HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate

Rana Chakraborty, Geraldine M A Gillespie, Milan Reinis, Tim Rostron, Tao Dong, Sean Philpott, Harold Burger, Barbara Weiser, Tim Peto, Sarah L. Rowland-Jones

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus result in the development of immune responses that control viral replication and lead to prolonged survival.

Original languageEnglish (US)
Pages (from-to)2085-2087
Number of pages3
JournalAIDS
Volume16
Issue number15
DOIs
StatePublished - Oct 18 2002
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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