HIV-1 infected monozygotic twins: A tale of two outcomes

Loubna Rothenburg, Hiromi Imamichi, Steven Hirschfeld, Julia A. Metcalf, Susan Orsega, Marcos Pérez-Losada, David Posada, H. Clifford Lane, Keith A. Crandall

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background. Replicate experiments are often difficult to find in evolutionary biology, as this field is inherently an historical science. However, viruses, bacteria and phages provide opportunities to study evolution in both natural and experimental contexts, due to their accelerated rates of evolution and short generation times. Here we investigate HIV-1 evolution by using a natural model represented by monozygotic twins infected synchronically at birth with an HIV-1 population from a shared blood transfusion source. We explore the evolutionary processes and population dynamics that shape viral diversity of HIV in these monozygotic twins. Results. Despite the identical host genetic backdrop of monozygotic twins and the identical source and timing of the HIV-1 inoculation, the resulting HIV populations differed in genetic diversity, growth rate, recombination rate, and selection pressure between the two infected twins. Conclusions. Our study shows that the outcome of evolution is strikingly different between these two "replicates" of viral evolution. Given the identical starting points at infection, our results support the impact of random epigenetic selection in early infection dynamics. Our data also emphasize the need for a better understanding of the impact of host-virus interactions in viral evolution.

Original languageEnglish (US)
Article number62
JournalBMC Evolutionary Biology
Issue number1
StatePublished - Mar 14 2011
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics


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