Hormonal effects on the brain

C. S. Woolley; Philip A Schwartzkroin

Hormonal effects on the brain

Research output: Contribution to journal › Article › peer-review

Abstract

Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.

Original language	English (US)
Journal	Epilepsia
Volume	40
Issue number	1 SUPPL.
State	Published - 1999
Externally published	Yes

Keywords

Estradiol
Hippocampus
NMDA receptors
Progesterone
Seizures

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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abstract = "Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.",

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AB - Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.

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KW - Hippocampus

KW - NMDA receptors

KW - Progesterone

KW - Seizures

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