Hormonal mediation of the analgesia produced by food deprivation

Robert J. Hamm, Janet S. Knisely, Ann Watson, Bruce G Lyeth, D. F B Bossut

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Research has demonstrated that a wide variety of environmental conditions are capable of producing analgesia. In the present experiment, the analgesia produced by 24 hr of food deprivation was examined following adrenalectomy, hypophysectomy, naltrexone (7 mg/kg), dexamethasone (0.4 mg/kg), or saline treatment. Results revealed that 24 hr of starvation elicited an analgesic response in the saline-treated and sham-operated groups. Naltrexone, dexamethasone, adrenalectomy, and hypophysectomy blocked the analgesia produced by food deprivation. The results demonstrate that 24 hr of food deprivation induced an opiate-mediated analgesic system that involves hormonal factors.

Original languageEnglish (US)
Pages (from-to)879-882
Number of pages4
JournalPhysiology and Behavior
Issue number6
StatePublished - 1985
Externally publishedYes


  • Adrenalectomy
  • Analgesia
  • Dexamethasone
  • Food deprivation
  • Hypophysectomy
  • Naltrexone
  • Stress-induced analgesia

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience


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