 304

SP - 1269

EP - 1273

JO - Science

JF - Science

SN - 0036-8075

IS - 5675

ER -