Abstract
In response to treatment with growth hormone, serum levels of lipoprotein(a) increase, while those of LDL cholesterol decrease. To establish if increased levels of insulin-like growth factor-I may be of importance for these changes, we analyzed serum lipoprotein concentrations in II male patients with idiopathic osteoporosis who were treated with growth hormone (2 IU · m-2 · d-1) or insulin-like growth factor-I (80 μg · kg-1 · d-1) in a randomized, double-blind, cross-over study. LDL cholesterol was reduced by 0.7 mmol/L (P<.01) during growth hormone treatment but was not affected when the same patients received insulin-like growth factor-I. In contrast, mean lipoprotein(a) levels increased from 519 to 571 mg/L (P<.03) in response to growth hormone but were reduced from 538 to 478 mg/L (P<.04) during treatment with insulin-like growth factor-I. These results indicate that growth hormone exerts its effects on lipoprotein metabolism independent of insulin-like growth factor-I. Furthermore, the results suggest that treatment with insulin-like growth factor-I may reduce lipoprotein(a) levels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 847-849 |
| Number of pages | 3 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 15 |
| Issue number | 7 |
| State | Published - Jul 1995 |
| Externally published | Yes |
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Keywords
- growth hormone
- insulin-like growth factor-I
- lipoprotein
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Hormonal regulation of serum lipoprotein(a) levels : Contrasting effects of growth hormone and insulin-like growth factor-I. / Olivecrona, Hans; Johansson, Anna G.; Lindh, Erik; Ljunghall, Sverker; Berglund, Lars; Angelin, Bo.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 15, No. 7, 07.1995, p. 847-849.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormonal regulation of serum lipoprotein(a) levels
T2 - Contrasting effects of growth hormone and insulin-like growth factor-I
AU - Olivecrona, Hans
AU - Johansson, Anna G.
AU - Lindh, Erik
AU - Ljunghall, Sverker
AU - Berglund, Lars
AU - Angelin, Bo
PY - 1995/7
Y1 - 1995/7
N2 - In response to treatment with growth hormone, serum levels of lipoprotein(a) increase, while those of LDL cholesterol decrease. To establish if increased levels of insulin-like growth factor-I may be of importance for these changes, we analyzed serum lipoprotein concentrations in II male patients with idiopathic osteoporosis who were treated with growth hormone (2 IU · m-2 · d-1) or insulin-like growth factor-I (80 μg · kg-1 · d-1) in a randomized, double-blind, cross-over study. LDL cholesterol was reduced by 0.7 mmol/L (P<.01) during growth hormone treatment but was not affected when the same patients received insulin-like growth factor-I. In contrast, mean lipoprotein(a) levels increased from 519 to 571 mg/L (P<.03) in response to growth hormone but were reduced from 538 to 478 mg/L (P<.04) during treatment with insulin-like growth factor-I. These results indicate that growth hormone exerts its effects on lipoprotein metabolism independent of insulin-like growth factor-I. Furthermore, the results suggest that treatment with insulin-like growth factor-I may reduce lipoprotein(a) levels.
AB - In response to treatment with growth hormone, serum levels of lipoprotein(a) increase, while those of LDL cholesterol decrease. To establish if increased levels of insulin-like growth factor-I may be of importance for these changes, we analyzed serum lipoprotein concentrations in II male patients with idiopathic osteoporosis who were treated with growth hormone (2 IU · m-2 · d-1) or insulin-like growth factor-I (80 μg · kg-1 · d-1) in a randomized, double-blind, cross-over study. LDL cholesterol was reduced by 0.7 mmol/L (P<.01) during growth hormone treatment but was not affected when the same patients received insulin-like growth factor-I. In contrast, mean lipoprotein(a) levels increased from 519 to 571 mg/L (P<.03) in response to growth hormone but were reduced from 538 to 478 mg/L (P<.04) during treatment with insulin-like growth factor-I. These results indicate that growth hormone exerts its effects on lipoprotein metabolism independent of insulin-like growth factor-I. Furthermore, the results suggest that treatment with insulin-like growth factor-I may reduce lipoprotein(a) levels.
KW - growth hormone
KW - insulin-like growth factor-I
KW - lipoprotein
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UR - http://www.scopus.com/inward/citedby.url?scp=0029074250&partnerID=8YFLogxK
M3 - Article
C2 - 7600115
AN - SCOPUS:0029074250
VL - 15
SP - 847
EP - 849
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 7
ER -