Hormonal effects on the brain

Catherine S. Woolley, Philip A Schwartzkroin

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.

Original languageEnglish (US)
JournalEpilepsia
Volume39
Issue numberSUPPL. 8
StatePublished - 1998
Externally publishedYes

Fingerprint

Estrogens
Seizures
Steroids
Hormones
Menstruation
Brain
Menstrual Cycle
Epilepsy
Hippocampus
Animal Models
Neurons

Keywords

  • Estradiol progesterone
  • Hippocampus
  • Nmda receptors
  • Seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Hormonal effects on the brain. / Woolley, Catherine S.; Schwartzkroin, Philip A.

In: Epilepsia, Vol. 39, No. SUPPL. 8, 1998.

Research output: Contribution to journalArticle

Woolley, CS & Schwartzkroin, PA 1998, 'Hormonal effects on the brain', Epilepsia, vol. 39, no. SUPPL. 8.
Woolley, Catherine S. ; Schwartzkroin, Philip A. / Hormonal effects on the brain. In: Epilepsia. 1998 ; Vol. 39, No. SUPPL. 8.
@article{f91479625f6a4674a2b8fde292a6a06b,
title = "Hormonal effects on the brain",
abstract = "Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.",
keywords = "Estradiol progesterone, Hippocampus, Nmda receptors, Seizures",
author = "Woolley, {Catherine S.} and Schwartzkroin, {Philip A}",
year = "1998",
language = "English (US)",
volume = "39",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "SUPPL. 8",

}

TY - JOUR

T1 - Hormonal effects on the brain

AU - Woolley, Catherine S.

AU - Schwartzkroin, Philip A

PY - 1998

Y1 - 1998

N2 - Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.

AB - Changes in seizure frequency over the course of the menstrual cycle (i.e., catamenial epilepsy) have long been documented. Ovarian steroid hormones have a number of important short- and long-term effects on the brain that may contribute to this phenomenon. In particular, estrogen induces structural and functional changes in hippocampal neurons which may contribute significantly to increasing seizure susceptibility. This article reviews the mechanisms of action of steroid hormones on the basis of findings in animal models, with particular emphasis on the effects of estrogen on the hippocampus.

KW - Estradiol progesterone

KW - Hippocampus

KW - Nmda receptors

KW - Seizures

UR - http://www.scopus.com/inward/record.url?scp=0032253107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032253107&partnerID=8YFLogxK

M3 - Article

C2 - 9915614

AN - SCOPUS:0032253107

VL - 39

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - SUPPL. 8

ER -