History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator

Emre Aksay, Guy Major, Mark S Goldman, Robert Baker, H. Sebastian Seung, David W. Tank

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Persistent firing in response to a brief stimulus is a neural correlate of short-term memory in a variety of systems. In the oculomotor neural integrator, persistent firing that encodes eye position is maintained in response to transient saccadic eye-velocity commands. To a first approximation, firing rates in the integrator vary linearly with eye position. Thus, viewed across many cells, the pattern of persistent firing in the integrator may be constrained to a unique line of stable states. Here this idea was tested by examining the relationship between firing rates of simultaneously recorded neurons. Paired recordings were obtained in awake goldfish from neurons in hindbrain area I, an essential part of the horizontal eye-position integrator. During spontaneous eye movements consisting of sequential fixations at different horizontal positions, the pair relationship between the majority of cells on the same side of the integrator was not unique: for a given rate of one cell, the rate of the paired cell assumed different values that depended systematically on the preceding saccade history. This finding suggests that the set of persistent firing states that encode eye position is not constrained to a unique line, and that models with stable states restricted to a such a line need to be modified accordingly.

Original languageEnglish (US)
Pages (from-to)1173-1184
Number of pages12
JournalCerebral Cortex
Volume13
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

History
Neurons
Rhombencephalon
Goldfish
Saccades
Eye Movements
Short-Term Memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Aksay, E., Major, G., Goldman, M. S., Baker, R., Seung, H. S., & Tank, D. W. (2003). History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator. Cerebral Cortex, 13(11), 1173-1184. https://doi.org/10.1093/cercor/bhg099

History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator. / Aksay, Emre; Major, Guy; Goldman, Mark S; Baker, Robert; Seung, H. Sebastian; Tank, David W.

In: Cerebral Cortex, Vol. 13, No. 11, 11.2003, p. 1173-1184.

Research output: Contribution to journalArticle

Aksay, E, Major, G, Goldman, MS, Baker, R, Seung, HS & Tank, DW 2003, 'History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator', Cerebral Cortex, vol. 13, no. 11, pp. 1173-1184. https://doi.org/10.1093/cercor/bhg099
Aksay, Emre ; Major, Guy ; Goldman, Mark S ; Baker, Robert ; Seung, H. Sebastian ; Tank, David W. / History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator. In: Cerebral Cortex. 2003 ; Vol. 13, No. 11. pp. 1173-1184.
@article{c3f0ec18934d49b7835a4665667453d5,
title = "History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator",
abstract = "Persistent firing in response to a brief stimulus is a neural correlate of short-term memory in a variety of systems. In the oculomotor neural integrator, persistent firing that encodes eye position is maintained in response to transient saccadic eye-velocity commands. To a first approximation, firing rates in the integrator vary linearly with eye position. Thus, viewed across many cells, the pattern of persistent firing in the integrator may be constrained to a unique line of stable states. Here this idea was tested by examining the relationship between firing rates of simultaneously recorded neurons. Paired recordings were obtained in awake goldfish from neurons in hindbrain area I, an essential part of the horizontal eye-position integrator. During spontaneous eye movements consisting of sequential fixations at different horizontal positions, the pair relationship between the majority of cells on the same side of the integrator was not unique: for a given rate of one cell, the rate of the paired cell assumed different values that depended systematically on the preceding saccade history. This finding suggests that the set of persistent firing states that encode eye position is not constrained to a unique line, and that models with stable states restricted to a such a line need to be modified accordingly.",
author = "Emre Aksay and Guy Major and Goldman, {Mark S} and Robert Baker and Seung, {H. Sebastian} and Tank, {David W.}",
year = "2003",
month = "11",
doi = "10.1093/cercor/bhg099",
language = "English (US)",
volume = "13",
pages = "1173--1184",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - History Dependence of Rate Covariation between Neurons during Persistent Activity in an Oculomotor Integrator

AU - Aksay, Emre

AU - Major, Guy

AU - Goldman, Mark S

AU - Baker, Robert

AU - Seung, H. Sebastian

AU - Tank, David W.

PY - 2003/11

Y1 - 2003/11

N2 - Persistent firing in response to a brief stimulus is a neural correlate of short-term memory in a variety of systems. In the oculomotor neural integrator, persistent firing that encodes eye position is maintained in response to transient saccadic eye-velocity commands. To a first approximation, firing rates in the integrator vary linearly with eye position. Thus, viewed across many cells, the pattern of persistent firing in the integrator may be constrained to a unique line of stable states. Here this idea was tested by examining the relationship between firing rates of simultaneously recorded neurons. Paired recordings were obtained in awake goldfish from neurons in hindbrain area I, an essential part of the horizontal eye-position integrator. During spontaneous eye movements consisting of sequential fixations at different horizontal positions, the pair relationship between the majority of cells on the same side of the integrator was not unique: for a given rate of one cell, the rate of the paired cell assumed different values that depended systematically on the preceding saccade history. This finding suggests that the set of persistent firing states that encode eye position is not constrained to a unique line, and that models with stable states restricted to a such a line need to be modified accordingly.

AB - Persistent firing in response to a brief stimulus is a neural correlate of short-term memory in a variety of systems. In the oculomotor neural integrator, persistent firing that encodes eye position is maintained in response to transient saccadic eye-velocity commands. To a first approximation, firing rates in the integrator vary linearly with eye position. Thus, viewed across many cells, the pattern of persistent firing in the integrator may be constrained to a unique line of stable states. Here this idea was tested by examining the relationship between firing rates of simultaneously recorded neurons. Paired recordings were obtained in awake goldfish from neurons in hindbrain area I, an essential part of the horizontal eye-position integrator. During spontaneous eye movements consisting of sequential fixations at different horizontal positions, the pair relationship between the majority of cells on the same side of the integrator was not unique: for a given rate of one cell, the rate of the paired cell assumed different values that depended systematically on the preceding saccade history. This finding suggests that the set of persistent firing states that encode eye position is not constrained to a unique line, and that models with stable states restricted to a such a line need to be modified accordingly.

UR - http://www.scopus.com/inward/record.url?scp=0142188645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142188645&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhg099

DO - 10.1093/cercor/bhg099

M3 - Article

C2 - 14576209

AN - SCOPUS:0142188645

VL - 13

SP - 1173

EP - 1184

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 11

ER -