Historical review of the fluid-percussion TBI model

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is a major health concern worldwide. Laboratory studies utilizing animal models of TBI are essential for addressing pathological mechanisms of brain injury and development of innovative treatments. Over the past 75 years, pioneering head injury researchers have devised and tested a number of fluid percussive methods to reproduce the concussive clinical syndrome in animals. The fluid-percussion brain injury technique has evolved from early investigations that applied a generalized loading of the brain to more recent computer-controlled systems. Of the many preclinical TBI models, the fluid-percussion technique is one of the most extensively characterized and widely used models. Some of the most important advances involved the development of the Stalhammer device to produce concussion in cats and the later characterization of this device for application in rodents. The goal of this historical review is to provide readers with an appreciation for the time and effort expended by the pioneering researchers who have led to today's state of the art fluid-percussion animal models of TBI.

Original languageEnglish (US)
Article number217
JournalFrontiers in Neurology
Volume7
Issue numberDEC
DOIs
StatePublished - Dec 2 2016

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Percussion
Brain Injuries
Animal Models
Research Personnel
Equipment and Supplies
Computer Systems
Craniocerebral Trauma
Rodentia
Cats
Traumatic Brain Injury
Brain

Keywords

  • Brain trauma
  • Concussion
  • Experimental brain injury
  • Fluid percussion
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Historical review of the fluid-percussion TBI model. / Lyeth, Bruce G.

In: Frontiers in Neurology, Vol. 7, No. DEC, 217, 02.12.2016.

Research output: Contribution to journalReview article

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