Hormonal regulation of serum lipoprotein(a) levels: Contrasting effects of growth hormone and insulin-like growth factor-I

Hans Olivecrona, Anna G. Johansson, Erik Lindh, Sverker Ljunghall, Lars Berglund, Bo Angelin

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

In response to treatment with growth hormone, serum levels of lipoprotein(a) increase, while those of LDL cholesterol decrease. To establish if increased levels of insulin-like growth factor-I may be of importance for these changes, we analyzed serum lipoprotein concentrations in II male patients with idiopathic osteoporosis who were treated with growth hormone (2 IU · m-2 · d-1) or insulin-like growth factor-I (80 μg · kg-1 · d-1) in a randomized, double-blind, cross-over study. LDL cholesterol was reduced by 0.7 mmol/L (P<.01) during growth hormone treatment but was not affected when the same patients received insulin-like growth factor-I. In contrast, mean lipoprotein(a) levels increased from 519 to 571 mg/L (P<.03) in response to growth hormone but were reduced from 538 to 478 mg/L (P<.04) during treatment with insulin-like growth factor-I. These results indicate that growth hormone exerts its effects on lipoprotein metabolism independent of insulin-like growth factor-I. Furthermore, the results suggest that treatment with insulin-like growth factor-I may reduce lipoprotein(a) levels.

Original languageEnglish (US)
Pages (from-to)847-849
Number of pages3
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume15
Issue number7
StatePublished - Jul 1995
Externally publishedYes

Keywords

  • growth hormone
  • insulin-like growth factor-I
  • lipoprotein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Hormonal regulation of serum lipoprotein(a) levels: Contrasting effects of growth hormone and insulin-like growth factor-I'. Together they form a unique fingerprint.

  • Cite this