Holoprosencephaly in a long-tailed macaque (Macaca fascicularis): a case report.

Alice F Tarantal, G. Otiang-a-Owiti, Andrew G Hendrickx

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A long-tailed macaque fetus with ethmocephaly, alobar holoprosencephaly, and arhinia is reported. This fetus was exposed to an antiprogestational agent, RU 486 (2.5 mg/kg intramuscular, once daily), during gestational days 15-18. Three hypotheses are proposed to explain these malformations: (1) they are a direct result of drug exposure, (2) they are a secondary effect of treatment and the result of decreased blood supply to the developing embryo due to an incomplete abortion, and (3) they represent a spontaneous occurrence.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalJournal of Medical Primatology
Issue number6
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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