Hormonal regulation of serum Lp (a) levels: Opposite effects after estrogen treatment and orchidectomy in males with prostatic carcinoma

Peter Henriksson, Bo Angelin, Lars Berglund

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

Serum concentrations of lipoprotein (a) [Lp (a)] were determined in two groups of elderly males suffering from prostatic carcinoma, who were randomized to treatment with estrogen (n = 15) or orchidectomy (n = 16). Estrogen was given as oral ethinylestradiol, 150 μg daily, combined with intramuscular polyestradiol phosphate, 80 mg/mo. The baseline levels were similar in both groups, but 6 mo after initiation of therapy, serum Lp (a) levels were decreased ∼ 50% in the estrogen-treated group (P < 0.001) in contrast to a 20% increase (P < 0.01) in the orchidectomized group. Concomitantly, LDL cholesterol decreased by 30% and HDL cholesterol increased by almost 60% in the estrogen-treated patients. There was no relationship between the change in LDL cholesterol and Lp (a) reduction. In conclusion, Lp (a) levels in males were found to drastically decrease upon estrogen treatment and to increase after orchidectomy, suggesting that sex hormones, and particularly estrogens, exert a regulatory role on the serum Lp (a) level in man.

Original languageEnglish (US)
Pages (from-to)1166-1171
Number of pages6
JournalJournal of Clinical Investigation
Volume89
Issue number4
StatePublished - 1992
Externally publishedYes

Keywords

  • Coronary heart disease
  • Estrogen
  • LDL receptors
  • Lp (a) lipoprotein
  • Orchidectomy

ASJC Scopus subject areas

  • Medicine(all)

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