TY - JOUR
T1 - HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate
AU - Chakraborty, Rana
AU - Gillespie, Geraldine M A
AU - Reinis, Milan
AU - Rostron, Tim
AU - Dong, Tao
AU - Philpott, Sean
AU - Burger, Harold
AU - Weiser, Barbara
AU - Peto, Tim
AU - Rowland-Jones, Sarah L.
PY - 2002/10/18
Y1 - 2002/10/18
N2 - We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus result in the development of immune responses that control viral replication and lead to prolonged survival.
AB - We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus result in the development of immune responses that control viral replication and lead to prolonged survival.
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U2 - 10.1097/00002030-200210180-00017
DO - 10.1097/00002030-200210180-00017
M3 - Article
C2 - 12370511
AN - SCOPUS:0037131201
VL - 16
SP - 2085
EP - 2087
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 15
ER -