HIV disease activity as a modulator of lipoprotein(a) and allele-specific apolipoprotein(a) levels

Enkhmaa Byambaa, Anuurad Erdembileg, Wei Zhang, Adnan Abbuthalha, Xiao Dong Li, William Dotterweich, Richard B Pollard, David Asmuth, Lars Berglund

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective-: Mechanisms underlying the cardiovascular risk of lipoprotein(a) are poorly understood. We investigated the relationship of apolipoprotein(a) (apo(a)) size, lipoprotein(a), and allele-specific apo(a) levels with HIV disease activity parameters in a biethnic population. METHODS AND RESULTS-: Lipoprotein(a) and allele-specific apo(a) levels were determined in 139 white and 168 black HIV-positive patients. Plasma HIV RNA viral load and CD4+ T-cell count were used as surrogates for disease activity. Lipoprotein(a) and allele-specific apo(a) levels were higher in blacks than whites (for both P<0.001). Apo(a) allele size distribution was similar between the 2 ethnic groups, with a median apo(a) size of 28 kringle 4 repeats. Allele-specific apo(a) levels were positively associated with CD4+ T-cell count (P=0.027) and negatively with plasma HIV RNA viral load (P<0.001). Further, allele-specific apo(a) levels associated with smaller (<28 kringle 4) atherogenic apo(a) sizes were higher in subjects with CD4+ T-cell counts of ≥350 (P=0.002). CONCLUSION-: Allele-specific apo(a) levels were higher in subjects with high CD4+ T-cell count or low plasma HIV RNA viral load. The findings suggest that HIV disease activity reduced allele-specific apo(a) levels. Higher allele-specific apo(a) levels associated with atherogenic small apo(a) sizes might contribute to increased cardiovascular risk in HIV-positive subjects with improved disease status.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume33
Issue number2
DOIs
StatePublished - Feb 2013

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Apoprotein(a)
Lipoprotein(a)
Alleles
HIV
CD4 Lymphocyte Count
Viral Load
Kringles
T-Lymphocytes
RNA
Ethnic Groups

Keywords

  • apo(a) size
  • cardiovascular risk
  • CD4+ T-cells
  • HIV
  • Lp(a)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

HIV disease activity as a modulator of lipoprotein(a) and allele-specific apolipoprotein(a) levels. / Byambaa, Enkhmaa; Erdembileg, Anuurad; Zhang, Wei; Abbuthalha, Adnan; Li, Xiao Dong; Dotterweich, William; Pollard, Richard B; Asmuth, David; Berglund, Lars.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33, No. 2, 02.2013, p. 387-392.

Research output: Contribution to journalArticle

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abstract = "Objective-: Mechanisms underlying the cardiovascular risk of lipoprotein(a) are poorly understood. We investigated the relationship of apolipoprotein(a) (apo(a)) size, lipoprotein(a), and allele-specific apo(a) levels with HIV disease activity parameters in a biethnic population. METHODS AND RESULTS-: Lipoprotein(a) and allele-specific apo(a) levels were determined in 139 white and 168 black HIV-positive patients. Plasma HIV RNA viral load and CD4+ T-cell count were used as surrogates for disease activity. Lipoprotein(a) and allele-specific apo(a) levels were higher in blacks than whites (for both P<0.001). Apo(a) allele size distribution was similar between the 2 ethnic groups, with a median apo(a) size of 28 kringle 4 repeats. Allele-specific apo(a) levels were positively associated with CD4+ T-cell count (P=0.027) and negatively with plasma HIV RNA viral load (P<0.001). Further, allele-specific apo(a) levels associated with smaller (<28 kringle 4) atherogenic apo(a) sizes were higher in subjects with CD4+ T-cell counts of ≥350 (P=0.002). CONCLUSION-: Allele-specific apo(a) levels were higher in subjects with high CD4+ T-cell count or low plasma HIV RNA viral load. The findings suggest that HIV disease activity reduced allele-specific apo(a) levels. Higher allele-specific apo(a) levels associated with atherogenic small apo(a) sizes might contribute to increased cardiovascular risk in HIV-positive subjects with improved disease status.",
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