Hormone replacement therapy and invasive and borderline epithelial ovarian cancer risk

Paul K. Mills; Deborah G. Riordan; Rosemary D Cress; David F. Goldsmith

doi:10.1016/j.cdp.2004.11.002

Hormone replacement therapy and invasive and borderline epithelial ovarian cancer risk

Paul K. Mills, Deborah G. Riordan, Rosemary D Cress, David F. Goldsmith

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Risk of epithelial ovarian cancer (EOC) attendant to use of hormone replacement therapy (HRT) was evaluated in a population-based case-control study of newly diagnosed EOC cases (n = 256) and randomly selected population controls (n = 1122). Telephone interviews were conducted to obtain information on history of HRT and several other covariates. Multivariate adjusted odds ratio (OR) and 95% confidence intervals (CI) were derived from unconditional logistic regression. The OR for ever use of HRT was 1.39 (95% CI: 1.01-1.93) compared to never use. Long-term use (>10 years) increased risk (OR: 1.62, CI: 1.05-2.50) although the trend p-value for duration of use was of only borderline significance (p = 0.08). The relationship was stronger in women without hysterectomy (OR: 1.66, 95% CI: 1.14-2.41) or tubal ligation (OR: 1.56, 95% CI: 1.08-2.26). In this study, use of HRT is associated with an increased risk of EOC.

Original language	English (US)
Pages (from-to)	124-132
Number of pages	9
Journal	Cancer Detection and Prevention
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.cdp.2004.11.002
State	Published - 2005
Externally published	Yes

Keywords

Epidemiology
Gynecologic cancer
Hormone replacement therapy
Risk factors

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Hormone replacement therapy and invasive and borderline epithelial ovarian cancer risk",

abstract = "Risk of epithelial ovarian cancer (EOC) attendant to use of hormone replacement therapy (HRT) was evaluated in a population-based case-control study of newly diagnosed EOC cases (n = 256) and randomly selected population controls (n = 1122). Telephone interviews were conducted to obtain information on history of HRT and several other covariates. Multivariate adjusted odds ratio (OR) and 95% confidence intervals (CI) were derived from unconditional logistic regression. The OR for ever use of HRT was 1.39 (95% CI: 1.01-1.93) compared to never use. Long-term use (>10 years) increased risk (OR: 1.62, CI: 1.05-2.50) although the trend p-value for duration of use was of only borderline significance (p = 0.08). The relationship was stronger in women without hysterectomy (OR: 1.66, 95% CI: 1.14-2.41) or tubal ligation (OR: 1.56, 95% CI: 1.08-2.26). In this study, use of HRT is associated with an increased risk of EOC.",

keywords = "Epidemiology, Gynecologic cancer, Hormone replacement therapy, Risk factors",

author = "Mills, {Paul K.} and Riordan, {Deborah G.} and Cress, {Rosemary D} and Goldsmith, {David F.}",

year = "2005",

doi = "10.1016/j.cdp.2004.11.002",

language = "English (US)",

volume = "29",

pages = "124--132",

journal = "Cancer Epidemiology",

issn = "1877-7821",

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T1 - Hormone replacement therapy and invasive and borderline epithelial ovarian cancer risk

AU - Mills, Paul K.

AU - Riordan, Deborah G.

AU - Cress, Rosemary D

AU - Goldsmith, David F.

PY - 2005

Y1 - 2005

N2 - Risk of epithelial ovarian cancer (EOC) attendant to use of hormone replacement therapy (HRT) was evaluated in a population-based case-control study of newly diagnosed EOC cases (n = 256) and randomly selected population controls (n = 1122). Telephone interviews were conducted to obtain information on history of HRT and several other covariates. Multivariate adjusted odds ratio (OR) and 95% confidence intervals (CI) were derived from unconditional logistic regression. The OR for ever use of HRT was 1.39 (95% CI: 1.01-1.93) compared to never use. Long-term use (>10 years) increased risk (OR: 1.62, CI: 1.05-2.50) although the trend p-value for duration of use was of only borderline significance (p = 0.08). The relationship was stronger in women without hysterectomy (OR: 1.66, 95% CI: 1.14-2.41) or tubal ligation (OR: 1.56, 95% CI: 1.08-2.26). In this study, use of HRT is associated with an increased risk of EOC.

AB - Risk of epithelial ovarian cancer (EOC) attendant to use of hormone replacement therapy (HRT) was evaluated in a population-based case-control study of newly diagnosed EOC cases (n = 256) and randomly selected population controls (n = 1122). Telephone interviews were conducted to obtain information on history of HRT and several other covariates. Multivariate adjusted odds ratio (OR) and 95% confidence intervals (CI) were derived from unconditional logistic regression. The OR for ever use of HRT was 1.39 (95% CI: 1.01-1.93) compared to never use. Long-term use (>10 years) increased risk (OR: 1.62, CI: 1.05-2.50) although the trend p-value for duration of use was of only borderline significance (p = 0.08). The relationship was stronger in women without hysterectomy (OR: 1.66, 95% CI: 1.14-2.41) or tubal ligation (OR: 1.56, 95% CI: 1.08-2.26). In this study, use of HRT is associated with an increased risk of EOC.

KW - Epidemiology

KW - Gynecologic cancer

KW - Hormone replacement therapy

KW - Risk factors

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JO - Cancer Epidemiology

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SN - 1877-7821

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Hormone replacement therapy and invasive and borderline epithelial ovarian cancer risk

Abstract

Keywords

ASJC Scopus subject areas

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