Homeward bound: How do skin dendritic cells find their way into the lymph system

Samuel T Hwang

doi:10.1038/jid.2012.39

Homeward bound: How do skin dendritic cells find their way into the lymph system

Samuel T Hwang

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The success of the adaptive immune system relies upon the transport of antigens by dendritic cells (DCs) from skin via lymphatic vessels to lymph nodes where DCs present antigen to T cells. Little is known about the requirements for so-called "reverse transmigration" (RT). Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics.

Original language	English (US)
Pages (from-to)	1070-1073
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	132
Issue number	4
DOIs	https://doi.org/10.1038/jid.2012.39
State	Published - Apr 2012
Externally published	Yes

ASJC Scopus subject areas

Dermatology
Biochemistry
Cell Biology
Molecular Biology

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10.1038/jid.2012.39

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