Abstract
Serum concentrations of lipoprotein (a) [Lp (a)] were determined in two groups of elderly males suffering from prostatic carcinoma, who were randomized to treatment with estrogen (n = 15) or orchidectomy (n = 16). Estrogen was given as oral ethinylestradiol, 150 μg daily, combined with intramuscular polyestradiol phosphate, 80 mg/mo. The baseline levels were similar in both groups, but 6 mo after initiation of therapy, serum Lp (a) levels were decreased ∼ 50% in the estrogen-treated group (P < 0.001) in contrast to a 20% increase (P < 0.01) in the orchidectomized group. Concomitantly, LDL cholesterol decreased by 30% and HDL cholesterol increased by almost 60% in the estrogen-treated patients. There was no relationship between the change in LDL cholesterol and Lp (a) reduction. In conclusion, Lp (a) levels in males were found to drastically decrease upon estrogen treatment and to increase after orchidectomy, suggesting that sex hormones, and particularly estrogens, exert a regulatory role on the serum Lp (a) level in man.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1166-1171 |
| Number of pages | 6 |
| Journal | Journal of Clinical Investigation |
| Volume | 89 |
| Issue number | 4 |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Coronary heart disease
- Estrogen
- LDL receptors
- Lp (a) lipoprotein
- Orchidectomy
ASJC Scopus subject areas
- Medicine(all)
Cite this
Hormonal regulation of serum Lp (a) levels : Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma. / Henriksson, Peter; Angelin, Bo; Berglund, Lars.
In: Journal of Clinical Investigation, Vol. 89, No. 4, 1992, p. 1166-1171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormonal regulation of serum Lp (a) levels
T2 - Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma
AU - Henriksson, Peter
AU - Angelin, Bo
AU - Berglund, Lars
PY - 1992
Y1 - 1992
N2 - Serum concentrations of lipoprotein (a) [Lp (a)] were determined in two groups of elderly males suffering from prostatic carcinoma, who were randomized to treatment with estrogen (n = 15) or orchidectomy (n = 16). Estrogen was given as oral ethinylestradiol, 150 μg daily, combined with intramuscular polyestradiol phosphate, 80 mg/mo. The baseline levels were similar in both groups, but 6 mo after initiation of therapy, serum Lp (a) levels were decreased ∼ 50% in the estrogen-treated group (P < 0.001) in contrast to a 20% increase (P < 0.01) in the orchidectomized group. Concomitantly, LDL cholesterol decreased by 30% and HDL cholesterol increased by almost 60% in the estrogen-treated patients. There was no relationship between the change in LDL cholesterol and Lp (a) reduction. In conclusion, Lp (a) levels in males were found to drastically decrease upon estrogen treatment and to increase after orchidectomy, suggesting that sex hormones, and particularly estrogens, exert a regulatory role on the serum Lp (a) level in man.
AB - Serum concentrations of lipoprotein (a) [Lp (a)] were determined in two groups of elderly males suffering from prostatic carcinoma, who were randomized to treatment with estrogen (n = 15) or orchidectomy (n = 16). Estrogen was given as oral ethinylestradiol, 150 μg daily, combined with intramuscular polyestradiol phosphate, 80 mg/mo. The baseline levels were similar in both groups, but 6 mo after initiation of therapy, serum Lp (a) levels were decreased ∼ 50% in the estrogen-treated group (P < 0.001) in contrast to a 20% increase (P < 0.01) in the orchidectomized group. Concomitantly, LDL cholesterol decreased by 30% and HDL cholesterol increased by almost 60% in the estrogen-treated patients. There was no relationship between the change in LDL cholesterol and Lp (a) reduction. In conclusion, Lp (a) levels in males were found to drastically decrease upon estrogen treatment and to increase after orchidectomy, suggesting that sex hormones, and particularly estrogens, exert a regulatory role on the serum Lp (a) level in man.
KW - Coronary heart disease
KW - Estrogen
KW - LDL receptors
KW - Lp (a) lipoprotein
KW - Orchidectomy
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UR - http://www.scopus.com/inward/citedby.url?scp=0026628106&partnerID=8YFLogxK
M3 - Article
C2 - 1532586
AN - SCOPUS:0026628106
VL - 89
SP - 1166
EP - 1171
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
SN - 0021-9738
IS - 4
ER -