HIV transmissions from a window-period platelet donation

Patricia M. Kopko, Leonor P Fernando, Erica N. Bonney, Jed L. Freeman, Paul V. Holland

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Recently, blood centers began investigational testing for HIV RNA by pooled nucleic acid testing (NAT). A 35-year-old frequent platelet donor tested HIV p24 antigen positive, antibody negative before implementation of NAT. He made 2 platelet donations (day -4 and -11) immediately before testing positive for HIV. The donor's HIV seroconversion was monitored, and stored samples were tested retrospectively for HIV RNA. Platelet recipients were tested for HIV infection. The day -4 sample tested positive for HIV RNA by pooled and individual sample NAT. The day -11 sample tested negative for HIV RNA by both NAT tests. The 2 recipients of the day -4 platelets tested HIV RNA and p24 antigen positive. The recipient of the day -11 platelets could not be tested because he had died. HIV NAT would have prevented transmission of HIV had it been available at the time of this donor's HIV seroconversion.

Original languageEnglish (US)
Pages (from-to)562-566
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume116
Issue number4
DOIs
StatePublished - Oct 2001
Externally publishedYes

Fingerprint

Blood Platelets
HIV
Nucleic Acids
RNA
HIV Core Protein p24
HIV Seropositivity
HIV Infections
Antibodies

Keywords

  • AIDS
  • HIV
  • HIV transmission
  • Nucleic acid testing
  • Platelets
  • Polymerase chain reaction
  • Transfusion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

HIV transmissions from a window-period platelet donation. / Kopko, Patricia M.; Fernando, Leonor P; Bonney, Erica N.; Freeman, Jed L.; Holland, Paul V.

In: American Journal of Clinical Pathology, Vol. 116, No. 4, 10.2001, p. 562-566.

Research output: Contribution to journalArticle

Kopko, Patricia M. ; Fernando, Leonor P ; Bonney, Erica N. ; Freeman, Jed L. ; Holland, Paul V. / HIV transmissions from a window-period platelet donation. In: American Journal of Clinical Pathology. 2001 ; Vol. 116, No. 4. pp. 562-566.
@article{95104190d35c456bbeb3f1f00a9f66b5,
title = "HIV transmissions from a window-period platelet donation",
abstract = "Recently, blood centers began investigational testing for HIV RNA by pooled nucleic acid testing (NAT). A 35-year-old frequent platelet donor tested HIV p24 antigen positive, antibody negative before implementation of NAT. He made 2 platelet donations (day -4 and -11) immediately before testing positive for HIV. The donor's HIV seroconversion was monitored, and stored samples were tested retrospectively for HIV RNA. Platelet recipients were tested for HIV infection. The day -4 sample tested positive for HIV RNA by pooled and individual sample NAT. The day -11 sample tested negative for HIV RNA by both NAT tests. The 2 recipients of the day -4 platelets tested HIV RNA and p24 antigen positive. The recipient of the day -11 platelets could not be tested because he had died. HIV NAT would have prevented transmission of HIV had it been available at the time of this donor's HIV seroconversion.",
keywords = "AIDS, HIV, HIV transmission, Nucleic acid testing, Platelets, Polymerase chain reaction, Transfusion",
author = "Kopko, {Patricia M.} and Fernando, {Leonor P} and Bonney, {Erica N.} and Freeman, {Jed L.} and Holland, {Paul V.}",
year = "2001",
month = "10",
doi = "10.1309/GBLA-NL8D-3277-XUP1",
language = "English (US)",
volume = "116",
pages = "562--566",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "4",

}

TY - JOUR

T1 - HIV transmissions from a window-period platelet donation

AU - Kopko, Patricia M.

AU - Fernando, Leonor P

AU - Bonney, Erica N.

AU - Freeman, Jed L.

AU - Holland, Paul V.

PY - 2001/10

Y1 - 2001/10

N2 - Recently, blood centers began investigational testing for HIV RNA by pooled nucleic acid testing (NAT). A 35-year-old frequent platelet donor tested HIV p24 antigen positive, antibody negative before implementation of NAT. He made 2 platelet donations (day -4 and -11) immediately before testing positive for HIV. The donor's HIV seroconversion was monitored, and stored samples were tested retrospectively for HIV RNA. Platelet recipients were tested for HIV infection. The day -4 sample tested positive for HIV RNA by pooled and individual sample NAT. The day -11 sample tested negative for HIV RNA by both NAT tests. The 2 recipients of the day -4 platelets tested HIV RNA and p24 antigen positive. The recipient of the day -11 platelets could not be tested because he had died. HIV NAT would have prevented transmission of HIV had it been available at the time of this donor's HIV seroconversion.

AB - Recently, blood centers began investigational testing for HIV RNA by pooled nucleic acid testing (NAT). A 35-year-old frequent platelet donor tested HIV p24 antigen positive, antibody negative before implementation of NAT. He made 2 platelet donations (day -4 and -11) immediately before testing positive for HIV. The donor's HIV seroconversion was monitored, and stored samples were tested retrospectively for HIV RNA. Platelet recipients were tested for HIV infection. The day -4 sample tested positive for HIV RNA by pooled and individual sample NAT. The day -11 sample tested negative for HIV RNA by both NAT tests. The 2 recipients of the day -4 platelets tested HIV RNA and p24 antigen positive. The recipient of the day -11 platelets could not be tested because he had died. HIV NAT would have prevented transmission of HIV had it been available at the time of this donor's HIV seroconversion.

KW - AIDS

KW - HIV

KW - HIV transmission

KW - Nucleic acid testing

KW - Platelets

KW - Polymerase chain reaction

KW - Transfusion

UR - http://www.scopus.com/inward/record.url?scp=0035736515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035736515&partnerID=8YFLogxK

U2 - 10.1309/GBLA-NL8D-3277-XUP1

DO - 10.1309/GBLA-NL8D-3277-XUP1

M3 - Article

C2 - 11601141

AN - SCOPUS:0035736515

VL - 116

SP - 562

EP - 566

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 4

ER -