Abstract
A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 319-324 |
| Number of pages | 6 |
| Journal | Journal of Medical Primatology |
| Volume | 23 |
| Issue number | 6 |
| State | Published - Aug 1994 |
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ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Holoprosencephaly in a long-tailed macaque (Macaca fascicularis) : a case report. / Tarantal, Alice F; Otiang-a-Owiti, G.; Hendrickx, Andrew G.
In: Journal of Medical Primatology, Vol. 23, No. 6, 08.1994, p. 319-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Holoprosencephaly in a long-tailed macaque (Macaca fascicularis)
T2 - a case report.
AU - Tarantal, Alice F
AU - Otiang-a-Owiti, G.
AU - Hendrickx, Andrew G
PY - 1994/8
Y1 - 1994/8
N2 - A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.
AB - A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.
UR - http://www.scopus.com/inward/record.url?scp=0028490907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028490907&partnerID=8YFLogxK
M3 - Article
C2 - 7897638
AN - SCOPUS:0028490907
VL - 23
SP - 319
EP - 324
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 6
ER -