Hormone and fertility drug use and the risk of neuroblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group

Andrew F. Olshan, Joanna Smith, Michael N. Cook, Seymour Grufferman, Bradley H Pollock, Daniel O. Stram, Robert C. Seeger, A. Thomas Look, Susan L. Cohn, Robert P. Castleberry, Melissa L. Bondy

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Previous epidemiologic studies have suggested an association between maternal sex hormone use during pregnancy, including infertility medication, and an increased risk of neuroblastoma in the offspring. The authors conducted a case-control interview study from 1992 to 1996 that included 504 children less than 19 years of age whose newly diagnosed neuroblastoma was identified by two national collaborative clinical trials groups in the United States and Canada, the Children's Cancer Group and the Pediatric Oncology Group. Controls, matched to cases on age, were identified by random digit dialing. No association was found for use of oral contraceptives before or during pregnancy (first trimester odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.5, 2.1). The odds ratio was slightly elevated for history of infertility (OR = 1.4, 95% Ch 0.9, 2.1) and ever use of any infertility medication (OR = 1.2, 95% Ch 0.7, 2.2). Specifically, ever use of clomiphene was associated with a 1.6-fold increased risk (95% CI: 0.8, 3.0) but not periconceptionally or during the index pregnancy. A suggestive pattern was found for gender of the offspring, with an increased risk for males but not for females after exposure to oral contraceptives or clomiphene. This study did not find consistent and large increased risks for maternal use of hormones, but the suggestion of an association for male offspring requires further consideration.

Original languageEnglish (US)
Pages (from-to)930-938
Number of pages9
JournalAmerican Journal of Epidemiology
Volume150
Issue number9
StatePublished - Nov 1 1999
Externally publishedYes

Fingerprint

Fertility Agents
Neuroblastoma
Odds Ratio
Hormones
Infertility
Pediatrics
Clomiphene
Oral Contraceptives
Neoplasms
Mothers
Confidence Intervals
Pregnancy
Gonadal Steroid Hormones
First Pregnancy Trimester
Canada
Case-Control Studies
Epidemiologic Studies
Clinical Trials
Interviews

Keywords

  • 8 fertility agents
  • Child
  • Hormones
  • Neuroblastoma
  • Pregnancy
  • Sex

ASJC Scopus subject areas

  • Epidemiology

Cite this

Hormone and fertility drug use and the risk of neuroblastoma : A report from the Children's Cancer Group and the Pediatric Oncology Group. / Olshan, Andrew F.; Smith, Joanna; Cook, Michael N.; Grufferman, Seymour; Pollock, Bradley H; Stram, Daniel O.; Seeger, Robert C.; Look, A. Thomas; Cohn, Susan L.; Castleberry, Robert P.; Bondy, Melissa L.

In: American Journal of Epidemiology, Vol. 150, No. 9, 01.11.1999, p. 930-938.

Research output: Contribution to journalArticle

Olshan, AF, Smith, J, Cook, MN, Grufferman, S, Pollock, BH, Stram, DO, Seeger, RC, Look, AT, Cohn, SL, Castleberry, RP & Bondy, ML 1999, 'Hormone and fertility drug use and the risk of neuroblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group', American Journal of Epidemiology, vol. 150, no. 9, pp. 930-938.
Olshan, Andrew F. ; Smith, Joanna ; Cook, Michael N. ; Grufferman, Seymour ; Pollock, Bradley H ; Stram, Daniel O. ; Seeger, Robert C. ; Look, A. Thomas ; Cohn, Susan L. ; Castleberry, Robert P. ; Bondy, Melissa L. / Hormone and fertility drug use and the risk of neuroblastoma : A report from the Children's Cancer Group and the Pediatric Oncology Group. In: American Journal of Epidemiology. 1999 ; Vol. 150, No. 9. pp. 930-938.
@article{d2a68a70e51c4cde8f6f6ebbd140ffa6,
title = "Hormone and fertility drug use and the risk of neuroblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group",
abstract = "Previous epidemiologic studies have suggested an association between maternal sex hormone use during pregnancy, including infertility medication, and an increased risk of neuroblastoma in the offspring. The authors conducted a case-control interview study from 1992 to 1996 that included 504 children less than 19 years of age whose newly diagnosed neuroblastoma was identified by two national collaborative clinical trials groups in the United States and Canada, the Children's Cancer Group and the Pediatric Oncology Group. Controls, matched to cases on age, were identified by random digit dialing. No association was found for use of oral contraceptives before or during pregnancy (first trimester odds ratio (OR) = 1.0, 95{\%} confidence interval (CI): 0.5, 2.1). The odds ratio was slightly elevated for history of infertility (OR = 1.4, 95{\%} Ch 0.9, 2.1) and ever use of any infertility medication (OR = 1.2, 95{\%} Ch 0.7, 2.2). Specifically, ever use of clomiphene was associated with a 1.6-fold increased risk (95{\%} CI: 0.8, 3.0) but not periconceptionally or during the index pregnancy. A suggestive pattern was found for gender of the offspring, with an increased risk for males but not for females after exposure to oral contraceptives or clomiphene. This study did not find consistent and large increased risks for maternal use of hormones, but the suggestion of an association for male offspring requires further consideration.",
keywords = "8 fertility agents, Child, Hormones, Neuroblastoma, Pregnancy, Sex",
author = "Olshan, {Andrew F.} and Joanna Smith and Cook, {Michael N.} and Seymour Grufferman and Pollock, {Bradley H} and Stram, {Daniel O.} and Seeger, {Robert C.} and Look, {A. Thomas} and Cohn, {Susan L.} and Castleberry, {Robert P.} and Bondy, {Melissa L.}",
year = "1999",
month = "11",
day = "1",
language = "English (US)",
volume = "150",
pages = "930--938",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Hormone and fertility drug use and the risk of neuroblastoma

T2 - A report from the Children's Cancer Group and the Pediatric Oncology Group

AU - Olshan, Andrew F.

AU - Smith, Joanna

AU - Cook, Michael N.

AU - Grufferman, Seymour

AU - Pollock, Bradley H

AU - Stram, Daniel O.

AU - Seeger, Robert C.

AU - Look, A. Thomas

AU - Cohn, Susan L.

AU - Castleberry, Robert P.

AU - Bondy, Melissa L.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - Previous epidemiologic studies have suggested an association between maternal sex hormone use during pregnancy, including infertility medication, and an increased risk of neuroblastoma in the offspring. The authors conducted a case-control interview study from 1992 to 1996 that included 504 children less than 19 years of age whose newly diagnosed neuroblastoma was identified by two national collaborative clinical trials groups in the United States and Canada, the Children's Cancer Group and the Pediatric Oncology Group. Controls, matched to cases on age, were identified by random digit dialing. No association was found for use of oral contraceptives before or during pregnancy (first trimester odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.5, 2.1). The odds ratio was slightly elevated for history of infertility (OR = 1.4, 95% Ch 0.9, 2.1) and ever use of any infertility medication (OR = 1.2, 95% Ch 0.7, 2.2). Specifically, ever use of clomiphene was associated with a 1.6-fold increased risk (95% CI: 0.8, 3.0) but not periconceptionally or during the index pregnancy. A suggestive pattern was found for gender of the offspring, with an increased risk for males but not for females after exposure to oral contraceptives or clomiphene. This study did not find consistent and large increased risks for maternal use of hormones, but the suggestion of an association for male offspring requires further consideration.

AB - Previous epidemiologic studies have suggested an association between maternal sex hormone use during pregnancy, including infertility medication, and an increased risk of neuroblastoma in the offspring. The authors conducted a case-control interview study from 1992 to 1996 that included 504 children less than 19 years of age whose newly diagnosed neuroblastoma was identified by two national collaborative clinical trials groups in the United States and Canada, the Children's Cancer Group and the Pediatric Oncology Group. Controls, matched to cases on age, were identified by random digit dialing. No association was found for use of oral contraceptives before or during pregnancy (first trimester odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.5, 2.1). The odds ratio was slightly elevated for history of infertility (OR = 1.4, 95% Ch 0.9, 2.1) and ever use of any infertility medication (OR = 1.2, 95% Ch 0.7, 2.2). Specifically, ever use of clomiphene was associated with a 1.6-fold increased risk (95% CI: 0.8, 3.0) but not periconceptionally or during the index pregnancy. A suggestive pattern was found for gender of the offspring, with an increased risk for males but not for females after exposure to oral contraceptives or clomiphene. This study did not find consistent and large increased risks for maternal use of hormones, but the suggestion of an association for male offspring requires further consideration.

KW - 8 fertility agents

KW - Child

KW - Hormones

KW - Neuroblastoma

KW - Pregnancy

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=0033230653&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033230653&partnerID=8YFLogxK

M3 - Article

C2 - 10547138

AN - SCOPUS:0033230653

VL - 150

SP - 930

EP - 938

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 9

ER -