Abstract
We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus result in the development of immune responses that control viral replication and lead to prolonged survival.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2085-2087 |
| Number of pages | 3 |
| Journal | AIDS |
| Volume | 16 |
| Issue number | 15 |
| DOIs | |
| State | Published - Oct 18 2002 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Cite this
Chakraborty, R., Gillespie, G. M. A., Reinis, M., Rostron, T., Dong, T., Philpott, S., Burger, H., Weiser, B., Peto, T., & Rowland-Jones, S. L. (2002). HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate. AIDS, 16(15), 2085-2087. https://doi.org/10.1097/00002030-200210180-00017