HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients With HIV

Emily C. Williams, Kathleen A. McGinnis, Janet P. Tate, Theresa E. Matson, Anna D. Rubinsky, Jennifer F. Bobb, Gwen T. Lapham, E. Jennifer Edelman, Sheryl L Catz, Derek D. Satre, Kendall J. Bryant, Brandon D.L. Marshall, Kevin L. Kraemer, Kara M. Bensley, Julie E. Richards, Melissa Skanderson, Amy C. Justice, David A. Fiellin, Katharine A. Bradley

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Alcohol use influences HIV disease severity through multiple mechanisms. Whether HIV disease severity is sensitive to changes in alcohol use among people with HIV (PWH) is understudied. SETTING: National Veterans Health Administration. METHODS: Pairs of AUDIT-C screens within 9-15 months (February 1, 2008-September 30, 2014) were identified among PWH from the Veterans Aging Cohort Study (VACS). Initial and follow-up VACS Index 2.0 pairs obtained 0-270 days after initial and follow-up AUDIT-Cs, respectively, determined change in VACS Index 2.0, a composite HIV severity measure. Change in VACS Index 2.0 was regressed on AUDIT-C change scores (-12 to +12) adjusted for demographics, initial VACS Index 2.0, and days between VACS Index measures. RESULTS: Among 23,297 PWH (76,202 observations), most had no (51%) or low-level (38%) alcohol use initially. Most (54%) had no subsequent change; 21% increased and 24% decreased drinking. Initial VACS Index 2.0 scores ranged from 0 to 134, change scores ranged from -65 to +73, with average improvement of 0.76 points (SD 9.48). AUDIT-C change was associated with VACS Index 2.0 change (P < 0.001). Among those with stable alcohol use (AUDIT-C change ≤ │1│ point), VACS Index 2.0 improvements ranged 0.36-0.60 points. For those with maximum AUDIT-C increase (change from 0 to 12), VACS Index 2.0 worsened 3.74 points (95% CI: -4.71 to -2.78); for those with maximum AUDIT-C decrease (change from 12 to 0), VACS Index 2.0 changed minimally [-0.60 (95% CI: -1.43 to 0.23)]. CONCLUSIONS: In this national sample, improvement in HIV severity was generally greatest among those with stable alcohol use (primarily those with no use).

Original languageEnglish (US)
Pages (from-to)448-455
Number of pages8
JournalJournal of acquired immune deficiency syndromes (1999)
Volume81
Issue number4
DOIs
StatePublished - Aug 1 2019

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Veterans
Cohort Studies
Alcohols
HIV
Veterans Health
United States Department of Veterans Affairs
Drinking
Demography

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Williams, E. C., McGinnis, K. A., Tate, J. P., Matson, T. E., Rubinsky, A. D., Bobb, J. F., ... Bradley, K. A. (2019). HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients With HIV. Journal of acquired immune deficiency syndromes (1999), 81(4), 448-455. https://doi.org/10.1097/QAI.0000000000002049

HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use : A National Study of VA Patients With HIV. / Williams, Emily C.; McGinnis, Kathleen A.; Tate, Janet P.; Matson, Theresa E.; Rubinsky, Anna D.; Bobb, Jennifer F.; Lapham, Gwen T.; Edelman, E. Jennifer; Catz, Sheryl L; Satre, Derek D.; Bryant, Kendall J.; Marshall, Brandon D.L.; Kraemer, Kevin L.; Bensley, Kara M.; Richards, Julie E.; Skanderson, Melissa; Justice, Amy C.; Fiellin, David A.; Bradley, Katharine A.

In: Journal of acquired immune deficiency syndromes (1999), Vol. 81, No. 4, 01.08.2019, p. 448-455.

Research output: Contribution to journalArticle

Williams, EC, McGinnis, KA, Tate, JP, Matson, TE, Rubinsky, AD, Bobb, JF, Lapham, GT, Edelman, EJ, Catz, SL, Satre, DD, Bryant, KJ, Marshall, BDL, Kraemer, KL, Bensley, KM, Richards, JE, Skanderson, M, Justice, AC, Fiellin, DA & Bradley, KA 2019, 'HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients With HIV', Journal of acquired immune deficiency syndromes (1999), vol. 81, no. 4, pp. 448-455. https://doi.org/10.1097/QAI.0000000000002049
Williams, Emily C. ; McGinnis, Kathleen A. ; Tate, Janet P. ; Matson, Theresa E. ; Rubinsky, Anna D. ; Bobb, Jennifer F. ; Lapham, Gwen T. ; Edelman, E. Jennifer ; Catz, Sheryl L ; Satre, Derek D. ; Bryant, Kendall J. ; Marshall, Brandon D.L. ; Kraemer, Kevin L. ; Bensley, Kara M. ; Richards, Julie E. ; Skanderson, Melissa ; Justice, Amy C. ; Fiellin, David A. ; Bradley, Katharine A. / HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use : A National Study of VA Patients With HIV. In: Journal of acquired immune deficiency syndromes (1999). 2019 ; Vol. 81, No. 4. pp. 448-455.
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abstract = "BACKGROUND: Alcohol use influences HIV disease severity through multiple mechanisms. Whether HIV disease severity is sensitive to changes in alcohol use among people with HIV (PWH) is understudied. SETTING: National Veterans Health Administration. METHODS: Pairs of AUDIT-C screens within 9-15 months (February 1, 2008-September 30, 2014) were identified among PWH from the Veterans Aging Cohort Study (VACS). Initial and follow-up VACS Index 2.0 pairs obtained 0-270 days after initial and follow-up AUDIT-Cs, respectively, determined change in VACS Index 2.0, a composite HIV severity measure. Change in VACS Index 2.0 was regressed on AUDIT-C change scores (-12 to +12) adjusted for demographics, initial VACS Index 2.0, and days between VACS Index measures. RESULTS: Among 23,297 PWH (76,202 observations), most had no (51{\%}) or low-level (38{\%}) alcohol use initially. Most (54{\%}) had no subsequent change; 21{\%} increased and 24{\%} decreased drinking. Initial VACS Index 2.0 scores ranged from 0 to 134, change scores ranged from -65 to +73, with average improvement of 0.76 points (SD 9.48). AUDIT-C change was associated with VACS Index 2.0 change (P < 0.001). Among those with stable alcohol use (AUDIT-C change ≤ │1│ point), VACS Index 2.0 improvements ranged 0.36-0.60 points. For those with maximum AUDIT-C increase (change from 0 to 12), VACS Index 2.0 worsened 3.74 points (95{\%} CI: -4.71 to -2.78); for those with maximum AUDIT-C decrease (change from 12 to 0), VACS Index 2.0 changed minimally [-0.60 (95{\%} CI: -1.43 to 0.23)]. CONCLUSIONS: In this national sample, improvement in HIV severity was generally greatest among those with stable alcohol use (primarily those with no use).",
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T1 - HIV Disease Severity Is Sensitive to Temporal Changes in Alcohol Use

T2 - A National Study of VA Patients With HIV

AU - Williams, Emily C.

AU - McGinnis, Kathleen A.

AU - Tate, Janet P.

AU - Matson, Theresa E.

AU - Rubinsky, Anna D.

AU - Bobb, Jennifer F.

AU - Lapham, Gwen T.

AU - Edelman, E. Jennifer

AU - Catz, Sheryl L

AU - Satre, Derek D.

AU - Bryant, Kendall J.

AU - Marshall, Brandon D.L.

AU - Kraemer, Kevin L.

AU - Bensley, Kara M.

AU - Richards, Julie E.

AU - Skanderson, Melissa

AU - Justice, Amy C.

AU - Fiellin, David A.

AU - Bradley, Katharine A.

PY - 2019/8/1

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N2 - BACKGROUND: Alcohol use influences HIV disease severity through multiple mechanisms. Whether HIV disease severity is sensitive to changes in alcohol use among people with HIV (PWH) is understudied. SETTING: National Veterans Health Administration. METHODS: Pairs of AUDIT-C screens within 9-15 months (February 1, 2008-September 30, 2014) were identified among PWH from the Veterans Aging Cohort Study (VACS). Initial and follow-up VACS Index 2.0 pairs obtained 0-270 days after initial and follow-up AUDIT-Cs, respectively, determined change in VACS Index 2.0, a composite HIV severity measure. Change in VACS Index 2.0 was regressed on AUDIT-C change scores (-12 to +12) adjusted for demographics, initial VACS Index 2.0, and days between VACS Index measures. RESULTS: Among 23,297 PWH (76,202 observations), most had no (51%) or low-level (38%) alcohol use initially. Most (54%) had no subsequent change; 21% increased and 24% decreased drinking. Initial VACS Index 2.0 scores ranged from 0 to 134, change scores ranged from -65 to +73, with average improvement of 0.76 points (SD 9.48). AUDIT-C change was associated with VACS Index 2.0 change (P < 0.001). Among those with stable alcohol use (AUDIT-C change ≤ │1│ point), VACS Index 2.0 improvements ranged 0.36-0.60 points. For those with maximum AUDIT-C increase (change from 0 to 12), VACS Index 2.0 worsened 3.74 points (95% CI: -4.71 to -2.78); for those with maximum AUDIT-C decrease (change from 12 to 0), VACS Index 2.0 changed minimally [-0.60 (95% CI: -1.43 to 0.23)]. CONCLUSIONS: In this national sample, improvement in HIV severity was generally greatest among those with stable alcohol use (primarily those with no use).

AB - BACKGROUND: Alcohol use influences HIV disease severity through multiple mechanisms. Whether HIV disease severity is sensitive to changes in alcohol use among people with HIV (PWH) is understudied. SETTING: National Veterans Health Administration. METHODS: Pairs of AUDIT-C screens within 9-15 months (February 1, 2008-September 30, 2014) were identified among PWH from the Veterans Aging Cohort Study (VACS). Initial and follow-up VACS Index 2.0 pairs obtained 0-270 days after initial and follow-up AUDIT-Cs, respectively, determined change in VACS Index 2.0, a composite HIV severity measure. Change in VACS Index 2.0 was regressed on AUDIT-C change scores (-12 to +12) adjusted for demographics, initial VACS Index 2.0, and days between VACS Index measures. RESULTS: Among 23,297 PWH (76,202 observations), most had no (51%) or low-level (38%) alcohol use initially. Most (54%) had no subsequent change; 21% increased and 24% decreased drinking. Initial VACS Index 2.0 scores ranged from 0 to 134, change scores ranged from -65 to +73, with average improvement of 0.76 points (SD 9.48). AUDIT-C change was associated with VACS Index 2.0 change (P < 0.001). Among those with stable alcohol use (AUDIT-C change ≤ │1│ point), VACS Index 2.0 improvements ranged 0.36-0.60 points. For those with maximum AUDIT-C increase (change from 0 to 12), VACS Index 2.0 worsened 3.74 points (95% CI: -4.71 to -2.78); for those with maximum AUDIT-C decrease (change from 12 to 0), VACS Index 2.0 changed minimally [-0.60 (95% CI: -1.43 to 0.23)]. CONCLUSIONS: In this national sample, improvement in HIV severity was generally greatest among those with stable alcohol use (primarily those with no use).

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