Homologous association of oppositely imprinted chromosomal domains

Janine M LaSalle, M. Lalande

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Human chromosome 15q11-q13 encompasses the Prader-Willi syndrome (PWS) and the Angelman syndrome (AS) loci, which are subject to parental imprinting, a process that marks the parental origin of certain chromosomal subregions. A temporal and spatial association between maternal and paternal chromosomes 15 was observed in human T lymphocytes by three-dimensional fluorescence in situ hybridization. This association occurred specifically at the imprinted 15q11-q13 regions only during the late S phase of the cell cycle. Cells from PWS and AS patients were deficient in association, which suggests that normal imprinting involves mutual recognition and preferential association of maternal and paternal chromosomes 15.

Original languageEnglish (US)
Pages (from-to)725-728
Number of pages4
JournalScience
Volume272
Issue number5262
StatePublished - May 3 1996
Externally publishedYes

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Angelman Syndrome
Prader-Willi Syndrome
Chromosomes, Human, Pair 15
Mothers
Genomic Imprinting
Human Chromosomes
Fluorescence In Situ Hybridization
S Phase
Cell Cycle
T-Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

Homologous association of oppositely imprinted chromosomal domains. / LaSalle, Janine M; Lalande, M.

In: Science, Vol. 272, No. 5262, 03.05.1996, p. 725-728.

Research output: Contribution to journalArticle

LaSalle, JM & Lalande, M 1996, 'Homologous association of oppositely imprinted chromosomal domains', Science, vol. 272, no. 5262, pp. 725-728.
LaSalle, Janine M ; Lalande, M. / Homologous association of oppositely imprinted chromosomal domains. In: Science. 1996 ; Vol. 272, No. 5262. pp. 725-728.
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