Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.

Alice F Tarantal; G. Otiang-a-Owiti; Andrew G Hendrickx

Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.

Alice F Tarantal, G. Otiang-a-Owiti, Andrew G Hendrickx

Cell Biology and Human Anatomy, and General

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

Original language	English (US)
Pages (from-to)	319-324
Number of pages	6
Journal	Journal of Medical Primatology
Volume	23
Issue number	6
State	Published - Aug 1994

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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title = "Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.",

abstract = "A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.",

author = "Tarantal, {Alice F} and G. Otiang-a-Owiti and Hendrickx, {Andrew G}",

year = "1994",

month = aug,

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AU - Otiang-a-Owiti, G.

AU - Hendrickx, Andrew G

PY - 1994/8

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N2 - A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

AB - A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

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