Homocysteine and Alzheimer's disease

Joshua W. Miller

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


In a recent case-control study of 164 patients with clinically diagnosed Alzheimer's disease (AD), including 76 patients with the AD diagnosis confirmed postmortem, mean total serum homocysteine concentration was found to be significantly higher than that of a control group of elderly individuals with no evidence of cognitive impairment. Because homocysteine is considered an independent risk factor for vascular disease, this finding is consistent with the emerging hypothesis that vascular disease is a contributing factor in the pathogenesis of AD.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalNutrition Reviews
Issue number4
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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