Hormonal therapies for hidradenitis suppurativa: Review

Ashley K. Clark, Rebecca L. Quinonez, Suzana Saric, Raja K Sivamani

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Hidradenitis suppurativa is a recurrent inflammatory skin condition characterized by abscesses and boils, predominantly in the groin, armpit, and buttocks areas. HS is not a life-threatening condition, but severely impairs quality of life in those affected. Finding a successful treatment approach for HS has been challenging, in part because of the lack of a goldstandard treatment method, limited research-based information, and the nature of clinical variation in the disease. Treatment commonly consists of antibiotics, anti-inflammatory therapy, hormonal therapy, and more invasive clinical procedures. Treatment is chosen by the degree of severity by which the condition presents and is modified accordingly. This review describes the roles of hormones in the pathogenesis of hidradenitis suppurativa and describes the use of hormonal therapy such as, finasteride, dutasteride, spironolactone, and oral contraceptives. The outcomes of the use of these modalities in various clinical studies are summarized.

Original languageEnglish (US)
Article number1
JournalDermatology Online Journal
Volume23
Issue number10
StatePublished - Oct 1 2017

Keywords

  • Acne inversa
  • Androgens
  • Estrogens
  • Hidradenitis suppurativa
  • Hormones
  • Therapeutics

ASJC Scopus subject areas

  • Dermatology

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