Abstract
Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.
| Original language | English (US) |
|---|---|
| Journal | Epilepsia |
| Volume | 40 |
| Issue number | 1 SUPPL. |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- Estradiol
- Hippocampus
- NMDA receptors
- Progesterone
- Seizures
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Hormonal effects on the brain. / Woolley, C. S.; Schwartzkroin, Philip A.
In: Epilepsia, Vol. 40, No. 1 SUPPL., 1999.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hormonal effects on the brain
AU - Woolley, C. S.
AU - Schwartzkroin, Philip A
PY - 1999
Y1 - 1999
N2 - Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.
AB - Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.
KW - Estradiol
KW - Hippocampus
KW - NMDA receptors
KW - Progesterone
KW - Seizures
UR - http://www.scopus.com/inward/record.url?scp=0032946824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032946824&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032946824
VL - 40
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 1 SUPPL.
ER -