Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.

Alice F Tarantal, G. Otiang-a-Owiti, Andrew G Hendrickx

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalJournal of Medical Primatology
Volume23
Issue number6
StatePublished - Aug 1994

Fingerprint

Holoprosencephaly
Macaca fascicularis
Macaca
fetus
Fetus
Incomplete Abortion
case studies
Mifepristone
abortion (animals)
embryo (animal)
Embryonic Structures
drugs
blood
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Holoprosencephaly in a long-tailed macaque (Macaca fascicularis) : a case report. / Tarantal, Alice F; Otiang-a-Owiti, G.; Hendrickx, Andrew G.

In: Journal of Medical Primatology, Vol. 23, No. 6, 08.1994, p. 319-324.

Research output: Contribution to journalArticle

Tarantal, Alice F ; Otiang-a-Owiti, G. ; Hendrickx, Andrew G. / Holoprosencephaly in a long-tailed macaque (Macaca fascicularis) : a case report. In: Journal of Medical Primatology. 1994 ; Vol. 23, No. 6. pp. 319-324.
@article{ce585bf062f245788e3aa15d34e89dce,
title = "Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.",
abstract = "A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.",
author = "Tarantal, {Alice F} and G. Otiang-a-Owiti and Hendrickx, {Andrew G}",
year = "1994",
month = "8",
language = "English (US)",
volume = "23",
pages = "319--324",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "6",

}

TY - JOUR

T1 - Holoprosencephaly in a long-tailed macaque (Macaca fascicularis)

T2 - a case report.

AU - Tarantal, Alice F

AU - Otiang-a-Owiti, G.

AU - Hendrickx, Andrew G

PY - 1994/8

Y1 - 1994/8

N2 - A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

AB - A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

UR - http://www.scopus.com/inward/record.url?scp=0028490907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028490907&partnerID=8YFLogxK

M3 - Article

C2 - 7897638

AN - SCOPUS:0028490907

VL - 23

SP - 319

EP - 324

JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

SN - 0047-2565

IS - 6

ER -