Hooked on the D3 Receptor: CaMKII's New Addiction

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Abstract

The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavior to foster drug-seeking behavior.

Original languageEnglish (US)
Pages (from-to)335-336
Number of pages2
JournalNeuron
Volume61
Issue number3
DOIs
StatePublished - Feb 12 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

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