Homocysteine, folate deficiency, and Parkinson's disease

Joshua W. Miller

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Folate deficiency sensitizes mice to dopaminergic neurodegeneration and motor dysfunction caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Additional experiments indicate that this effect of folate deficiency may be mediated by homocysteine. These findings suggest that folate deficiency and hyperhomocysteinemia are risk factors for Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)410-413
Number of pages4
JournalNutrition Reviews
Volume60
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

Fingerprint

Deficiency Diseases
deficiency diseases
Parkinson disease
homocysteine
Homocysteine
Folic Acid
folic acid
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Hyperhomocysteinemia
neurotoxins
Neurotoxins
risk factors
mice

Keywords

  • Folate deficiency
  • Homocysteine
  • MPTP
  • Neurodegeneration
  • Parkinson's disease

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Homocysteine, folate deficiency, and Parkinson's disease. / Miller, Joshua W.

In: Nutrition Reviews, Vol. 60, No. 12, 01.12.2002, p. 410-413.

Research output: Contribution to journalArticle

Miller, Joshua W. / Homocysteine, folate deficiency, and Parkinson's disease. In: Nutrition Reviews. 2002 ; Vol. 60, No. 12. pp. 410-413.
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