Abstract
The success of the adaptive immune system relies upon the transport of antigens by dendritic cells (DCs) from skin via lymphatic vessels to lymph nodes where DCs present antigen to T cells. Little is known about the requirements for so-called "reverse transmigration" (RT). Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1070-1073 |
| Number of pages | 4 |
| Journal | Journal of Investigative Dermatology |
| Volume | 132 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Homeward bound : How do skin dendritic cells find their way into the lymph system. / Hwang, Samuel T.
In: Journal of Investigative Dermatology, Vol. 132, No. 4, 04.2012, p. 1070-1073.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Homeward bound
T2 - How do skin dendritic cells find their way into the lymph system
AU - Hwang, Samuel T
PY - 2012/4
Y1 - 2012/4
N2 - The success of the adaptive immune system relies upon the transport of antigens by dendritic cells (DCs) from skin via lymphatic vessels to lymph nodes where DCs present antigen to T cells. Little is known about the requirements for so-called "reverse transmigration" (RT). Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics.
AB - The success of the adaptive immune system relies upon the transport of antigens by dendritic cells (DCs) from skin via lymphatic vessels to lymph nodes where DCs present antigen to T cells. Little is known about the requirements for so-called "reverse transmigration" (RT). Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics.
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UR - http://www.scopus.com/inward/citedby.url?scp=84858171846&partnerID=8YFLogxK
U2 - 10.1038/jid.2012.39
DO - 10.1038/jid.2012.39
M3 - Review article
C2 - 22418941
AN - SCOPUS:84858171846
VL - 132
SP - 1070
EP - 1073
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 4
ER -